A diarylethene as the SO2 gas generator upon UV irradiation

2015 ◽  
Vol 51 (9) ◽  
pp. 1736-1738 ◽  
Author(s):  
Ryuhei Kodama ◽  
Kimio Sumaru ◽  
Kana Morishita ◽  
Toshiyuki Kanamori ◽  
Kengo Hyodo ◽  
...  

A thermally stable closed-ring isomer of a diarylethene having a sulfone group works as the SO2 gas generator upon UV irradiation; photoisomerization followed by generation of SO2 gas to induce cell death.

2017 ◽  
Author(s):  
Ellen Sletten ◽  
Rachael A. Day ◽  
Daniel A. Estabrook ◽  
Jessica K. Logan

<p>Photodynamic therapy (PDT) requires photosensitizer, light, and oxygen to induce cell death. The majority of efforts to advance PDT focus only on the first two components. Here, we employ perfluorocarbon nanoemulsions to simultaneously deliver oxygen and photosensitizer. We find that the implementation of fluorous soluble photosensitizers enhances the efficacy of PDT. </p>


2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Viktorija Juric ◽  
Lance Hudson ◽  
Joanna Fay ◽  
Cathy E. Richards ◽  
Hanne Jahns ◽  
...  

AbstractActivation of cyclin-dependent kinases (CDKs) contributes to the uncontrolled proliferation of tumour cells. Genomic alterations that lead to the constitutive activation or overexpression of CDKs can support tumourigenesis including glioblastoma (GBM), the most common and aggressive primary brain tumour in adults. The incurability of GBM highlights the need to discover novel and more effective treatment options. Since CDKs 2, 7 and 9 were found to be overexpressed in GBM, we tested the therapeutic efficacy of two CDK inhibitors (CKIs) (CYC065 and THZ1) in a heterogeneous panel of GBM patient-derived cell lines (PDCLs) cultured as gliomaspheres, as preclinically relevant models. CYC065 and THZ1 treatments suppressed invasion and induced viability loss in the majority of gliomaspheres, irrespective of the mutational background of the GBM cases, but spared primary cortical neurons. Viability loss arose from G2/M cell cycle arrest following treatment and subsequent induction of apoptotic cell death. Treatment efficacies and treatment durations required to induce cell death were associated with proliferation velocities, and apoptosis induction correlated with complete abolishment of Mcl-1 expression, a cell cycle-regulated antiapoptotic Bcl-2 family member. GBM models generally appeared highly dependent on Mcl-1 expression for cell survival, as demonstrated by pharmacological Mcl-1 inhibition or depletion of Mcl-1 expression. Further analyses identified CKI-induced Mcl-1 loss as a prerequisite to establish conditions at which the BH3-only protein Bim can efficiently induce apoptosis, with cellular Bim amounts strongly correlating with treatment efficacy. CKIs reduced proliferation and promoted apoptosis also in chick embryo xenograft models of primary and recurrent GBM. Collectively, these studies highlight the potential of these novel CKIs to suppress growth and induce cell death of patient-derived GBM cultures in vitro and in vivo, warranting further clinical investigation.


Author(s):  
Krissia Franco de Godoy ◽  
Joice Margareth de Almeida Rodolpho ◽  
Patrícia Brassolatti ◽  
Bruna Dias de Lima Fragelli ◽  
Cynthia Aparecida de Castro ◽  
...  

FEBS Letters ◽  
2000 ◽  
Vol 475 (2) ◽  
pp. 71-77 ◽  
Author(s):  
Ruth Granoth ◽  
Mati Fridkin ◽  
Sara Rubinraut ◽  
Illana Gozes

2008 ◽  
Vol 103 (5) ◽  
Author(s):  
Alexandra E. Ewence ◽  
Martin Bootman ◽  
H. Llewelyn Roderick ◽  
Jeremy N. Skepper ◽  
Geraldine McCarthy ◽  
...  

2017 ◽  
Vol 309 ◽  
pp. 88-99 ◽  
Author(s):  
Robert P. Lisak ◽  
Liljana Nedelkoska ◽  
Joyce A. Benjamins ◽  
Dana Schalk ◽  
Beverly Bealmear ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document