Modulating the photo-exciting process of photosensitizer to improve in vitro phototoxicity by preparing its self-assembly nanostructures

RSC Advances ◽  
2015 ◽  
Vol 5 (4) ◽  
pp. 2794-2805 ◽  
Author(s):  
Lin Zhou ◽  
Xuefeng Ge ◽  
Jiahong Zhou ◽  
Shaohua Wei ◽  
Jian Shen
Keyword(s):  
Self Assembly ◽  
Photodynamic Activity ◽  
Charge Property ◽  
Self Assembled

Self-assembled photosensitizer nanostructures preparation by controlling the charge property of drug and ion strength of environment to improve photodynamic activity.

Sulfanyl porphyrazines: Molecular barrel-like self-assembly in crystals, optical properties and in vitro photodynamic activity towards cancer cells

2017 ◽  
Vol 136 ◽  
pp. 898-908 ◽  
Author(s):  
Jaroslaw Piskorz ◽  
Sebastian Lijewski ◽  
Mateusz Gierszewski ◽  
Karolina Gorniak ◽  
Lukasz Sobotta ◽  
...  
Keyword(s):  
Optical Properties ◽  
Cancer Cells ◽  
Self Assembly ◽  
Photodynamic Activity

scholarly journals Synthesis, solid state self-assembly driven by antiparallel π⋯π stacking and {⋯H–C–C–F}2 dimer synthons, and in vitro acetyl cholinesterase inhibition activity of phenoxy pendant isatins

RSC Advances ◽  
2022 ◽  
Vol 12 (3) ◽  
pp. 1788-1796
Author(s):  
Saba Mehreen ◽  
Aman Ullah ◽  
Humaira Nadeem ◽  
Necmi Dege ◽  
Muhammad Moazzam Naseer
Keyword(s):  
Solid State ◽  
Self Assembly ◽  
Cholinesterase Inhibition ◽  
Inhibition Activity ◽  
State Structure ◽  
Acetyl Cholinesterase ◽  
Solid State Structure ◽  
Π Stacking ◽  
Self Assembled

The phenoxy pendant isatins were observed to be highly potent inhibitors of acetylcholinesterase. In addition, the solid-state structure of a phenoxy pendant isatin showed an intriguing 1D-supramolecular self-assembled structure.

Spin Coating Mediated Morphology Modulation in Self Assembly of Peptides

Nanoscale ◽  
2021 ◽  
Author(s):  
Nandini Bhandaru ◽  
Gagandeep Kaur ◽  
Apurva Panjla ◽  
Sandeep Verma
Keyword(s):  
Self Assembly ◽  
Spin Coating ◽  
Material Science ◽  
Fundamental Importance ◽  
Self Assembled

Controlling the morphology and nanostructure of self-assembled peptide molecules is of fundamental importance to chemistry and material science due to their bioactivity in both in vivo and in vitro settings,...

Disulfide modified self-assembly of lipopeptides with arginine-rich periphery achieve excellent gene transfection efficiency at relatively low nitrogen to phosphorus ratios

2017 ◽  
Vol 5 (7) ◽  
pp. 1482-1497 ◽  
Author(s):  
Xiaobing Chen ◽  
Jun Yang ◽  
Hong Liang ◽  
Qian Jiang ◽  
Bowen Ke ◽  
...  
Keyword(s):  
Self Assembly ◽  
Disulfide Bonds ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Viral Envelope ◽  
Self Assembled ◽  
Low Nitrogen

Self-assembled lipopeptides, with viral envelope, capsid-inspired arginine-rich periphery and disulfide bonds, achieve excellent transfectionin vitroandin vivo.

scholarly journals Self-assembled ruthenium (II) metallacycles and metallacages with imidazole-based ligands and their in vitro anticancer activity

2019 ◽  
Vol 116 (10) ◽  
pp. 4090-4098 ◽  
Author(s):  
Yibo Zhao ◽  
Liqian Zhang ◽  
Xu Li ◽  
Yanhui Shi ◽  
Ruru Ding ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Self Assembly ◽  
Binding Modes ◽  
Hct 116 ◽  
Self Assembled ◽  
Half Sandwich ◽  
Trigonal Prismatic ◽  
Selection Of ◽  
Mcf 7

