Multifunctional magnetic silica nanotubes for MR imaging and targeted drug delivery

2015 ◽  
Vol 51 (18) ◽  
pp. 3923-3926 ◽  
Author(s):  
Liang Huang ◽  
Lijiao Ao ◽  
Wei Wang ◽  
Dehong Hu ◽  
Zonghai Sheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mr Imaging ◽  
Targeted Drug Delivery ◽  
Sustained Drug Release ◽  
Silica Nanotubes ◽  
Magnetic Nanotubes ◽  
Magnetic Silica ◽  
Targeted Drug

Magnetic nanotubes with strong superparamagnetism and sustained drug release were fabricated for MR imaging and magnetically guided/cancer targeted drug delivery.

scholarly journals A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1970 ◽  
Author(s):  
Humaira Idrees ◽  
Syed Zohaib Javaid Zaidi ◽  
Aneela Sabir ◽  
Rafi Ullah Khan ◽  
Xunli Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Natural Polymer ◽  
Natural Polymers ◽  
Sustained Drug Release ◽  
Delivery Methods ◽  
Lower Toxicity ◽  
Targeted Drug

Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

Programmable shape-morphing microrobots for localized cancer cells treatment

2021 ◽  
Author(s):  
Chen Xin ◽  
Dongdong Jin ◽  
Yanlei Hu ◽  
Liang Yang ◽  
Rui Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Biological Applications ◽  
Proof Of Concept ◽  
Ph Responsive ◽  
Solution Ph ◽  
Shape Morphing ◽  
On Demand ◽  
Targeted Drug

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

Cationic polyelectrolyte grafted mesoporous magnetic silica composite particles for targeted drug delivery and thrombolysis

Materialia ◽  
2020 ◽  
Vol 11 ◽  
pp. 100676
Author(s):  
Khorsheda A. Bithi ◽  
Hideto Minami ◽  
Mohammad K. Hossain ◽  
Mohammad M. Rahman ◽  
Mohammad A. Rahman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Cationic Polyelectrolyte ◽  
Composite Particles ◽  
Silica Composite ◽  
Magnetic Silica ◽  
Targeted Drug

Light-responsive polymersomes with a charge-switch for targeted drug delivery

2020 ◽  
Vol 8 (4) ◽  
pp. 727-735 ◽  
Author(s):  
Yaowu Zhou ◽  
Rongrong Chen ◽  
Huiting Yang ◽  
Chunyan Bao ◽  
Jinyan Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Amphiphilic Polymer ◽  
Targeted Drug ◽  
A Charge

A cationic and lipid-like amphiphilic polymer was designed to form polymersomes for photo-responsive and targeted drug release.

scholarly journals A photochemical approach for controlled drug release in targeted drug delivery

2012 ◽  
Vol 20 (3) ◽  
pp. 1281-1290 ◽  
Author(s):  
Seok Ki Choi ◽  
Manisha Verma ◽  
Justin Silpe ◽  
Ryan E. Moody ◽  
Kenny Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Controlled Drug Release ◽  
Targeted Drug

scholarly journals Folic acid modified Fe3O4 nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging

RSC Advances ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 5294-5303 ◽  
Author(s):  
Meng-Yu Fei ◽  
Meng-Meng Song ◽  
Pei Wang ◽  
Gao-zong Pang ◽  
Jing Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Mr Imaging ◽  
Targeted Drug Delivery ◽  
Water Soluble ◽  
Ultrasonic Technique ◽  
One Step ◽  
Targeted Drug

Water-soluble Fe3O4@F127@FA nanoclusters were prepared by a facile ultrasonic-treated method for MR imaging and targeted drug delivery.

Colon-Targeted Drug Delivery Microparticles Prepared Using Electrohydrodynamic Atomization

2011 ◽  
Vol 130-134 ◽  
pp. 1663-1667
Author(s):  
Deng Guang Yu ◽  
Xia Wang ◽  
Ping Lu ◽  
Xiao Chen ◽  
Hui Peng Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Amorphous State ◽  
In Vitro Dissolution ◽  
Infrared Analysis ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Scanning Calorimetry ◽  
Electrohydrodynamic Atomization ◽  
Targeted Drug

Electrohydrodynamic atomization (EHDA) process was exploited to prepare drug-loaded microparticles for colon-targeted drug delivery. Field emission scanning electron microscope results showed that the particles had a size of 1.3±0.7 μm. Differential scanning calorimetry (DSC) analyses and wide-angle X-ray diffraction analyses (XRD) results similarly demonstrated that the drug DS had been totally converted into an amorphous state in the EHDA microparticles with Eudragit® L-100 as the polymer matrix. Attenuated total reflectance Fourier transform infrared analysis disclosed that the secondary interactions presented between DS and Eudragit® L100 molecules. In vitro dissolution tests verified that the microparticles had a pH-dependent and sustained drug release profile. The present study provides an easy way for developing colon-targeted drug delivery microparticles.

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