scholarly journals The Oxidative Stress Markers in the Erythrocytes and Heart Muscle of Obese Rats: Relate to a High-Fat Diet but Not to DJOS Bariatric Surgery

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 183 ◽  
Author(s):  
Bronisława Skrzep-Poloczek ◽  
Jakub Poloczek ◽  
Elżbieta Chełmecka ◽  
Agnieszka Dulska ◽  
Ewa Romuk ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bariatric Surgery ◽  
Heart Muscle ◽  
High Fat Diet ◽  
Glutathione Transferase ◽  
Control Diet ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Stress Markers ◽  
Gpx Activity

Obesity and high-fat diet (HF) are prevalent causes of oxidative stress (OS). Duodenal-jejunal omega switch (DJOS) is a bariatric procedure used for body mass reduction, extensively tested in animal models. We studied the long-term impact of bariatric surgery and an HF diet on the oxidative stress markers in erythrocytes and heart muscles of rats. We analyzed superoxide dismutase (SOD), catalase (CAT), glutathione transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) activity and malondialdehyde (MDA) concentration in DJOS or SHAM (control) operated rats fed with different dietary protocols (control diet (CD) and high-fat diet (HF)), before and after the surgery (CD/CD, HF/HF, CD/HF, and HF/CD). We observed higher erythrocytes CAT, GST and GPx activity in DJOS-operated (vs. SHAM) rats fed with an HF/HF diet. For DJOS-operated rats, erythrocytes CAT and GPx activity and MDA concentration were significantly lower in CD/CD group. We observed increased heart muscle GR activity in SHAM-operated rats (vs. DJOS bariatric surgery) fed with an HF/HF diet. Change from HF to CD diet increased heart muscle GPx activity after DJOS bariatric surgery. Heart muscle SOD activity was lower in HF/HF and CD/CD groups after DJOS bariatric surgery (vs. SHAM). DJOS surgery significantly reduced heart muscle MDA concentration in HF/HF and HF/CD groups (vs. SHAM). We conclude that the selected dietary patterns had a stronger impact on oxidative stress markers in erythrocytes and heart muscle than DJOS bariatric surgery.

Effect of a high sucrose and high fat diet in BDNF (+/-) mice on oxidative stress markers in adipose tissues

2019 ◽  
Vol 665 ◽  
pp. 46-56 ◽  
Author(s):  
Akın Bodur ◽  
İmran İnce ◽  
Cemil Kahraman ◽  
İsmail Abidin ◽  
Selcen Aydin-Abidin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Adipose Tissues ◽  
Stress Markers ◽  
High Sucrose

scholarly journals Metabolic and oxidative stress markers in Wistar rats after 2 months on a high-fat diet

2014 ◽  
Vol 6 (1) ◽  
pp. 130 ◽  
Author(s):  
Nathalie Auberval ◽  
Stéphanie Dal ◽  
William Bietiger ◽  
Michel Pinget ◽  
Nathalie Jeandidier ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Seong-Jong Lee ◽  
Jong-Min Han ◽  
Jin-Seok Lee ◽  
Chang-Gue Son ◽  
Hwi-Jin Im ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Serum Lipid ◽  
Peroxisome Proliferator ◽  
Metabolic Abnormalities ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Peroxisome Proliferator Activated Receptor ◽  
Stress Markers ◽  
And Oxidative Stress

The medicinal plantsArtemisia iwayomogi(A. iwayomogi) andCurcuma longa(C. longa) radix have been used to treat metabolic abnormalities in traditional Korean medicine and traditional Chinese medicine (TKM and TCM). In this study we evaluated the effect of the water extract of a mixture ofA. iwayomogiandC. longa(ACE) on high-fat diet-induced metabolic syndrome in a mouse model. Four groups of C57BL/6N male mice (except for the naive group) were fed a high-fat diet freely for 10 weeks. Among these, three groups (except the control group) were administered a high-fat diet supplemented with ACE (100 or 200 mg/kg) or curcumin (50 mg/kg). Body weight, accumulation of adipose tissues in abdomen and size of adipocytes, serum lipid profiles, hepatic steatosis, and oxidative stress markers were analyzed. ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers. ACE normalized lipid synthesis-associated gene expressions (peroxisome proliferator-activated receptor gamma, PPARγ; fatty acid synthase, FAS; sterol regulatory element-binding transcription factor-1c, SREBP-1c; and peroxisome proliferator-activated receptor alpha, PPARα). The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model.

