scholarly journals Proteomic analysis of hippocampus in mice following long-term exposure to low levels of copper

2016 ◽  
Vol 5 (4) ◽  
pp. 1130-1139 ◽  
Author(s):  
Qian Sun ◽  
Ming Ying ◽  
Quan Ma ◽  
Zhijun Huang ◽  
Liangyu Zou ◽  
...  

Recent studies suggest that copper exposure, even at very low levels, can produce significant toxic effects on the brains of mice.




2020 ◽  
Vol 81 (4) ◽  
pp. 198-203
Author(s):  
Lisa M. Duizer ◽  
Heather H. Keller

Prevalence of micronutrient malnutrition is high in individuals living in long-term care (LTC) homes with many individuals consuming low levels of vitamins B6, D, and E; folate; calcium; magnesium; and zinc. The focus of this research was to identify strategies and challenges encountered during development of micronutrient-dense menus for use in Ontario LTC homes and to examine costs associated with development of a menu with acceptable micronutrients. Semi-structured open-ended interviews were conducted with 13 menu planners (7 dietitians, 6 nutrition managers) in diverse LTC homes in Ontario. Data were thematically analyzed. A 7-day hypothetical menu meeting all nutrient requirements was developed and costed. Analysis of the interview data showed that menus are planned according to the Canada’s Food Guide (2007) and focus placed on Dietary Reference Intakes of protein, fibre, calcium, and sodium. Little focus is placed on micronutrients. Flexibility in foods offered was important to accommodate the small volume of food consumed. Resident preferences were balanced against nutritional requirements. Challenges included planning for diverse populations, managing portion sizes, and balancing the budget. A hypothetical menu planned to contain adequate levels of all micronutrients is 49% higher in food costs than the amount currently provided to Ontario LTC homes.



2008 ◽  
Vol 53 (22) ◽  
pp. 3530-3537 ◽  
Author(s):  
Fei Gao ◽  
YiJun Zhou ◽  
LingYun Huang ◽  
DaCheng He ◽  
GenFa Zhang


2015 ◽  
pp. 00-00 ◽  
Author(s):  
Reema Bansal ◽  
Laura J. Liermann ◽  
Bruce A. Stanley ◽  
Susan L. Brantley ◽  
Ming Tien


Author(s):  
Paweł Bukowski ◽  
Filip Novokmet

AbstractWe construct the first consistent series on the long-term distribution of income in Poland by combining tax, household survey and national accounts data. We document a U-shaped evolution of inequalities from the end of the nineteenth century until today: (1) inequality was high before WWII; (2) abruptly fell after the introduction of communism in 1947 and stagnated at low levels during the whole communist period; (3) experienced a sharp rise with the return to capitalism in 1989. We find that official survey-based measures strongly under-estimate the rise in inequality since 1989. Our results highlight the prominent role of capital income in driving the U-shaped evolution of top income shares. The unique inequality history of Poland speaks to the central role of institutions and policies in shaping inequality in the long run.



1994 ◽  
Vol 165 (S26) ◽  
pp. 9-15 ◽  
Author(s):  
Martin B. Keller

The realisation that major depression is often both chronic and recurrent has slowly begun to change the way that depression is diagnosed and treated. In particular, the need for continuation and maintenance treatment is an issue that now deserves increased attention, especially with the availability of new classes of antidepressant treatments, which have excellent efficacy and more favourable side-effect profiles. Although the serious consequences of depressive disorders clearly indicate the need for effective and prompt intervention on the part of clinicians, the results of several studies indicate that patients with depression consistently receive no or low levels of antidepressant therapy. It is hoped that, through continued education of health care providers and patients about the consequences of depression, the issue of undertreatment of this serious illness will be resolved.



2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Abdul Alif AH ◽  
Muhammad Lokman M ◽  
Afzan MY ◽  
Siew PL ◽  
Nik Fakhuruddin NH ◽  
...  

The utilization of insecticide in a household environment is a necessity especially for those living in the tropical country such as Malaysia. Tropical climate with high humidity and urbanization lead to pests breeding problem hence contributing to the spread of vector diseases such as dengue. Household insecticide such as aerosol sprays, coils and mats are made from a combination of chemicals from type 1 pyrethroid group which are recognized as safe and have minimal toxic effects on human. However, there have been cases of accidental and intentional insecticide poisoning which demonstrates the lack of studies on factors of knowledge, attitude and practice of insecticide usage, the exposure as well as clinical presentation since the symptoms are similar to other compounds which may lead to misdiagnosis. These insecticide chemicals do not only exert toxic effects to pest but to human too due to its highly toxic characteristic which causes diseases such as asthma, cancer, and other diseases following short or long-term exposure to the chemicals. As a result, there is a growing community health concern regarding the uncertainty and risk of insecticide exposure to human. Thus, the risk assessment of community’s knowledge, attitude and practice regarding the insecticide are essential in aiding towards the development of improving insecticide profile, safer insecticide handling and exploration of insecticide alternative. This will result in better insecticide awareness, as well as minimize the insecticide risk exposure and its adverse health effects to the community.



eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Eva Malatinkova ◽  
Ward De Spiegelaere ◽  
Pawel Bonczkowski ◽  
Maja Kiselinova ◽  
Karen Vervisch ◽  
...  

Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation. We compared HIV-1 reservoirs in a cross-sectional study using polymerase chain reaction-based techniques in blood and tissue of early-treated seroconverters, late-treated patients, ART-naïve seroconverters, and long-term non-progressors (LTNPs) who have spontaneous virological control without treatment. A decade of early ART reduced the total and integrated HIV-1 DNA levels compared with later treatment initiation, but not reaching the low levels found in LTNPs. Total HIV-1 DNA in rectal biopsies did not differ between cohorts. Importantly, lower viral transcription (HIV-1 unspliced RNA) and enhanced immune preservation (CD4/CD8), reminiscent of LTNPs, were found in early compared to late-treated patients. This suggests that early treatment is associated with some immunovirological features of LTNPs that may improve the outcome of future interventions aimed at a functional cure.



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