Stereoselective organocatalysed reactions in deep eutectic solvents: highly tunable and biorenewable reaction media for sustainable organic synthesis

Different metal-free catalytic enantioselective reactions have been performed in high yields and enantioselectivity in natural, biorenewable and environmentally-friendly DESs. The recyclability of the chiral catalyst by a simple extraction protocol was also successfully accomplished.

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Metal-Free 1,2,3-Triazole Synthesis in Deep Eutectic Solvents

Synlett ◽

10.1055/s-0039-1690736 ◽

2019 ◽

Vol 31 (06) ◽

pp. 605-609

Author(s):

Filip Sebest ◽

Samuel Haselgrove ◽

Andrew J. P. White ◽

Silvia Díez-González

Keyword(s):

Deep Eutectic Solvent ◽

Environmentally Friendly ◽

Deep Eutectic Solvents ◽

Metal Free ◽

Chromatographic Techniques

The metal-free regioselective preparation of 1,5- and 1,4-disubstituted triazoles is reported through a cycloaddition–elimination sequence. Reactions were carried out in environmentally friendly deep eutectic solvent (DES) and pure products were isolated without the need for chromatographic techniques.

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facile, highly efficient and novel method for synthesis of 5-substituted 1H-tetrazoles catalysed by copper(I) chloride

Chemical Papers ◽

10.1515/chempap-2015-0124 ◽

2015 ◽

Vol 69 (9) ◽

Cited By ~ 7

Author(s):

İbrahim Esirden ◽

Erhan Başar ◽

Muharrem Kaya

Keyword(s):

Organic Synthesis ◽

Sodium Azide ◽

Cycloaddition Reaction ◽

Reaction Times ◽

Environmentally Friendly ◽

Wide Area ◽

Aryl Nitriles ◽

Novel Method ◽

High Yields ◽

Area Of Application

AbstractThe present study on tetrazole compounds, which have a wide area of application, proposes a new, simple and highly effective method. A series of 5-substituted 1H-tetrazoles were synthesised in DMF via the [3 + 2] cycloaddition reaction, in which different aryl nitriles with sodium azide were used and copper(I) chloride served as a catalyst. Short reaction times, high yields and simple procedures rendered this method attractive and useful for the organic synthesis of 5-substituted 1H-tetrazoles. A further advantage was the use of an environmentally friendly catalyst.

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Biocatalyzed Redox Processes Employing Green Reaction Media

Molecules ◽

10.3390/molecules25133016 ◽

2020 ◽

Vol 25 (13) ◽

pp. 3016

Author(s):

Carmen Aranda ◽

Gonzalo de Gonzalo

Keyword(s):

Environmentally Friendly ◽

Deep Eutectic Solvents ◽

Chemical Processes ◽

Redox Processes ◽

Aqueous Buffer ◽

Buffer Medium ◽

Neoteric Solvents ◽

Reaction Media

The application of biocatalysts to perform reductive/oxidative chemical processes has attracted great interest in recent years, due to their environmentally friendly conditions combined with high selectivities. In some circumstances, the aqueous buffer medium normally employed in biocatalytic procedures is not the best option to develop these processes, due to solubility and/or inhibition issues, requiring biocatalyzed redox procedures to circumvent these drawbacks, by developing novel green non-conventional media, including the use of biobased solvents, reactions conducted in neat conditions and the application of neoteric solvents such as deep eutectic solvents.

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BIOCATALYST FOR ENVIRONMENTALLY FRIENDLY PROCESSES OF ORGANIC SYNTHESIS AND BIODIESEL PRODUCTION

Tsitologiya ◽

10.31116/tsitol.2018.07.16 ◽

2018 ◽

Vol 60 (7) ◽

pp. 567-571

Author(s):

A. I. Sidorenko ◽

◽

A. V. Sklyarenko ◽

S. V. Yarotsky ◽

◽

...

Keyword(s):

Organic Synthesis ◽

Environmentally Friendly ◽

Biodiesel Production

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Heterogeneous System in Organic Synthesis: A Review

Mini-Reviews in Organic Chemistry ◽

10.2174/1570193x16666190830101802 ◽

2020 ◽

Vol 17 (6) ◽

pp. 740-753

Author(s):

Bishwajit Changmai ◽

Gunindra Pathak ◽

Jasha Momo H. Anal ◽

Lalthazuala Rokhum

Keyword(s):

Organic Synthesis ◽

Heterogeneous System ◽

Heterogeneous Catalysts ◽

Solid Phase Synthesis ◽

Solid Phase ◽

Environmentally Friendly ◽

Henry Reaction ◽

Phase Synthesis ◽

Recent Developments ◽

Recovery And Reuse

Due to its inherent advantages such as easy recovery and reuse of the catalysts/ reagents, and environmentally friendly nature, the heterogeneous system has gain popularity in the realm of organic synthesis. In recent years, several chemically or biologically potent molecules are achieved through heterogeneous synthesis strategies. By recalling some of the classical fundamentals of the heterogeneous system in important organic synthesis, this mini-review outlines the recent developments in the applications heterogeneous catalysts and reagents; particularly in the solid phase synthesis, esterification and transesterification reactions to produce biodiesel, and Henry reaction.

