scholarly journals Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jialiang Yang ◽  
◽  
Tao Huang ◽  
Francesca Petralia ◽  
Quan Long ◽  
...  
Keyword(s):  
Gene Expression ◽  
Complex Disease ◽  
Principal Component ◽  
Tissue Expression ◽  
Whole Body ◽  
Disease Genes ◽  
Related Gene ◽  
Tissue Specific ◽  
Age Related ◽  
Holistic Understanding

Abstract Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed and some essential tissues (e.g., heart and lung) show much stronger “co-aging” than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases.

scholarly journals Aberrant Methylation of Aging-Related Genes in Asthma

2021 ◽  
Vol 8 ◽  
Author(s):  
Yu Yang ◽  
Lin Yuan ◽  
Ming Yang ◽  
Xizi Du ◽  
Ling Qin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pulmonary Function ◽  
Roc Curve ◽  
Peripheral Blood ◽  
Principal Component ◽  
Aberrant Methylation ◽  
Related Gene ◽  
Cpg Sites ◽  
Age Related ◽  
Asthma Patients

Background: Asthma is a complex pulmonary inflammatory disease which is common among older adults. Aging-related alterations have also been found in structural cells and immune cells of asthma patients. Nonetheless, the underlying mechanism by which differenced aging-related gene contributes to asthma pathology remains unclear. Of note, DNA methylation (DNAm) has been proven to play a critical mechanism for age-related gene expression changes. However, the methylation changes of aging-related genes in asthma patients are still obscure.Methods: First, changes in DNAm and gene expression were detected with multiple targeted bisulfite enrichment sequencing (MethTarget) and qPCR in peripheral blood of 51 healthy controls (HCs) and 55 asthmatic patients. Second, the correlation between the DNAm levels of specific altered CpG sites and the pulmonary function indicators of asthma patients was evaluated. Last, the receiver operator characteristic (ROC) curve and principal component analysis (PCA) were used to identify the feasibility of the candidate CpG sites as biomarkers for asthma.Results: Compared with HCs, there was a differential mRNA expression for nine aging-related genes in peripheral blood of asthma patients. Besides, the methylation levels of the nine aging-related genes were also altered in asthma patients, and a total of 68 CpG sites were associated with the severity of asthma. Notably, 9 of the 68 CpG sites were significantly associated with pulmonary function parameters. Moreover, ROC curve and PCA analysis showed that the candidate differential methylation sites (DMSs) can be used as potential biomarkers for asthma.Conclusions: In summary, this study confirmed the differentially expressed mRNA and aberrant DNAm level of aging-related genes in asthma patients. DMSs are associated with the clinical evaluation indicators of asthma, which indicate the involvement of aging-related genes in the pathogenesis of asthma and provide some new possible biomarkers for asthma.

Age-related gene expression and DNA methylation changes in rhesus macaque

Genomics ◽  
2020 ◽  
Vol 112 (6) ◽  
pp. 5147-5156
Author(s):  
Min Zhou ◽  
Liang Zhang ◽  
Qiao Yang ◽  
Chaochao Yan ◽  
Peng Jiang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Rhesus Macaque ◽  
Related Gene ◽  
Age Related

Age-related gene expression change of GABAergic system in visual cortex of rhesus macaque

Gene ◽  
2016 ◽  
Vol 590 (2) ◽  
pp. 227-233 ◽  
Author(s):  
Chenghong Liao ◽  
Qian Han ◽  
Yuanye Ma ◽  
Bing Su
Keyword(s):  
Gene Expression ◽  
Visual Cortex ◽  
Rhesus Macaque ◽  
Gene Expression Change ◽  
Gabaergic System ◽  
Related Gene ◽  
Expression Change ◽  
Age Related

scholarly journals Tissue-specific sex differences in human gene expression

2019 ◽  
Vol 28 (17) ◽  
pp. 2976-2986 ◽  
Author(s):  
Irfahan Kassam ◽  
Yang Wu ◽  
Jian Yang ◽  
Peter M Visscher ◽  
Allan F McRae
Keyword(s):  
Gene Expression ◽  
Sex Differences ◽  
Complex Traits ◽  
Tissue Expression ◽  
Regulatory Elements ◽  
Tissue Specific ◽  
Significance Threshold ◽  
Expression Of Genes ◽  
Causal Variants ◽  
Similar Distance

