Myrtle berry seed aqueous extract inhibits human neutrophil myeloperoxidase in vitro and attenuates acetic acid-induced ulcerative colitis in rats

We aimed in the present study to investigate the protective effect of a myrtle (Myrtus communisL.) berry seed aqueous extract (MBSAE) on acetic acid (AA)-induced colitis in rats as well as the mechanism implicated in this coli-protection.

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SYNTHESIS, IN-VITRO ANTIOXIDANT, ANTIBACTERIAL ACTIVITIES OF NOVEL SULFONAMIDES FROM 5-AMINOSALICYLIC ACID: PROTECTIVE EFFECT OF SELECTED SULFONAMIDES ON ACETIC ACID INDUCED ULCERATIVE COLITIS IN RATS

International Research Journal of Pharmacy ◽

10.7897/2230-8407.0912302 ◽

2019 ◽

Vol 9 (12) ◽

pp. 105-113

Author(s):

Madhavi Kuchana ◽

Bindu Sree Nadakuditi

Keyword(s):

Ulcerative Colitis ◽

Acetic Acid ◽

Protective Effect ◽

Antibacterial Activities ◽

Aminosalicylic Acid

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Protective Effect of A2B Receptor Antagonist (TRP 1) on Acetic Acid Induced Ulcerative Colitis in Rats: in vitro, in vivo and in silico Methods

Indian Journal of Pharmaceutical Education and Research ◽

10.5530/ijper.52.1.12 ◽

2018 ◽

Vol 52 (1) ◽

pp. 101-109 ◽

Cited By ~ 1

Author(s):

Praveen Kumar Pasala ◽

Ramesh Alluri ◽

Sri Chandana Mavulati ◽

Raghu Prasad Mailavaram ◽

Khasim Shaik ◽

...

Keyword(s):

Ulcerative Colitis ◽

Acetic Acid ◽

Protective Effect ◽

Receptor Antagonist ◽

In Silico ◽

A2b Receptor ◽

In Silico Methods

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Eluxadoline Loaded Solid Lipid Nanoparticles for Improved Colon Targeting in Rat Model of Ulcerative Colitis

Pharmaceuticals ◽

10.3390/ph13090255 ◽

2020 ◽

Vol 13 (9) ◽

pp. 255

Author(s):

Md. Khalid Anwer ◽

Mohammed Muqtader Ahmed ◽

Mohammed F. Aldawsari ◽

Saad Alshahrani ◽

Farhat Fatima ◽

...

Keyword(s):

Ulcerative Colitis ◽

Acetic Acid ◽

Zeta Potential ◽

Solid Lipid Nanoparticles ◽

In Vitro Release ◽

Lipid Nanoparticles ◽

Stability Studies ◽

Solid Lipid ◽

Vitro Release

The aim of the current study was to evaluate the therapeutics potential of eluxadoline (ELX) loaded solid lipid nanoparticles (SLNs) in ulcerative colitis. ELX loaded SLNs were prepared using three different lipids according to the solvent emulsification technique. The optimization of prepared SLNs (F1-F3) were carried out based on size, PDI, zeta potential, percent drug entrapment (%EE), and loading (%DL). The lipid (stearic acid) based SLNs (F2) was optimized with particle size (266.0 ± 6.4 nm), PDI (0.217 ± 0.04), zeta potential (31.2 ± 5.19 mV), EE (65.0 ± 4.8%), and DL (4.60 ± 0.8%). The optimized SLNs (F2) was further evaluated by DSC, FTIR, SEM, in vitro release, and stability studies, which confirmed the successful encapsulation of ELX in SLNs. The efficacy of optimized SLNs (F2) in comparison to the pure ELX drug was assessed in acetic acid induced colitis rat models. It was observed that the delivery of ELX by SLNs alleviated the induced acetic acid colitis significantly. Thus, ELX loaded SLNs delivery to the colon has a significant potential to be developed for the treatment of ulcerative colitis.

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ANTI-INFLAMMATORY ACTIVITY OF CURCUMIN AND CAPSAICIN AUGMENTED IN COMBINATION

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i6.18635 ◽

2017 ◽

Vol 9 (6) ◽

pp. 145

Author(s):

Thriveni Vasanth Kumar ◽

Manjunatha H. ◽

Rajesh Kp

Keyword(s):

Acetic Acid ◽

Protective Effect ◽

Vascular Permeability ◽

Diclofenac Sodium ◽

Significant Inhibition ◽

Inflammatory Activity ◽

Anti Inflammatory ◽

The Individual

Objective: Dietary curcumin and capsaicin are well known for their health beneficial potencies. The current study was done to assess the anti-inflammatory activity of curcumin, capsaicin and their combination by employing in vitro and in vivo models.Methods: We investigated the protective effect of curcumin, capsaicin and their combination using in vitro heat induced human red blood cell (HRBC) membrane stabilisation, in vivo 3% agar induced leukocyte mobilisation and acetic acid induced vascular permeability assay.Results: Curcumin, capsaicin and their combination exhibited concentration dependent protective effect against heat-induced HRBC membrane destabilisation, while combined curcumin and capsaicin restored 87.0±0.64 % membrane stability and it is found to be better than curcumin, capsaicin and diclofenac sodium (75.0±0.25. 72±0.9 and 80.0±0.31 %) protective effect. In agar suspension induced leukocyte mobilization assay, the combined curcumin and capsaicin had shown 39.5±1.58 % of inhibition compared to individual curcumin and capsaicin, which showed moderate inhibition of 16.0±3.14 and 21.6±2.17 % respectively. Besides, the combined curcumin and capsaicin had shown highly significant inhibition of acetic acid-induced vascular permeability in rats (62.0±3.14 %), whereas individual curcumin and capsaicin showed moderate inhibition of vascular permeability with 36.0±2.41 and 43.0±1.92 % respectively.Conclusion: This study demonstrates the significant anti-inflammatory property of combined curcumin and capsaicin at half of the individual concentration of curcumin and capsaicin.

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