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Synthesis, Characterization and Applications of Dicationic Ionic Liquids in Organic Synthesis

Mini-Reviews in Organic Chemistry ◽

10.2174/1570193x16666190508091231 ◽

2020 ◽

Vol 17 (4) ◽

pp. 450-464

Author(s):

Mohammad Javaherian ◽

Seyyed Jafar Saghanezhad

Keyword(s):

Ionic Liquids ◽

Organic Synthesis ◽

Chemical Properties ◽

Physical And Chemical Properties ◽

Dicationic Ionic Liquids ◽

Physical And Chemical ◽

Reaction Media ◽

And Chemical Properties

Dicationic ionic liquids are an emerging group of Ionic Liquids (ILs) that are currently receiving much attention as green reaction media and catalysts. Because of a great number of possible combinations of cations and anions, the physical and chemical properties of dicationic ionic liquids are more tunable and broader than monocationic ILs. Therefore, their unique properties have made them the target of many applied and fundamental researches. Actually, dicationic ionic liquids are more effective and rather fascinating than traditional monocationic ILs. So, due to greater versatility and diversity, their applications in organic synthesis have been extensively grown. In this review, we have focused on the synthesis, characterization and applications of dicationic ionic liquids, especially, in organic synthesis.

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Environmentally Friendly Techniques and Their Comparison in the Extraction of Natural Antioxidants from Green Tea, Rosemary, Clove, and Oregano

Molecules ◽

10.3390/molecules26071869 ◽

2021 ◽

Vol 26 (7) ◽

pp. 1869

Author(s):

Mariel Calderón-Oliver ◽

Edith Ponce-Alquicira

Keyword(s):

Green Tea ◽

Electric Fields ◽

Antioxidant Activities ◽

Environmentally Friendly ◽

Natural Antioxidants ◽

Deep Eutectic Solvents ◽

Extraction Methods ◽

Extraction Techniques ◽

Health Trends ◽

Food Applications

Many current food and health trends demand the use of more ecological, sustainable, and environmentally friendly techniques for the extraction of bioactive compounds, including antioxidants. However, extraction yields and final antioxidant activities vary between sources and are highly influenced by the given extraction method and nature and ratio of the employed solvent, especially for total polyphenols, flavonoids, and anthocyanins, which are well recognized as natural antioxidants with food applications. This review focused on the most common extraction techniques and potential antioxidant activity in the food industry for various natural antioxidant sources, such as green tea, rosemary, clove, and oregano. Green extraction techniques have been proven to be far more efficient, environmentally friendly, and economical. In general, these techniques include the use of microwaves, ultrasound, high hydrostatic pressure, pulsed electric fields, enzymes, and deep eutectic solvents, among others. These extraction methods are described here, including their advantages, disadvantages, and applications.

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Cycloaddition of Thiourea- and Guanidine-Substituted Furans to Dienophiles: A Comparison of the Environmentally-Friendly Methods

Chemistry Proceedings ◽

10.3390/ecsoc-24-08380 ◽

2020 ◽

Vol 3 (1) ◽

pp. 57

Author(s):

Luka Barešić ◽

Davor Margetić ◽

Zoran Glasovac

Keyword(s):

High Pressure ◽

Functional Groups ◽

Organic Synthesis ◽

High Speed ◽

Environmentally Friendly ◽

Microwave Assisted ◽

Pressure Synthesis ◽

Ultrasound Assisted ◽

Substituted Furans ◽

Guanidine Moiety

The cycloaddition strategy was employed in order to obtain a 7-oxanorbornene framework substituted with a guanidine moiety or its precursor functional groups: protected amine or thiourea. In order to optimize the conditions for the cycloaddition, several environmentally-friendly methods—microwave assisted organic synthesis, high pressure synthesis, high speed vibrational milling, and ultrasound assisted synthesis—were employed. The outcomes of the cycloaddition reactions were interpreted in terms of endo/exo selectivity, the conversion of the reactants to the product, and the isolated yields. In general, our results indicated the HP and HSVM approaches as the methods of choice to give good yields and conversions.

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