Abstract Despite extensive sex differences in human complex traits and disease, the male and female genomes differ only in the sex chromosomes. This implies that most sex-differentiated traits are the result of differences in the expression of genes that are common to both sexes. While sex differences in gene expression have been observed in a range of different tissues, the biological mechanisms for tissue-specific sex differences (TSSDs) in gene expression are not well understood. A total of 30 640 autosomal and 1021 X-linked transcripts were tested for heterogeneity in sex difference effect sizes in n = 617 individuals across 40 tissue types in Genotype–Tissue Expression (GTEx). This identified 65 autosomal and 66 X-linked TSSD transcripts (corresponding to unique genes) at a stringent significance threshold. Results for X-linked TSSD transcripts showed mainly concordant direction of sex differences across tissues and replicate previous findings. Autosomal TSSD transcripts had mainly discordant direction of sex differences across tissues. The top cis-expression quantitative trait loci (eQTLs) across tissues for autosomal TSSD transcripts are located a similar distance away from the nearest androgen and estrogen binding motifs and the nearest enhancer, as compared to cis-eQTLs for transcripts with stable sex differences in gene expression across tissue types. Enhancer regions that overlap top cis-eQTLs for TSSD transcripts, however, were found to be more dispersed across tissues. These observations suggest that androgen and estrogen regulatory elements in a cis region may play a common role in sex differences in gene expression, but TSSD in gene expression may additionally be due to causal variants located in tissue-specific enhancer regions.

Training Reverses Age-Related Gene Expression Changes In Skeletal Muscle Of Elderly Men

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S243
Author(s):  
Shlomit Radom-Aizik ◽  
Shlomo Hayek ◽  
Gidi Rechavi ◽  
Ninette Amariglio ◽  
Hillel Halkin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Related Gene ◽  
Elderly Men ◽  
Age Related

scholarly journals Genetic control of age-related gene expression and complex traits in the human brain

2017 ◽  
Author(s):  
Trevor Martin ◽  
Hunter B. Fraser
Keyword(s):  
Gene Expression ◽  
Human Brain ◽  
Neurodegenerative Diseases ◽  
Genetic Variants ◽  
Complex Traits ◽  
Molecular Mechanisms ◽  
Neurological Diseases ◽  
Expression Patterns ◽  
Related Gene ◽  
Age Related

AbstractAge is the primary risk factor for many of the most common human diseases—particularly neurodegenerative diseases—yet we currently have a very limited understanding of how each individual’s genome affects the aging process. Here we introduce a method to map genetic variants associated with age-related gene expression patterns, which we call temporal expression quantitative trait loci (teQTL). We found that these loci are markedly enriched in the human brain and are associated with neurodegenerative diseases such as Alzheimer’s disease and Creutzfeldt-Jakob disease. Examining potential molecular mechanisms, we found that age-related changes in DNA methylation can explain some cis-acting teQTLs, and that trans-acting teQTLs can be mediated by microRNAs. Our results suggest that genetic variants modifying age-related patterns of gene expression, acting through both cis- and trans-acting molecular mechanisms, could play a role in the pathogenesis of diverse neurological diseases.

scholarly journals Age-related Gene Expression and Histologic Changes in Human Nasal Polyps

2019 ◽  
Vol 143 (2) ◽  
pp. AB285
Author(s):  
Seong Ho Cho ◽  
Ara Jo ◽  
Lydia A. Suh ◽  
Roderick G. Carter ◽  
David B. Conley ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nasal Polyps ◽  
Related Gene ◽  
Age Related ◽  
Histologic Changes
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