Copper-catalysed reductive amination of nitriles and organic-group reductions using dimethylamine borane

RSC Advances ◽  
2014 ◽  
Vol 4 (94) ◽  
pp. 51845-51849 ◽  
Author(s):  
Dominic van der Waals ◽  
Alan Pettman ◽  
Jonathan M. J. Williams
Keyword(s):  
Convenient Method ◽  
Reductive Amination ◽  
Copper Catalyst ◽  
Organic Group ◽  
Dimethylamine Borane

A mild convenient method for the aqueous reduction of a range of organic functionalities and the reductive amination of nitriles using a heterogeneous copper catalyst formed in situ.

ChemInform Abstract: Copper-Catalyzed Reductive Amination of Nitriles and Organic-Group Reductions Using Dimethylamine Borane.

ChemInform ◽  
2015 ◽  
Vol 46 (16) ◽  
pp. no-no
Author(s):  
Dominic van der Waals ◽  
Alan Pettman ◽  
Jonathan M. J. Williams
Keyword(s):  
Reductive Amination ◽  
Organic Group ◽  
Dimethylamine Borane

Rotary Beveling for In Situ Thin-Section Microscopy of Cell Cultures

1981 ◽  
Vol 39 ◽  
pp. 550-551
Author(s):  
Dean A. Handley ◽  
Jack T. Alexander ◽  
Shu Chien
Keyword(s):  
Cell Growth ◽  
Cell Cultures ◽  
Molecular Interactions ◽  
Convenient Method ◽  
Petri Dish ◽  
Simple Method ◽  
Thin Section Microscopy ◽  
Thin Sectioning ◽  
Organic Fluids

In situ preparation of cell cultures for ultrastructural investigations is a convenient method by which fixation, dehydration and embedment are carried out in the culture petri dish. The in situ method offers the advantage of preserving the native orientation of cell-cell interactions, junctional regions and overlapping configurations. In order to section after embedment, the petri dish is usually separated from the polymerized resin by either differential cryo-contraction or solvation in organic fluids. The remaining resin block must be re-embedded before sectioning. Although removal of the petri dish may not disrupt the native cellular geometry, it does sacrifice what is now recognized as an important characteristic of cell growth: cell-substratum molecular interactions. To preserve the topographic cell-substratum relationship, we developed a simple method of tapered rotary beveling to reduce the petri dish thickness to a dimension suitable for direct thin sectioning.

In Situ XAFS and NMR Study of Rhodium-Catalyzed Dehydrogenation of Dimethylamine Borane

2005 ◽  
Vol 127 (10) ◽  
pp. 3254-3255 ◽  
Author(s):  
Yongsheng Chen ◽  
John L. Fulton ◽  
John C. Linehan ◽  
Tom Autrey
Keyword(s):  
Nmr Study ◽  
In Situ Xafs ◽  
Dimethylamine Borane

In situ monitoring of PISA morphologies

2021 ◽  
Author(s):  
Julia Y. Rho ◽  
Georg M. Scheutz ◽  
Satu Häkkinen ◽  
John B. Garrison ◽  
Qiao Song ◽  
...  
Keyword(s):  
Convenient Method ◽  
Self Assembly ◽  
In Situ Monitoring ◽  
Fluorescent Spectroscopy

Fluorescent spectroscopy is a convenient method for monitoring the progression of polymerization-induced self-assembly (PISA).

Oxidative Carbonylation of Methanol to Dimethyl Carbonate by Chlorine-Free Homogeneous and Immobilized 2,2'-Bipyrimidine Modified Copper Catalyst

2007 ◽  
Vol 72 (8) ◽  
pp. 1094-1106 ◽  
Author(s):  
Szilárd Csihony ◽  
László T. Mika ◽  
Gábor Vlád ◽  
Katalin Barta ◽  
Christian P. Mehnert ◽  
...  
Keyword(s):  
High Pressure ◽  
Dimethyl Carbonate ◽  
Copper Catalyst ◽  
Catalytic Performance ◽  
Spectroscopic Studies ◽  
Oxidative Carbonylation ◽  
Cu Catalyst

A chlorine-free catalyst, prepared in situ from Cu(II) acetate and 2,2'-bipyrimidine, can be used for the oxidative carbonylation of methanol to dimethyl carbonate. In situ high pressure IR and NMR spectroscopic studies suggest the formation of [Cu(2,2'-bipyrimidine)(CO)- (OMe)] as one of the key intermediates. The catalytic performance of the 2,2'-bipyrimidine-modified Cu-catalyst is similar to the CuCl-based system. The chlorine free catalyst can be immobilized by using the copolymer of 5-vinyl-2,2'-bipyrimidine and styrene.

