Integration of lateral porous silicon membranes into planar microfluidics

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 833-838 ◽  
Author(s):  
Thierry Leïchlé ◽  
David Bourrier
Keyword(s):  
Porous Silicon ◽  
Fabrication Process ◽  
Microfluidic Channels ◽  
Dead End ◽  
Silicon Membranes ◽  
On Chip ◽  
Mesoporous Membranes

A unique fabrication process was developed to integrate lateral porous silicon membranes into planar microfluidic channels. These mesoporous membranes were demonstrated to be suitable for on-chip dead-end microfiltration.

scholarly journals Versatile and Automated 3D Polydimethylsiloxane (PDMS) Patterning for Large-Scale Fabrication of Organ-on-Chip (OOC) Components

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 873
Author(s):  
Nikolas Gaio ◽  
Sebastiaan Kersjes ◽  
William Quiros Solano ◽  
Pasqualina Sarro ◽  
Ronald Dekker
Keyword(s):  
Large Scale ◽  
Silicon Wafers ◽  
Fabrication Process ◽  
Microfluidic Channels ◽  
3D Structures ◽  
3 Dimensional ◽  
Ic Packaging ◽  
Thin Membranes ◽  
On Chip

We present a reproducible process to directly pattern 3-Dimensional (3D) polydimethylsiloxane (PDMS) structures for Organ-on-Chips (OOC) via automated molding. The presented process employs a commercially available system from IC packaging improving the fabrication process for microfluidic channels and thin membranes, which are components frequently used in OOCs. The process removes the manual steps used previously in the fabrication of microfluidic channels and improves the control over the thickness of the PDMS layers. The process was also employed to fabricate and pattern thin PDMS membranes on silicon wafers, without the use of lithography and etching steps and in combination with 3D structures. The use of foil assisted molding techniques presented in this work is an important step toward the large-scale manufacturing of OOCs.

High-throughput acoustofluidic microchannels for single cell rotation

2021 ◽  
Author(s):  
Junwen Zhu ◽  
Qiqian Zhang ◽  
Fei Liang ◽  
Yongxiang Feng ◽  
Wenhui Wang
Keyword(s):  
High Throughput ◽  
Low Cost ◽  
Rotation Velocity ◽  
Microfluidic Channels ◽  
Lab On Chip ◽  
Dead End ◽  
Cell Rotation ◽  
Fabrication Procedure ◽  
On Chip ◽  
Highly Uniform

Abstract There is a growing desire for cell rotation in the field of biophysics, bioengineering and biomedicine. We herein present novel microfluidic channels for simultaneous high-throughput cell self-rotation using local circular streaming generated by ultrasonic wave excited bubble arrays. The bubble traps achieve high homogeneity of liquid-gas interface by setting capillary valves at the entrances of dead-end bubble trappers orthogonal to the main microchannel. In such a highly uniform bubble array, rotation at different fields of bubble-relevant vortices is considered equal and interconvertible. The device is compatible with cells of various size and retains manageable rotation velocity when actuated by signals of varying frequency and voltage. Experimental observations were confirmed consistent with theoretical estimation and numerical simulation. Comparing with the conventional approaches of cell rotation, our device has multiple merits such as high throughput, low cost and simple fabrication procedure, and high compatibility for lab-on-chip integration. Therefore, the platform holds a promise in cell observation, medicine development and biological detection.

Lateral porous silicon membranes with tunable pore size for on-chip separation

2016 ◽  
Author(s):  
Yingning He ◽  
David Bourrier ◽  
Eric Imbernon ◽  
Adhitya Bhaswara ◽  
Xavier Dollat ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Pore Size ◽  
Silicon Membranes ◽  
On Chip ◽  
Chip Separation

scholarly journals Design Methodology of Passive In-Line Relays for Molecular Communication in Flow-Induced Microfluidic Channel

Biosensors ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 65
Author(s):  
Puneet Manocha ◽  
Gitanjali Chandwani
Keyword(s):  
Communication System ◽  
Communication Systems ◽  
Microfluidic Channel ◽  
Microfluidic Channels ◽  
Molecular Communication ◽  
External Energy ◽  
Lab On Chip ◽  
Molecular Communication Systems ◽  
Macro Scale ◽  
On Chip

Molecular communication is a bioinspired communication that enables macro-scale, micro-scale and nano-scale devices to communicate with each other. The molecular communication system is prone to severe signal attenuation, dispersion and delay, which leads to performance degradation as the distance between two communicating devices increases. To mitigate these challenges, relays are used to establish reliable communication in microfluidic channels. Relay assisted molecular communication systems can also enable interconnection among various entities of the lab-on-chip for sharing information. Various relaying schemes have been proposed for reliable molecular communication systems, most of which lack practical feasibility. Thus, it is essential to design and develop relays that can be practically incorporated into the microfluidic channel. This paper presents a novel design of passive in-line relay for molecular communication system that can be easily embedded in the microfluidic channel and operate without external energy. Results show that geometric modification in the microfluidic channel can act as a relay and restore the degraded signal up-to 28%.

