Synthesis of an acid-labile polymeric prodrug DOX-acetal-PEG-acetal-DOX with high drug loading content for pH-triggered intracellular drug release

2015 ◽  
Vol 6 (26) ◽  
pp. 4809-4818 ◽  
Author(s):  
Hairong Wang ◽  
Jinlin He ◽  
Dongling Cao ◽  
Mingzu Zhang ◽  
Fei Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Click Reaction ◽  
Drug Loading ◽  
High Drug ◽  
Polymeric Prodrug ◽  
Acid Labile ◽  
High Drug Loading

PEGylated doxorubicin (DOX) prodrugs with high drug loading content have been prepared via a combination of CuAAC “click” reaction and ammonolysis reaction, which can be used for pH-triggered delivery of doxorubicin.

scholarly journals J‐Aggregate‐Based FRET Monitoring of Drug Release from Polymer Nanoparticles with High Drug Loading

2020 ◽  
Vol 59 (45) ◽  
pp. 20065-20074 ◽  
Author(s):  
Yun Liu ◽  
Guangze Yang ◽  
Song Jin ◽  
Run Zhang ◽  
Peng Chen ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Loading ◽  
Polymer Nanoparticles ◽  
High Drug ◽  
High Drug Loading

Construction of High Drug Loading and Enzymatic Degradable Multilayer Films for Self-Defense Drug Release and Long-Term Biofilm Inhibition

2017 ◽  
Vol 19 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Bailiang Wang ◽  
Huihua Liu ◽  
Lin Sun ◽  
Yingying Jin ◽  
Xiaoxu Ding ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Loading ◽  
Multilayer Films ◽  
Biofilm Inhibition ◽  
High Drug ◽  
Self Defense ◽  
High Drug Loading

scholarly journals Zirconium-Porphyrin PCN-222: pH-responsive Controlled Anticancer Drug Oridonin

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Xin Leng ◽  
Hongliang Huang ◽  
Wenping Wang ◽  
Na Sai ◽  
Longtai You ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Hepg2 Cells ◽  
Drug Loading ◽  
Annexin V ◽  
Controlled Drug Release ◽  
Dapi Staining ◽  
High Drug ◽  
High Drug Loading

Drug delivery carriers with a high drug loading capacity and biocompatibility, especially for controlled drug release, are urgently needed due to the side effects and frequent dose in the traditional therapeutic method. Guided by nanomaterials, we have successfully synthesized zirconium-based metal−organic frameworks, Zr-TCPP (TCPP: tetrakis (4-carboxyphenyl) porphyrin), namely, PCN-222, which is synthesized by solvothermal method. And it has been designed as a drug delivery system (DDS) with a high drug loading of 38.77 wt%. In our work, PCN-222 has achieved pH-sensitive drug release and showed comprehensive SEM, TEM, PXRD, DSC, FTIR, and N2 adsorption-desorption. The low cytotoxicity and good biocompatibility of PCN-222 were certificated by the in vitro results from an MTT assay, DAPI staining, and Annexin V/PI double-staining even cultivated L02 cells and HepG2 cells for 48h. Furthermore, Oridonin, a commonly used cancer chemotherapy drug, is adsorbed into PCN-222 via the solvent diffusion technique. Based on an analysis of the Oridonin release profile, results suggest that it can last for more than 7 days in vitro. And cumulative release rate of Ori at the 7 d was about 86.29% and 63.23% in PBS (pH 5.5 and pH 7.2, respectively) at 37°C. HepG2 cells were chosen to research the cytotoxicity of PCN-222@Ori and free Oridonin. The results demonstrated that the PCN-222@Ori nanocarrier shows higher cytotoxicity in HepG2 cells compared to Oridonin.

Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro

2019 ◽  
Vol 7 (7) ◽  
pp. 1050-1055 ◽  
Author(s):  
Liangcan He ◽  
Kanglei Pang ◽  
Wenwen Liu ◽  
Yue Tian ◽  
Lin Chang ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Treatment ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Core Shell ◽  
Treatment Efficiency ◽  
Zeolitic Imidazolate Framework ◽  
High Drug ◽  
High Drug Loading

Core–shell Au@zeolitic-imidazolate-framework nanocarriers with high drug-loading, controlled drug release properties, and high cancer treatment efficiency.

Fabrication of rod-like nanocapsules based on polylactide and 3,4-dihydroxyphenylalanine for a drug delivery system

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103414-103420 ◽  
Author(s):  
Dongjian Shi ◽  
Lei Zhang ◽  
Jiali Shen ◽  
Xiaojie Li ◽  
Mingqing Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
High Drug ◽  
Buffer Solutions ◽  
System P ◽  
Ph Buffer ◽  
High Drug Loading

Rod-like nanocapsules were facilely fabricated based on a bio-based polymer via DOPA adhesion. The nanocapsules showed high drug-loading efficacies and controlled drug release depending on different pH buffer solutions.

Dimeric camptothecin-loaded mPEG-PCL nanoparticles with high drug loading and reduction-responsive drug release

2019 ◽  
Vol 298 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Yanwei Chi ◽  
Zhiying Wang ◽  
Jie Wang ◽  
Wenpei Dong ◽  
Pengyang Xin ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Loading ◽  
High Drug ◽  
High Drug Loading

Preparation and Characterization of Hydroxycamptothecin-Loaded Poly(D,L-lactic acid) Nanoparticles with High Drug Loading Capacity

2012 ◽  
Vol 531 ◽  
pp. 503-506
Author(s):  
Zhen Qing Hou ◽  
Shui Fan Zhou ◽  
Fei Cui ◽  
Yi Xiao Hang ◽  
Yun Feng Yi
Keyword(s):  
Drug Release ◽  
Orthogonal Design ◽  
Drug Loading ◽  
Influential Factors ◽  
Prolonged Release ◽  
Loading Capacity ◽  
Sustained Drug Release ◽  
High Drug ◽  
High Drug Loading

Hydroxycamptothecin (HCPT) loaded PLA nanoparticles were prepared by a facile dialysis method. Three main influential factors, PLA concentration, ratio of HCPT to PLA (wt/wt), dialysis bags with different molecule weight cutoff, were evaluated using an orthogonal design, gave the nanoparticles with an average diameter of approximately 226.8 nm and fine drug loading content (5.16%, w/w). The in vitro drug release studies exhibited a slow and prolonged release profile over 30 days. It is concluded that the new method to prepare HCPT-PLA nanoparticles resulted in improved formulation characteristics including small size, high drug loading capacity, and long sustained drug release.

Polytyrosine nanoparticles enable ultra-high loading of doxorubicin and rapid enzyme-responsive drug release

2018 ◽  
Vol 6 (6) ◽  
pp. 1526-1534 ◽  
Author(s):  
Xiaolei Gu ◽  
Min Qiu ◽  
Huanli Sun ◽  
Jian Zhang ◽  
Liang Cheng ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Loading ◽  
High Loading ◽  
Anticancer Effect ◽  
High Drug ◽  
Triggered Drug Release ◽  
High Drug Loading

PTN-DOX with a high drug loading (DLC: 63.1 wt%) and triggered drug release achieves a superior anticancer effect to liposomal DOX.

A novel composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan: preparation and application in drug delivery

2017 ◽  
Vol 5 (21) ◽  
pp. 3898-3906 ◽  
Author(s):  
Yong-Gang Zhang ◽  
Ying-Jie Zhu ◽  
Feng Chen ◽  
Tuan-Wei Sun
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Composite Scaffold ◽  
Drug Loading ◽  
Loading Capacity ◽  
Sustained Drug Release ◽  
High Drug ◽  
High Drug Loading

The composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan with high drug loading capacity and sustained drug release properties has been successfully prepared.

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