Six tetranuclear rectangular metallacycles were synthesized via the [2+2] coordination-driven self-assembly of imidazole-based ditopic donor 1,4-bis(imidazole-1-yl)benzene and 1,3-bis(imidazol-1-yl)benzene, with dinuclear half-sandwichp-cymene ruthenium(II) acceptors [Ru2(µ-η4-oxalato)(η6-p-cymene)2](SO3CF3)2, [Ru2(µ-η4-2,5-dioxido-1,4-benzoquinonato)(η6-p-cymene)2](SO3CF3)2and [Ru2(µ-η4-5,8-dioxido-1,4-naphtoquinonato)(η6-p-cymene)2](SO3CF3)2, respectively. Likewise, three hexanuclear trigonal prismatic metallacages were prepared via the [2+3] self-assembly of tritopic donor of 1,3,5-tri(1H-imidazol-1-yl)benzene with these ruthenium(II) acceptors respectively. Self-selection of the single symmetrical and stable metallacycle and cage was observed although there is the possibility of forming different conformational isomeric products due to different binding modes of these imidazole-based donors. The self-assembled macrocycles and cage containing the 5,8-dioxido-1,4-naphtoquinonato (donq) spacer exhibited good anticancer activity on all tested cancer cell lines (HCT-116, MDA-MB-231, MCF-7, HeLa, A549, and HepG-2), and showed decreased cytotoxicities in HBE and THLE-2 normal cells. The effect of Ru and imidazole moiety of these assemblies on the anticancer activity was discussed. The study of binding ability of these donq-based Ru assemblies with ctDNA indicated that the complex 9 with 180° linear 1 ligand has the highest bonding constantKbto ctDNA.

scholarly journals Self-assembled Nanoparticles of Polycationic b Rush and p Hotosensitizer for Synergistic Photothermal and Photodynamic Therapies Against Periodontitis

2021 ◽  
Author(s):  
Enyu Shi ◽  
Liya Bai ◽  
Lujia Mao ◽  
Hanping Wang ◽  
Xiaoying Yang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Photothermal Therapy ◽  
Chronic Inflammatory Disease ◽  
Bacterial Cells ◽  
Antibacterial Effects ◽  
Self Assembled ◽  
Bacterial Cell Membrane ◽  
Pass Through

Abstract Background: Periodontitis is a chronic inflammatory disease in oral cavity owing to bacterial infection. Photothermal therapy (PTT) and photodynamic therapy (PDT) have many advantages for antibacterial treatment. As an excellent photosensitizer, indocyanine green (ICG) shows prominent photothermal and photodynamic performances. However, it is difficult to pass through the negatively charged bacterial cell membrane, thus limits its antibacterial efficacy for periodontitis treatment.Results: In this work, we developed a nanosystem from self-assembly of ICG and polycationic brush for synergistic PTT and PDT against periodontitis. A star-shaped polycationic brush, poly(2-(dimethylamino)ethyl methacrylate) (sPDMA), was synthesized via atom transfer radical polymerization (ATRP) of DMA monomer from bromo-substituted β-cyclodextrin initiator (CD-Br). ICG was then self-assembled with sPDMA to form ICG-loaded sPDMA (sPDMA@ICG) nanoparticles (NPs), and the physicochemical properties of these NPs were characterized in detail. In vitro antibacterial effects of sPDMA@ICG NPs were evaluated in porphyromonas gingivalis (Pg), one of the recognized periodontitis pathogens, and in vivo anti-periodontitis effects of NPs were investigated in a rat periodontitis model. Benefiting from the unique brush-shaped architecture of sPDMA polycation, sPDMA@ICG NPs efficiently delivered ICG into the bacterial cells through promoting their adsorption and penetration abilities, and also exhibited effective antibacterial and anti-periodontitis actions via synergistic PTT and PDT both in vitro and in vivo.Conclusions: This work developed a promising nano-photosensitizer for synergistic PTT and PDT for antibacterial and periodontitis treatments in clinic.

Supramolecular Structure and Stability of the GNNQQNY β-Sheet Bilayer Filament: A Computational Study

2007 ◽  
Author(s):  
Jiyong Park ◽  
Byungnam Kahng ◽  
Wonmuk Hwang
Keyword(s):  
Self Assembly ◽  
Amyloid Fibrils ◽  
De Novo ◽  
Structural Information ◽  
Computational Study ◽  
Molecular Structures ◽  
Theoretical Approaches ◽  
Self Assembled ◽  
Β Sheet

Self-assembly of β-sheet forming peptides into filaments has drawn great interests in biomedical applications [1,2]; Hydrogels formed by filaments self-assembled from de novo designed peptides possess potential applications for cell culture scaffolds [3]. On the other hand, peptides derived from amyloidogenic proteins in neurodegenerative diseases such as Alzheimer’s and Parkinson’s also form similar β-sheet filaments in vitro. They share little sequence homology, yet filaments formed by these self-assembling peptides commonly have the cross-β structure, the key signature of the amyloid fibril. Detailed structural information of the self-assembled β-sheet filaments has been limited partly due to the difficulty in preparing ordered filament samples, and it has been only recently that solid-state nuclear magnetic resonance and x-ray techniques have revealed their molecular structure at the atomic level [4,5]. Although molecular structures of amyloid fibrils are becoming available, physical principles governing their self-assembly and the properties of the filaments are not well-understood, for which computational as well as theoretical approaches are desirable [6].