Intramolecular Michael Addition of N- and O-Centred Nucleophiles to Tethered Acrylates. The Role of Double-Bond Geometry in Controlling the Diastereo- selectivity of Cyclizations Leading to 2,6-Disubstituted Tetrahydropyrans and Piperidines.

1998 ◽  
Vol 51 (1) ◽  
pp. 9 ◽  
Author(s):  
Martin G. Banwell ◽  
Brett D. Bissett ◽  
Chinh T. Bui ◽  
Ha T. T. Pham ◽  
Gregory W. Simpson
Keyword(s):  
Double Bond ◽  
Total Synthesis ◽  
Michael Addition ◽  
Reductive Amination ◽  
Major Product ◽  
Enantioselective Synthesis ◽  
Cyclization Reactions ◽  
Glandular Secretion

The oxyanion derived from hydroxyacrylate E-(5) undergoes smooth intramolecular Michael addition to give the trans-2,6-disubstituted tetrahydropyran (7) as the major product of reaction. In contrast, the oxyanion obtained from isomer Z-(5) cyclizes to give the cis-2,6-disubstituted tetrahydropyran (6) as the major product. Such chemistry has been extended to the enantioselective synthesis of (+)-(6) the acquisition of which constitutes a formal total synthesis of acid (+)-(2), a constituent of the glandular secretion from the civet cat (Viverra civetta). Reductive amination of keto acrylate (12) affords an intermediate amine which cyclizes, in situ, to give the cis-2,6-disubstituted piperidine (26). Analogous treatment of compound (13) delivers the isomeric trans-2,6-disubstituted piperidine (27) as the exclusive product of reaction. Transition state structures have been proposed to account for the diastereoselectivities observed in all of the cyclization reactions.

A highly active copper catalyst for the hydrogenation of carbon dioxide to formate under ambient conditions

2020 ◽  
Vol 49 (9) ◽  
pp. 2994-3000
Author(s):  
Karan Chaudhary ◽  
Manoj Trivedi ◽  
D. T. Masram ◽  
Abhinav Kumar ◽  
Girijesh Kumar ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Copper Catalyst ◽  
Catalytic Conversion ◽  
Ambient Conditions ◽  
Turnover Number ◽  
Highly Active ◽  
Tin Metal ◽  
Hydrogenation Of Carbon Dioxide

Catalytic conversion of CO2via hydrogenation using in situ gaseous H2 (granulated tin metal and concentrated HCl) to produce the formate salt (HCO2−) with turnover number (TON) values of 326 to 1.065 × 105 in 12 h to 48 h of reaction at 25 °C to 80 °C has been reported.

In situ FT-IR Investigation of Formic Acid Adsorption on Reduced and Reoxidized Copper Catalysts

1994 ◽  
Vol 48 (7) ◽  
pp. 827-832 ◽  
Author(s):  
Graeme J. Millar ◽  
David Newton ◽  
Graham A. Bowmaker ◽  
Ralph P. Cooney
Keyword(s):  
Activation Energy ◽  
Formic Acid ◽  
Maximum Rate ◽  
Heterogeneous Catalysts ◽  
Copper Catalyst ◽  
Copper Catalysts ◽  
Copper Surface ◽  
Desorption Activation Energy ◽  
Ft Ir

An in situ infrared cell capable of studying reactions over heterogeneous catalysts in the temperature range 77 to 773 K has been designed. In particular, the adsorption of formic acid on a model Cu/SiO2 methanol synthesis catalyst was investigated. Exposure of a reduced copper surface to formic acid at 300 K resulted in the formation of both formic acid molecules, which were ligated to the copper catalyst, and chemisorbed bidentate copper formate species. Under temperature-programming conditions, the bidentate species displayed a maximum rate of desorption at 433 K, which correlates to a desorption activation energy of 120 kJ mol−1. In contrast, on the reoxidized catalyst, unidentate formate species were preferentially formed. These exhibited a maximum rate of desorption at a temperature of 408 K, and a desorption activation energy of 113 kJ mol−1. A mechanism was postulated to explain this behavior, and evidence was presented to show that useful kinetic data can be obtained for desorption from a catalyst in the form of a pressed disk.

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