scholarly journals Silicon-Quartz Microcapillary Opto-Fluidic Platform Obtained by CMOS-Compatible Die to Wafer 200 mm Dual Bonding Process

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 1018
Author(s):  
Giuseppe Fiorentino ◽  
Ben Jones ◽  
Sophie Roth ◽  
Edith Grac ◽  
Murali Jayapala ◽  
...  
Keyword(s):  
Adhesive Bonding ◽  
System Analysis ◽  
Quartz Substrate ◽  
Microfluidic System ◽  
Bonding Process ◽  
Microfluidic Channels ◽  
Fully Integrated ◽  
Lab On Chip ◽  
Human Blood Cells ◽  
On Chip

A composite, capillary-driven microfluidic system suitable for transmitted light microscopy of cells (e.g., red and white human blood cells) is fabricated and demonstrated. The microfluidic system consists of a microchannels network fabricated in a photo-patternable adhesive polymer on a quartz substrate, which, by means of adhesive bonding, is then connected to a silicon microfluidic die (for processing of the biological sample) and quartz die (to form the imaging chamber). The entire bonding process makes use of a very low temperature budget (200 °C). In this demonstrator, the silicon die consists of microfluidic channels with transition structures to allow conveyance of fluid utilizing capillary forces from the polymer channels to the silicon channels and back to the polymer channels. Compared to existing devices, this fully integrated platform combines on the same substrate silicon microfluidic capabilities with optical system analysis, representing a portable and versatile lab-on-chip device.

scholarly journals Fabrication of Porous Silicon Based Humidity Sensing Elements on Paper

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Tero Jalkanen ◽  
Anni Määttänen ◽  
Ermei Mäkilä ◽  
Jaani Tuura ◽  
Martti Kaasalainen ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Smart Cities ◽  
Low Cost ◽  
Electrical Characterization ◽  
Fabrication Process ◽  
Sensing Element ◽  
Paper Substrate ◽  
Roll To Roll ◽  
Silver Electrodes ◽  
Silicon Based

A roll-to-roll compatible fabrication process of porous silicon (pSi) based sensing elements for a real-time humidity monitoring is described. The sensing elements, consisting of printed interdigitated silver electrodes and a spray-coated pSi layer, were fabricated on a coated paper substrate by a two-step process. Capacitive and resistive responses of the sensing elements were examined under different concentrations of humidity. More than a three orders of magnitude reproducible decrease in resistance was measured when the relative humidity (RH) was increased from 0% to 90%. A relatively fast recovery without the need of any refreshing methods was observed with a change in RH. Humidity background signal and hysteresis arising from the paper substrate were dependent on the thickness of sensing pSi layer. Hysteresis in most optimal sensing element setup (a thick pSi layer) was still noticeable but not detrimental for the sensing. In addition to electrical characterization of sensing elements, thermal degradation and moisture adsorption properties of the paper substrate were examined in connection to the fabrication process of the silver electrodes and the moisture sensitivity of the paper. The results pave the way towards the development of low-cost humidity sensors which could be utilized, for example, in smart packaging applications or in smart cities to monitor the environment.

Porous silicon membranes for gas-sensor applications

1995 ◽  
Vol 46 (1-3) ◽  
pp. 43-46 ◽  
Author(s):  
T. Taliercio ◽  
M. Dilhan ◽  
E. Massone ◽  
A. Foucaran ◽  
A.M. Gué ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Gas Sensor ◽  
Sensor Applications ◽  
Silicon Membranes

Microfluidic Gas Sensing with Living Microbial Cells Confined in a Microaquarium

2013 ◽  
Vol 543 ◽  
pp. 431-434 ◽  
Author(s):  
Kazunari Ozasa ◽  
Jee Soo Lee ◽  
Simon Song ◽  
Masahiko Hara ◽  
Mizuo Maeda
Keyword(s):  
Real Time ◽  
Concentration Gradient ◽  
Gas Sensing ◽  
Bacterial Chemotaxis ◽  
Optical Microscope ◽  
Sensor Chip ◽  
Microfluidic Channels ◽  
Microbial Cells ◽  
Gas Molecules ◽  
On Chip

We investigated on-chip cytotoxicity gas sensing using the bacterial chemotaxis of Euglena confined in a microaquarium. The sensor chip made from PDMS had one microaquarium and two microfluidic channels passing aside of the microaquarium. The chemotactic microbial cells were confined in the microaquarium, whereas two gases (one sample and one reference) flowed in the two isolated microchannels. Gas molecules move from the microchannels into the microaquarium by permeation through porous PDMS wall, and dissolve into the water in the microaquarium, where Euglena cells are swimming. The chemotactic movements of Euglena were observed with an optical microscope and measured as traces in real time. By injecting CO2 and air into each microchannel separately, the Euglena cells in the microaquarium moved to air side, escaping from CO2. This observation showed that the concentration gradient of CO2 was produced in the water in the microaquarium. The CO2-avoiding movement of Euglena was increased largely at a CO2 concentration of 40%, and then moderately increased above 60%. Some Euglena cells stopped swimming at the air side of the microaquarium and remained there even after CO2 has been removed, which can be used as the indicator of CO2 history.

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