Zirconium-Porphyrin PCN-222: pH-responsive Controlled Anticancer Drug Oridonin

Drug delivery carriers with a high drug loading capacity and biocompatibility, especially for controlled drug release, are urgently needed due to the side effects and frequent dose in the traditional therapeutic method. Guided by nanomaterials, we have successfully synthesized zirconium-based metal−organic frameworks, Zr-TCPP (TCPP: tetrakis (4-carboxyphenyl) porphyrin), namely, PCN-222, which is synthesized by solvothermal method. And it has been designed as a drug delivery system (DDS) with a high drug loading of 38.77 wt%. In our work, PCN-222 has achieved pH-sensitive drug release and showed comprehensive SEM, TEM, PXRD, DSC, FTIR, and N2 adsorption-desorption. The low cytotoxicity and good biocompatibility of PCN-222 were certificated by the in vitro results from an MTT assay, DAPI staining, and Annexin V/PI double-staining even cultivated L02 cells and HepG2 cells for 48h. Furthermore, Oridonin, a commonly used cancer chemotherapy drug, is adsorbed into PCN-222 via the solvent diffusion technique. Based on an analysis of the Oridonin release profile, results suggest that it can last for more than 7 days in vitro. And cumulative release rate of Ori at the 7 d was about 86.29% and 63.23% in PBS (pH 5.5 and pH 7.2, respectively) at 37°C. HepG2 cells were chosen to research the cytotoxicity of PCN-222@Ori and free Oridonin. The results demonstrated that the PCN-222@Ori nanocarrier shows higher cytotoxicity in HepG2 cells compared to Oridonin.

Download Full-text

Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro

Journal of Materials Chemistry B ◽

10.1039/c8tb03318h ◽

2019 ◽

Vol 7 (7) ◽

pp. 1050-1055 ◽

Cited By ~ 5

Author(s):

Liangcan He ◽

Kanglei Pang ◽

Wenwen Liu ◽

Yue Tian ◽

Lin Chang ◽

...

Keyword(s):

Drug Release ◽

Cancer Treatment ◽

Drug Loading ◽

Controlled Drug Release ◽

Core Shell ◽

Treatment Efficiency ◽

Zeolitic Imidazolate Framework ◽

High Drug ◽

High Drug Loading

Core–shell Au@zeolitic-imidazolate-framework nanocarriers with high drug-loading, controlled drug release properties, and high cancer treatment efficiency.

Download Full-text

Fabrication of rod-like nanocapsules based on polylactide and 3,4-dihydroxyphenylalanine for a drug delivery system

RSC Advances ◽

10.1039/c5ra21549h ◽

2015 ◽

Vol 5 (125) ◽

pp. 103414-103420 ◽

Cited By ~ 8

Author(s):

Dongjian Shi ◽

Lei Zhang ◽

Jiali Shen ◽

Xiaojie Li ◽

Mingqing Chen ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Drug Loading ◽

Controlled Drug Release ◽

High Drug ◽

Buffer Solutions ◽

System P ◽

Ph Buffer ◽

High Drug Loading

Rod-like nanocapsules were facilely fabricated based on a bio-based polymer via DOPA adhesion. The nanocapsules showed high drug-loading efficacies and controlled drug release depending on different pH buffer solutions.

Download Full-text

Pressure controlled drug release in a Zr-cluster-based MOF

Journal of Materials Chemistry B ◽

10.1039/c6tb01756h ◽

2016 ◽

Vol 4 (39) ◽

pp. 6398-6401 ◽

Cited By ~ 46

Author(s):

Ke Jiang ◽

Ling Zhang ◽

Quan Hu ◽

Dian Zhao ◽

Tifeng Xia ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Loading ◽

Controlled Drug Release ◽

Loading Capacity ◽

High Drug ◽

Pressure Controlled ◽

High Drug Loading

A Zr-cluster-based MOF ZJU-800 was synthesized with high drug loading capacity for controllable drug delivery from 2 days to 8 days.

Download Full-text

Preparation and Characterization of Hydroxycamptothecin-Loaded Poly(D,L-lactic acid) Nanoparticles with High Drug Loading Capacity

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.531.503 ◽

2012 ◽

Vol 531 ◽

pp. 503-506

Author(s):

Zhen Qing Hou ◽

Shui Fan Zhou ◽

Fei Cui ◽

Yi Xiao Hang ◽

Yun Feng Yi

Keyword(s):

Drug Release ◽

Orthogonal Design ◽

Drug Loading ◽

Influential Factors ◽

Prolonged Release ◽

Loading Capacity ◽

Sustained Drug Release ◽

High Drug ◽

High Drug Loading

Hydroxycamptothecin (HCPT) loaded PLA nanoparticles were prepared by a facile dialysis method. Three main influential factors, PLA concentration, ratio of HCPT to PLA (wt/wt), dialysis bags with different molecule weight cutoff, were evaluated using an orthogonal design, gave the nanoparticles with an average diameter of approximately 226.8 nm and fine drug loading content (5.16%, w/w). The in vitro drug release studies exhibited a slow and prolonged release profile over 30 days. It is concluded that the new method to prepare HCPT-PLA nanoparticles resulted in improved formulation characteristics including small size, high drug loading capacity, and long sustained drug release.

