Serum Vitamin E Deficiency among HIV-Infected Individuals Undergoing Antiretroviral Therapy at Ho Teaching Hospital, Ghana

Introduction. It has been suggested that serum vitamin E concentrations in CF patients may not properly reflect the body resources of vitamin E. Therefore, we aimed to assess vitamin E status in CF adults relating it to reference values for healthy subjects, also taking into account the α‑tocopherol:cholesterol ratio. Material and Methods. The study group was composed of 33 CF patients − 18 (54.5%) females and 15 (45.5%) males − aged from 18 to 47 years. In all CF patients nutritional status and clinical expression of disease − lung function; Pseudomonas aeruginosa colonization; diabetes; cirrhosis; exocrine pancreatic function and vitamin E supplementation were analyzed. Vitamin E (α‑tocopherol) concentration was assessed by high‑performance liquid chromatography (HPLC).Resuls. CF adults have lower vitamin E concentrations (median: 830 µg/dl vs. 1132 µg/dl, p = 0.00174) and higher vitamin E: cholesterol ratio (median: 7.2 mg/g vs. 6.7 mg/g, p < 0.00001) than healthy subjects. The underlying factor that determines this phenomenon is related to low cholesterol levels observed in CF patients. The percentage of low vitamin E concentrations defined in comparison to healthy Polish peers is considerably higher than low vitamin E:cholesterol ratios (39.4% vs. 21.2%, p = 0.0011). Conclusions. The evaluation of α‑tocopherol concentration instead of α‑tocopherol:cholesterol ratio in CF adults results in the overestimation of vitamin E deficiency. Moreover, there is also potentially a large percentage of individuals with excessive vitamin E body resources. However, this aspect demands further studies.

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The Association Between Vitamin E Deficiency and Critically Ill Children With Sepsis and Septic Shock

Frontiers in Nutrition ◽

10.3389/fnut.2021.648442 ◽

2021 ◽

Vol 8 ◽

Author(s):

Hongxing Dang ◽

Jing Li ◽

Chengjun Liu ◽

Feng Xu

Keyword(s):

Septic Shock ◽

Vitamin E ◽

Critically Ill ◽

Serum Vitamin ◽

Independent Effect ◽

Critically Ill Children ◽

Vitamin E Deficiency ◽

Suspected Infection ◽

Sepsis And Septic Shock ◽

Vitamin E Status

Background: Literature is scarce on the assessment of vitamin E status in septic children. We aim to investigate the prevalence of vitamin E deficiency in critically ill children with sepsis and septic shock and its association with clinical features and outcomes.Methods: We compared serum vitamin E status between the confirmed or suspected infection and no infection groups, the sepsis shock and no sepsis shock groups upon pediatric intensive care unit admission. Clinical characteristics were compared in subgroup patients with and without vitamin E deficiency. The association between vitamin E deficiency and septic shock were evaluated using univariate and multivariable methods.Results: 182 critically ill children with confirmed or suspected infection and 114 without infection were enrolled. The incidence of vitamin E deficiency was 30.2% in the infection group and 61.9% in the septic shock subgroup (P < 0.001). Thirty-days mortality in critically ill children with vitamin E deficiency was significantly higher than that without vitamin E deficiency (27.3 vs. 14.2%, P < 0.05). Vitamin E levels were inversely associated with higher pediatric risk of mortality (r = − 0.238, P = 0.001) and cardiovascular sequential organ failure assessment (r = −0.249, p < 0.001) scores in critically ill children with infection. In multivariable logistic regression, vitamin E deficiency showed an independent effect on septic shock (adjusted OR: 6.749, 95%CI: 2.449–18.60, P < 0.001).Conclusion: Vitamin E deficiency is highly prevalent in critically ill children with sepsis and contributed to the septic shock.