In vitro and in vivo polysaccharides assembly: ultrastructural and cytochemical study of growing plant cell wall components.

1978 ◽  
Vol 36 (2) ◽  
pp. 434-435
Author(s):  
D. Reis ◽  
B. Vian ◽  
J. C. Roland
Keyword(s):  
Cell Wall ◽  
Self Assembly ◽  
Plant Cell Wall ◽  
Higher Plants ◽  
Three Dimensional ◽  
Cytochemical Study ◽  
Wall Components

Wall morphogenesis in higher plants is a problem still open to controversy. Until now the possibility of a transmembrane control and the involvement of microtubules were mostly envisaged. Self-assembly processes have been observed in the case of walls of Chlamydomonas and bacteria. Spontaneous gelling interactions between xanthan and galactomannan from Ceratonia have been analyzed very recently. The present work provides indications that some processes of spontaneous aggregation could occur in higher plants during the formation and expansion of cell wall.Observations were performed on hypocotyl of mung bean (Phaseolus aureus) for which growth characteristics and wall composition have been previously defined.In situ, the walls of actively growing cells (primary walls) show an ordered three-dimensional organization (fig. 1). The wall is typically polylamellate with multifibrillar layers alternately transverse and longitudinal. Between these layers intermediate strata exist in which the orientation of microfibrils progressively rotates. Thus a progressive change in the morphogenetic activity occurs.

Nanoscale Self-Assembly Using Ion and Electron Beam Techniques: A Rapid Review

MRS Advances ◽  
2020 ◽  
Vol 5 (64) ◽  
pp. 3507-3520
Author(s):  
Chunhui Dai ◽  
Kriti Agarwal ◽  
Jeong-Hyun Cho
Keyword(s):  
Electron Beam ◽  
Self Assembly ◽  
Ion Beam ◽  
Three Dimensional ◽  
The Self ◽  
Stress Generation ◽  
Rapid Review ◽  
High Yield ◽  
3D Nanostructures ◽  
Self Assembled

AbstractNanoscale self-assembly, as a technique to transform two-dimensional (2D) planar patterns into three-dimensional (3D) nanoscale architectures, has achieved tremendous success in the past decade. However, an assembly process at nanoscale is easily affected by small unavoidable variations in sample conditions and reaction environment, resulting in a low yield. Recently, in-situ monitored self-assembly based on ion and electron irradiation has stood out as a promising candidate to overcome this limitation. The usage of ion and electron beam allows stress generation and real-time observation simultaneously, which significantly enhances the controllability of self-assembly. This enables the realization of various complex 3D nanostructures with a high yield. The additional dimension of the self-assembled 3D nanostructures opens the possibility to explore novel properties that cannot be demonstrated in 2D planar patterns. Here, we present a rapid review on the recent achievements and challenges in nanoscale self-assembly using electron and ion beam techniques, followed by a discussion of the novel optical properties achieved in the self-assembled 3D nanostructures.

Self-Assembly of a Chiral Cubic Three-Connected Net from the High Symmetry Molecules C60 and SnI4

2020 ◽  
Author(s):  
Daniel B. Straus ◽  
Robert J. Cava
Keyword(s):  
Organic Synthesis ◽  
Self Assembly ◽  
Van Der Waals ◽  
Van Der Waals Forces ◽  
High Symmetry ◽  
Molecular Chirality ◽  
Chiral Materials ◽  
Self Assembled ◽  
Chiral Centers

The design of new chiral materials usually requires stereoselective organic synthesis to create molecules with chiral centers. Less commonly, achiral molecules can self-assemble into chiral materials, despite the absence of intrinsic molecular chirality. Here, we demonstrate the assembly of high-symmetry molecules into a chiral van der Waals structure by synthesizing crystals of C<sub>60</sub>(SnI<sub>4</sub>)<sub>2</sub> from icosahedral buckminsterfullerene (C<sub>60</sub>) and tetrahedral SnI4 molecules through spontaneous self-assembly. The SnI<sub>4</sub> tetrahedra template the Sn atoms into a chiral cubic three-connected net of the SrSi<sub>2</sub> type that is held together by van der Waals forces. Our results represent the remarkable emergence of a self-assembled chiral material from two of the most highly symmetric molecules, demonstrating that almost any molecular, nanocrystalline, or engineered precursor can be considered when designing chiral assemblies.

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