Download Full-text

In vitro breast cancer targeting using Trastuzumab-conjugated mesoporous silica nanoparticles: Towards the new strategy for decreasing size and high drug loading capacity for drug delivery purposes in MSN synthesis

Microporous and Mesoporous Materials ◽

10.1016/j.micromeso.2021.110950 ◽

2021 ◽

Vol 316 ◽

pp. 110950

Author(s):

Mohammad Mozafarinia ◽

Sadegh Karimi ◽

Maryam Farrokhnia ◽

Javid Esfandiari

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Mesoporous Silica Nanoparticles ◽

Drug Loading ◽

Cancer Targeting ◽

Loading Capacity ◽

High Drug ◽

New Strategy ◽

High Drug Loading

Download Full-text

A novel composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan: preparation and application in drug delivery

Journal of Materials Chemistry B ◽

10.1039/c6tb02576e ◽

2017 ◽

Vol 5 (21) ◽

pp. 3898-3906 ◽

Cited By ~ 22

Author(s):

Yong-Gang Zhang ◽

Ying-Jie Zhu ◽

Feng Chen ◽

Tuan-Wei Sun

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Composite Scaffold ◽

Drug Loading ◽

Loading Capacity ◽

Sustained Drug Release ◽

High Drug ◽

High Drug Loading

The composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan with high drug loading capacity and sustained drug release properties has been successfully prepared.

Download Full-text

High-drug-loading capacity of redox-activated biodegradable nanoplatform for active targeted delivery of chemotherapeutic drugs

Regenerative Biomaterials ◽

10.1093/rb/rbaa027 ◽

2020 ◽

Vol 7 (4) ◽

pp. 359-369

Author(s):

Hai Zhang ◽

Jianqin Yan ◽

Heng Mei ◽

Shengsheng Cai ◽

Sai Li ◽

...

Keyword(s):

Drug Release ◽

Polymeric Micelles ◽

Drug Loading ◽

Active Targeting ◽

Control Group ◽

Loading Capacity ◽

Disulfide Linkage ◽

High Drug ◽

High Drug Loading

Abstract Challenges associated with low-drug-loading capacity, lack of active targeting of tumor cells and unspecific drug release of nanocarriers synchronously plague the success of cancer therapy. Herein, we constructed active-targeting, redox-activated polymeric micelles (HPGssML) self-assembled aptamer-decorated, amphiphilic biodegradable poly (benzyl malolactonate-co-ε-caprolactone) copolymer with disulfide linkage and π-conjugated moieties. HPGssML with a homogenous spherical shape and nanosized diameter (∼150 nm) formed a low critical micellar concentration (10−3 mg/mL), suggesting good stability of polymeric micelles. The anticancer drug, doxorubicin (DOX), can be efficiently loaded into the core of micelles with high-drug-loading content via strong π–π interaction, which was verified by a decrease in fluorescence intensity and redshift in UV adsorption of DOX in micelles. The redox sensitivity of polymeric micelles was confirmed by size change and in vitro drug release in a reducing environment. Confocal microscopy and flow cytometry assay demonstrated that conjugating aptamers could enhance specific uptake of HPGssML by cancer cells. An in vitro cytotoxicity study showed that the half-maximal inhibitory concentration (IC50) of DOX-loaded HPGssML was two times lower than that of the control group, demonstrating improved antitumor efficacy. Therefore, the multifunctional biodegradable polymeric micelles can be exploited as a desirable drug carrier for effective cancer treatment.

Download Full-text

Nanoscale covalent organic frameworks as smart carriers for drug delivery

Chemical Communications ◽

10.1039/c6cc00853d ◽

2016 ◽

Vol 52 (22) ◽

pp. 4128-4131 ◽

Cited By ~ 189

Author(s):

Linyi Bai ◽

Soo Zeng Fiona Phua ◽

Wei Qi Lim ◽

Avijit Jana ◽

Zhong Luo ◽

...

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Drug Loading ◽

Drug Carriers ◽

Loading Capacity ◽

Covalent Organic Frameworks ◽

High Drug ◽

Good Biocompatibility ◽

High Drug Loading

Two nanoscale covalent organic frameworks as drug carriers with good biocompatibility were developed, showing high drug loading capacity and sustained release in vitro.

Download Full-text