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Clinical and Genetic Study of Ataxia With Vitamin E Deficiency

10.21203/rs.3.rs-175944/v1 ◽

2021 ◽

Author(s):

Linwei Zhang ◽

Xiangfei Zhang ◽

Pu Lv ◽

Dantao Peng

Keyword(s):

Vitamin E ◽

Cerebellar Ataxia ◽

Protein Function ◽

Novel Mutation ◽

Brain Mri ◽

Serum Vitamin ◽

Gene Mutations ◽

Chinese Family ◽

Vitamin E Deficiency ◽

Progressive Cerebellar Ataxia

Abstract Background: Ataxia with Vitamin E deficiency (AVED) is a type of autosomal recessive cerebellar ataxia. The main clinical manifestation involves progressive cerebellar ataxia and movement disorders, α-tocopherol transfer protein(TTPA) gene mutations are responsible for this disease. Methods: A female patient from a consanguineous Chinese family underwent detailed physical and auxiliary examination. After exclusion of acquired causes of ataxia, Friedreich’s Ataxia, and common types of spinocerebellar ataxia, the patient was subjected to whole exome sequencing (WES) followed by confirmation of sequence variants using Sanger sequencing. Her asymptomatic parents and younger sister were genotyped for the variant. Results: This patient showed progressive cerebellar ataxia, dysarthria and dystonic tremor, her serum vitamin E concentration was remarkably decreased, brain MRI revealed no obvious cerebellum atrophy. Homozygous variant (c.473T>C, p.F158S) of TPPA gene were identified through WES. Bioinformatic analysis predicted F185S would be harmful to the protein function. After supplementation of vitamin E 400mg three times per day for two years, the patient’s symptom remained stabilization.Conclusions We identified an AVED patient caused by novel mutation in TTPA gene. Our findings widen the spectrum of TTPA gene mutations.

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The status of serum vitamin A/E and its effect on Recurrent Respiratory Tract Infections in children aged 2 to 17 years in Beijing, China, based on cross-sectional study

10.21203/rs.2.22863/v1 ◽

2020 ◽

Author(s):

Xiaoyan Wang ◽

Chunhua Jin ◽

Jiaxin Wang ◽

Jianhong Wang ◽

Lili Zhang ◽

...

Keyword(s):

Vitamin E ◽

Vitamin A ◽

Children And Adolescents ◽

Respiratory Diseases ◽

Respiratory Tract Infections ◽

Vitamin A Deficiency ◽

Serum Vitamin ◽

Vitamin E Deficiency ◽

Tract Infections ◽

Recurrent Respiratory Tract Infections

Abstract Objective To test the association between serum vitamin A and vitamin E and the prevalence of recurrent respiratory tract infections (RRTIs) of children and adolescents. Method A total amount of 5780 children and adolescents aged 2 to 17 were involved, who were classified into:A) Control group ;B) Diagnosed as RRTI with RTI symptoms; C) With RRTI but currently no RTI symptoms being noticed, and D) Not RRTI but showing respiratory disease symptoms. The correlation between serum vitamin A/E level and the presence of RRTIs were analyzed. Results Comparing with the prevalence of RRTI in children with normal vitamin A level, the Odds Ratio(OR) of vitamin A deficiency for RRTIs with symptoms was 8.32 (95%CI: 6.15 ～ 11.27), while the OR of marginal vitamin A deficiency was 1.30 (95%CI: 1.10 ～ 1.55). The OR of vitamin A deficiency or marginal vitamin A deficiency for asymptomatic RRTIs were 1.52 (95%CI: 1.00 ～ 2.32) and 1.30 (95%CI: 1.10 ～ 1.55) respectively, while the OR of vitamin A deficiency or marginal vitamin A deficiency for other respiratory diseases were 7.09 (95%CI: 5.37 ～ 9.37) and 1.60 (95%CI: 1.38 ～ 1.86). Whereas, the OR of vitamin E deficiency or marginal vitamin E deficiency for RRTIs or normal respiratory infections were showed without statistical significance. Conclusion The low level of vitamin A in serum is a risk factor for children and adolescents getting RRTIs or RTIs, indicating a possibly regulatory role of vitamin A in the respiratory diseases. In comparison, the vitamin E deficiency seems to have a weaker but still positive effect on the RRTIs or RTI

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