scholarly journals Amine-modified hyaluronic acid-functionalized porous silicon nanoparticles for targeting breast cancer tumors

Nanoscale ◽  
2014 ◽  
Vol 6 (17) ◽  
pp. 10377-10387 ◽  
Author(s):  
Patrick V. Almeida ◽  
Mohammad-Ali Shahbazi ◽  
Ermei Mäkilä ◽  
Martti Kaasalainen ◽  
Jarno Salonen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Porous Silicon ◽  
Silicon Nanoparticles ◽  
Porous Silicon Nanoparticles

Synthesis of amine-modified hyaluronic acid porous silicon nanoparticles resulted in a suitable and promising nanodelivery system for the targeting of CD44-overexpressing tumors.

Cyclodextrin-Modified Porous Silicon Nanoparticles for Efficient Sustained Drug Delivery and Proliferation Inhibition of Breast Cancer Cells

2015 ◽  
Vol 7 (41) ◽  
pp. 23197-23204 ◽  
Author(s):  
Alexandra Correia ◽  
Mohammad-Ali Shahbazi ◽  
Ermei Mäkilä ◽  
Sérgio Almeida ◽  
Jarno Salonen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Porous Silicon ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Silicon Nanoparticles ◽  
Proliferation Inhibition ◽  
Sustained Drug Delivery ◽  
Porous Silicon Nanoparticles

scholarly journals Site-Specific 111In-Radiolabeling of Dual-PEGylated Porous Silicon Nanoparticles and Their In Vivo Evaluation in Murine 4T1 Breast Cancer Model

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 686 ◽  
Author(s):  
Dave Lumen ◽  
Simo Näkki ◽  
Surachet Imlimthan ◽  
Elisavet Lambidis ◽  
Mirkka Sarparanta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Porous Silicon ◽  
Silicon Nanoparticles ◽  
Click Reaction ◽  
Circulation Time ◽  
In Vivo Evaluation ◽  
Site Specific ◽  
Porous Silicon Nanoparticles ◽  
4T1 Breast Cancer

Polyethylene glycol (PEG) has been successfully used for improving circulation time of several nanomaterials but prolonging the circulation of porous silicon nanoparticles (PSi NPs) has remained challenging. Here, we report a site specific radiolabeling of dual-PEGylated thermally oxidized porous silicon (DPEG-TOPSi) NPs and investigation of influence of the PEGylation on blood circulation time of TOPSi NPs. Trans-cyclooctene conjugated DPEG-TOPSi NPs were radiolabeled through a click reaction with [111In]In-DOTA-PEG4-tetrazine (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and the particle behavior was evaluated in vivo in Balb/c mice bearing 4T1 murine breast cancer allografts. The dual-PEGylation significantly prolonged circulation of [111In]In-DPEG-TOPSi particles when compared to non-PEGylated control particles, yielding 10.8 ± 1.7% of the injected activity/g in blood at 15 min for [111In]In-DPEG-TOPSi NPs. The improved circulation time will be beneficial for the accumulation of targeted DPEG-TOPSi to tumors.

Fusogenic porous silicon nanoparticles as a broad-spectrum immunotherapy against bacterial infections

2021 ◽  
Author(s):  
Byungji Kim ◽  
Qinglin Yang ◽  
Leslie W. Chan ◽  
Sangeeta N. Bhatia ◽  
Erkki Ruoslahti ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Broad Spectrum ◽  
Therapeutic Efficacy ◽  
Bacterial Infections ◽  
Silicon Nanoparticles ◽  
First Line ◽  
Gram Positive ◽  
Gram Negative ◽  
Porous Silicon Nanoparticles

RNAi-mediated immunotherapy provided by fusogenic porous silicon nanoparticles demonstrates superior therapeutic efficacy against both Gram-positive and Gram-negative bacterial infections compared with first-line antibiotics.

scholarly journals Tracking the Fate of Porous Silicon Nanoparticles Delivering a Peptide Payload by Intrinsic Photoluminescence Lifetime

2018 ◽  
Vol 30 (35) ◽  
pp. 1802878 ◽  
Author(s):  
Yusung Jin ◽  
Dokyoung Kim ◽  
Hajung Roh ◽  
Sojeong Kim ◽  
Sazid Hussain ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Silicon Nanoparticles ◽  
Porous Silicon Nanoparticles ◽  
Photoluminescence Lifetime

scholarly journals Ex vivo biodistribution of gallium-68-labeled porous silicon nanoparticles

2020 ◽  
Vol 1439 ◽  
pp. 012035
Author(s):  
V K Tishchenko ◽  
V. M. Petriev ◽  
A A Mikhailovskaya ◽  
O A Smoryzanova ◽  
A V Kabashin ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Silicon Nanoparticles ◽  
Ex Vivo ◽  
Porous Silicon Nanoparticles ◽  
Gallium 68 ◽  
Ex Vivo Biodistribution

scholarly journals Transferrin-targeted porous silicon nanoparticles reduce glioblastoma cell migration across tight extracellular space

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sana Sheykhzadeh ◽  
Meihua Luo ◽  
Bo Peng ◽  
Jacinta White ◽  
Youssef Abdalla ◽  
...  
Keyword(s):  
Cell Migration ◽  
Porous Silicon ◽  
Extracellular Space ◽  
Silicon Nanoparticles ◽  
Glioblastoma Cell ◽  
Porous Silicon Nanoparticles
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