Signalling to the nucleus under the control of light and small molecules

2016 ◽  
Vol 12 (2) ◽  
pp. 345-349 ◽  
Author(s):  
Samuel Juillot ◽  
Hannes M. Beyer ◽  
Josef Madl ◽  
Wilfried Weber ◽  
Matias D. Zurbriggen ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Small Molecules ◽  
Regulatory Mechanism ◽  
Cell Signalling ◽  
Signalling Pathway ◽  
Temporal Control ◽  
Signalling Molecules ◽  
Entire Cell ◽  
Spatio Temporal ◽  
Cell Signalling Pathway

One major regulatory mechanism in cell signalling is the spatio-temporal control of the localization of signalling molecules. We synthetically designed an entire cell signalling pathway, which allows controlling the transport of signalling molecules from the plasma membrane to the nucleus, by using light and small molecules.

Caveolin-1, galectin-3 and lipid raft domains in cancer cell signalling

2015 ◽  
Vol 57 ◽  
pp. 189-201 ◽  
Author(s):  
Jay Shankar ◽  
Cecile Boscher ◽  
Ivan R. Nabi
Keyword(s):  
Plasma Membrane ◽  
Lipid Rafts ◽  
Cancer Cell ◽  
Cellular Response ◽  
Spatial Organization ◽  
Essential Feature ◽  
Cell Signalling ◽  
Coated Pits ◽  
Signalling Molecules ◽  
Raft Domains

Spatial organization of the plasma membrane is an essential feature of the cellular response to external stimuli. Receptor organization at the cell surface mediates transmission of extracellular stimuli to intracellular signalling molecules and effectors that impact various cellular processes including cell differentiation, metabolism, growth, migration and apoptosis. Membrane domains include morphologically distinct plasma membrane invaginations such as clathrin-coated pits and caveolae, but also less well-defined domains such as lipid rafts and the galectin lattice. In the present chapter, we will discuss interaction between caveolae, lipid rafts and the galectin lattice in the control of cancer cell signalling.

Cell signalling pathway involved in PACAP-induced AR4-2J cell proliferation

1995 ◽  
Vol 7 (3) ◽  
pp. 195-205 ◽  
Author(s):  
Jean Morisset ◽  
Nadine Douziech ◽  
Grazyna Rydzewska ◽  
Louis Buscail ◽  
Nathalie Rivard
Keyword(s):  
Cell Proliferation ◽  
Cell Signalling ◽  
Signalling Pathway ◽  
Cell Signalling Pathway

scholarly journals A leucine-rich diet modulates the mTOR cell signalling pathway in the gastrocnemius muscle under different Walker-256 tumour growth conditions

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Bread Cruz ◽  
André Oliveira ◽  
Gislaine Ventrucci ◽  
Maria Cristina Cintra Gomes-Marcondes
Keyword(s):  
Tumour Growth ◽  
Gastrocnemius Muscle ◽  
Cell Signalling ◽  
Growth Conditions ◽  
Signalling Pathway ◽  
Walker 256 Tumour ◽  
Walker 256 ◽  
Cell Signalling Pathway

scholarly journals Role of cell polarity dynamics and motility in pattern formation due to contact-dependent signalling

2021 ◽  
Vol 18 (175) ◽  
pp. 20200825
Author(s):  
Supriya Bajpai ◽  
Ranganathan Prabhakar ◽  
Raghunath Chelakkot ◽  
Mandar M. Inamdar
Keyword(s):  
Cell Motility ◽  
Cell Polarity ◽  
Collective Motion ◽  
Cell Signalling ◽  
Cell Polarization ◽  
Physical Contact ◽  
Signalling Molecules ◽  
Tightly Coupled ◽  
Spatio Temporal ◽  
Cell Cell

A key challenge in biology is to understand how spatio-temporal patterns and structures arise during the development of an organism. An initial aggregate of spatially uniform cells develops and forms the differentiated structures of a fully developed organism. On the one hand, contact-dependent cell–cell signalling is responsible for generating a large number of complex, self-organized, spatial patterns in the distribution of the signalling molecules. On the other hand, the motility of cells coupled with their polarity can independently lead to collective motion patterns that depend on mechanical parameters influencing tissue deformation, such as cellular elasticity, cell–cell adhesion and active forces generated by actin and myosin dynamics. Although modelling efforts have, thus far, treated cell motility and cell–cell signalling separately, experiments in recent years suggest that these processes could be tightly coupled. Hence, in this paper, we study how the dynamics of cell polarity and migration influence the spatiotemporal patterning of signalling molecules. Such signalling interactions can occur only between cells that are in physical contact, either directly at the junctions of adjacent cells or through cellular protrusional contacts. We present a vertex model which accounts for contact-dependent signalling between adjacent cells and between non-adjacent neighbours through long protrusional contacts that occur along the orientation of cell polarization. We observe a rich variety of spatiotemporal patterns of signalling molecules that is influenced by polarity dynamics of the cells, relative strengths of adjacent and non-adjacent signalling interactions, range of polarized interaction, signalling activation threshold, relative time scales of signalling and polarity orientation, and cell motility. Though our results are developed in the context of Delta–Notch signalling, they are sufficiently general and can be extended to other contact dependent morpho-mechanical dynamics.

Targeting the B-cell signalling pathway in CLL and MCL

2013 ◽  
Vol 14 (9) ◽  
pp. e343 ◽  
Author(s):  
Sharan Prakash Sharma
Keyword(s):  
B Cell ◽  
Cell Signalling ◽  
Signalling Pathway ◽  
Cell Signalling Pathway

scholarly journals Message from the cell's powerhouse: Mitochondrial signalling and redox therapeutics

2005 ◽  
Vol 27 (3) ◽  
pp. 9-14
Author(s):  
Aimee L. Landar ◽  
Jaroslaw W. Zmijewski ◽  
Joo-Yeun Oh ◽  
Victor M. Darley-Usmar
Keyword(s):  
Nitric Oxide ◽  
Small Molecules ◽  
Reactive Nitrogen Species ◽  
Cell Signalling ◽  
Mitochondrial Respiratory Chain ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Signalling Molecules ◽  
Ability To Act ◽  
Lines Of Evidence

Some of the earliest studies in bioenergetics described a ‘leak’ of electrons from the mitochondrial respiratory chain to oxygen, with the resulting formation of the simple one-electron product, superoxide. Several lines of evidence led to the idea that this process is pathological. For example, formation of superoxide, and its dismutation product hydrogen peroxide, from the mitochondrion was enhanced by mitochondrial poisons and hyperoxia. Since these early beginnings, studies in the redox cell signalling field have shown that these same reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as nitric oxide (NO), serve as signalling molecules in both physiological and pathological situations. These small molecules can act through several mechanisms, including the ability to act as reversible agonists for receptors.

Discovery via Proteomics of a Novel Cell Signalling Pathway in Plants Involving Extracellular ATP

2007 ◽  
pp. 71-86
Author(s):  
Stephen Chivasa ◽  
William J. Simon ◽  
John M. Hamilton ◽  
Keith Lindsey ◽  
Antoni R. Slabas
Keyword(s):  
Cell Signalling ◽  
Extracellular Atp ◽  
Signalling Pathway ◽  
Cell Signalling Pathway
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