Preparation and Characterization of Hydroxycamptothecin-Loaded Poly(D,L-lactic acid) Nanoparticles with High Drug Loading Capacity
Keyword(s):
Hydroxycamptothecin (HCPT) loaded PLA nanoparticles were prepared by a facile dialysis method. Three main influential factors, PLA concentration, ratio of HCPT to PLA (wt/wt), dialysis bags with different molecule weight cutoff, were evaluated using an orthogonal design, gave the nanoparticles with an average diameter of approximately 226.8 nm and fine drug loading content (5.16%, w/w). The in vitro drug release studies exhibited a slow and prolonged release profile over 30 days. It is concluded that the new method to prepare HCPT-PLA nanoparticles resulted in improved formulation characteristics including small size, high drug loading capacity, and long sustained drug release.
2017 ◽
Vol 5
(21)
◽
pp. 3898-3906
◽
Keyword(s):
Keyword(s):
2018 ◽
Vol 2018
◽
pp. 1-12
◽
Keyword(s):
2019 ◽
Vol 7
(7)
◽
pp. 1050-1055
◽
Keyword(s):
2021 ◽
Vol 316
◽
pp. 110950
Keyword(s):
2019 ◽
Vol 7
(28)
◽
pp. 4402-4412
◽
2014 ◽
Vol 174
◽
pp. 161-170
◽
Keyword(s):
Keyword(s):