scholarly journals Renoprotective Effects of PLGA Nanoparticles Loaded with Vitamin E in Wistar Rats, on Hypercaloric Diet

2020 ◽  
Vol 71 (6) ◽  
pp. 230-237
Author(s):  
Adriana Dinu ◽  
Bogdana Virgolici ◽  
Daniela Miricescu ◽  
Alexandra Totan ◽  
Elvira Gagniuc ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Male Rats ◽  
Antioxidant Vitamin ◽  
Standard Diet ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Stress Markers

Obesity is associated with renal lipomatosis, inflammation and oxidative stress. Vitamin E is a liposoluble antioxidant vitamin and PLGA (polylactic-CO-glycolic acid) nanoparticles (NPs) represent a delivery carrier of this vitamin to the abdominal viscera. The aim of this study is to evaluate the renal and systemic effects of PLGA- NPs loaded with vitamin E in high fat diet Wistar rats. Young heathy Wistar male rats (3months old, n=20) were fed for 4 weeks either with standard diet or with high caloric/fat diet. These two experimental groups were divided in two subgroups and for the following 21 days, one group received PLGA-NPs loaded with vitamin E (1 mg/kg) body and the other didn�t. Metabolic serum parameters, oxidative stress markers ( malondialdehyde, MDA and total thiols) from kidney homogenates were measured by spectrophotometric methods. Hematoxylin-eosin stain histopathologic examination of kidneys was performed. The obesogenic diet increased the serum levels for triglycerides (p[0.001) and renal function markers: urea (p[0.02), creatinine (p[0.02) and cystatin (p[0.01). The treatment reduced the kidney inflammation, prevented tubulonephrosis damage and improved the renal oxidative stress markers (p[0.05) in the high fat diet group. In conclusion, PLGA-NPs loaded with vitamin E had renoprotective effect in high fat diet Wistar rats.

scholarly journals Effects of a Mixed Limosilactobacillus fermentum Formulation with Claimed Probiotic Properties on Cardiometabolic Variables, Biomarkers of Inflammation and Oxidative Stress in Male Rats Fed a High-Fat Diet

Foods ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2202
Author(s):  
Micaelle Oliveira de Luna Freire ◽  
Luciana Caroline Paulino do Nascimento ◽  
Kataryne Árabe Rimá de Oliveira ◽  
Alisson Macário de Oliveira ◽  
Thiago Henrique Napoleão ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Control Diet ◽  
Male Rats ◽  
Control Group ◽  
Low Grade ◽  
Probiotic Properties ◽  
High Fat ◽  
Low Grade Inflammation ◽  
And Oxidative Stress

High-fat diet (HFD) consumption has been linked to dyslipidemia, low-grade inflammation and oxidative stress. This study investigated the effects of a mixed formulation with Limosilactobacillusfermentum 139, L. fermentum 263 and L. fermentum 296 on cardiometabolic parameters, fecal short-chain fatty acid (SCFA) contents and biomarkers of inflammation and oxidative stress in colon and heart tissues of male rats fed an HFD. Male Wistar rats were grouped into control diet (CTL, n = 6), HFD (n = 6) and HFD with L. fermentum formulation (HFD-Lf, n = 6) groups. The L.fermentum formulation (1 × 109 CFU/mL of each strain) was administered twice a day for 4 weeks. After a 4-week follow-up, biochemical parameters, fecal SCFA, cytokines and oxidative stress variables were evaluated. HFD consumption caused hyperlipidemia, hyperglycemia, low-grade inflammation, reduced fecal acetate and propionate contents and increased biomarkers of oxidative stress in colon and heart tissues when compared to the CTL group. Rats receiving the L. fermentum formulation had reduced hyperlipidemia and hyperglycemia, but similar SCFA contents in comparison with the HFD group (p < 0.05). Rats receiving the L. fermentum formulation had increased antioxidant capacity throughout the colon and heart tissues when compared with the control group. Administration of a mixed L. fermentum formulation prevented hyperlipidemia, inflammation and oxidative stress in colon and heart tissues induced by HFD consumption.

scholarly journals Strawberry modulates oxidative stress markers in response to high fat meal in overweight men and women

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Amanda Linares ◽  
Dianne Hyson ◽  
Tissa Kappagoda ◽  
Britt Burton‐Freeman
Keyword(s):  
Oxidative Stress ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Men And Women ◽  
Stress Markers ◽  
Fat Meal
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