Gold-stabilized carboxymethyl dextran nanoparticles for image-guided photodynamic therapy of cancer

2017 ◽  
Vol 5 (35) ◽  
pp. 7319-7327 ◽  
Author(s):  
Minchang Lee ◽  
Hansang Lee ◽  
N. Vijayakameswara Rao ◽  
Hwa Seung Han ◽  
Sangmin Jeon ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Image Guided ◽  
Photodynamic Therapy Of Cancer ◽  
Carboxymethyl Dextran

Photodynamic therapy (PDT) has been extensively investigated to treat cancer since it induces cell death through the activation of photosensitizers by light.

scholarly journals Cell Death Pathways in Photodynamic Therapy of Cancer

Cancers ◽  
2011 ◽  
Vol 3 (2) ◽  
pp. 2516-2539 ◽  
Author(s):  
Pawel Mroz ◽  
Anastasia Yaroslavsky ◽  
Gitika B Kharkwal ◽  
Michael R. Hamblin
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Cell Death Pathways ◽  
Photodynamic Therapy Of Cancer

scholarly journals PEGylated Purpurin 18 with Improved Solubility: Potent Compounds for Photodynamic Therapy of Cancer

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4477 ◽  
Author(s):  
Vladimíra Pavlíčková ◽  
Silvie Rimpelová ◽  
Michal Jurášek ◽  
Kamil Záruba ◽  
Jan Fähnrich ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Intracellular Localization ◽  
Zinc Ion ◽  
Cell Uptake ◽  
Oxygen Generation ◽  
Photodynamic Therapy Of Cancer ◽  
Predominant Type ◽  
Inhibitory Compound ◽  
Compound Concentration

Purpurin 18 derivatives with a polyethylene glycol (PEG) linker were synthesized as novel photosensitizers (PSs) with the goal of using them in photodynamic therapy (PDT) for cancer. These compounds, derived from a second-generation PS, exhibit absorption at long wavelengths; considerable singlet oxygen generation and, in contrast to purpurin 18, have higher hydrophilicity due to decreased logP. Together, these properties make them potentially ideal PSs. To verify this, we screened the developed compounds for cell uptake, intracellular localization, antitumor activity and induced cell death type. All of the tested compounds were taken up into cancer cells of various origin and localized in organelles known to be important PDT targets, specifically, mitochondria and the endoplasmic reticulum. The incorporation of a zinc ion and PEGylation significantly enhanced the photosensitizing efficacy, decreasing IC50 (half maximal inhibitory compound concentration) in HeLa cells by up to 170 times compared with the parental purpurin 18. At effective PDT concentrations, the predominant type of induced cell death was apoptosis. Overall, our results show that the PEGylated derivatives presented have significant potential as novel PSs with substantially augmented phototoxicity for application in the PDT of cervical, prostate, pancreatic and breast cancer.

Dual-targeted activatable photosensitizers with aggregation-induced emission (AIE) characteristics for image-guided photodynamic cancer cell ablation

2016 ◽  
Vol 4 (1) ◽  
pp. 169-176 ◽  
Author(s):  
Youyong Yuan ◽  
Shidang Xu ◽  
Chong-Jing Zhang ◽  
Ruoyu Zhang ◽  
Bin Liu
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Normal Cell ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Cell Ablation

The currently available photosensitizers (PSs) for photodynamic therapy (PDT) can easily lead to undesirable normal cell death due to their intrinsic photo-toxicity and lack of selectivity for cancer cells.

scholarly journals Hybrid Inorganic-Organic Core-Shell Nanodrug Systems in Targeted Photodynamic Therapy of Cancer

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1773
Author(s):  
Gauta Gold Matlou ◽  
Heidi Abrahamse
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Colloidal Stability ◽  
Therapeutic Agents ◽  
Organic Polymer ◽  
Cancer Site ◽  
Core Shell ◽  
Synthesis Methods ◽  
Photodynamic Therapy Of Cancer ◽  
Targeted Photodynamic Therapy

Hybrid inorganic-organic core-shell nanoparticles (CSNPs) are an emerging paradigm of nanodrug carriers in the targeted photodynamic therapy (TPDT) of cancer. Typically, metallic cores and organic polymer shells are used due to their submicron sizes and high surface to volume ratio of the metallic nanoparticles (NPs), combined with enhances solubility, stability, and absorption sites of the organic polymer shell. As such, the high loading capacity of therapeutic agents such as cancer specific ligands and photosensitizer (PS) agents is achieved with desired colloidal stability, drug circulation, and subcellular localization of the PS agents at the cancer site. This review highlights the synthesis methods, characterization techniques, and applications of hybrid inorganic-organic CSNPs as loading platforms of therapeutic agents for use in TPDT. In addition, cell death pathways and the mechanisms of action that hybrid inorganic-organic core-shell nanodrug systems follow in TPDT are also reviewed. Nanodrug systems with cancer specific properties are able to localize within the solid tumor through the enhanced permeability effect (EPR) and bind with affinity to receptors on the cancer cell surfaces, thus improving the efficacy of short-lived cytotoxic singlet oxygen. This ability by nanodrug systems together with their mechanism of action during cell death forms the core basis of this review and will be discussed with an overview of successful strategies that have been reported in the literature.

p53 family members – important messengers in cell death signaling in photodynamic therapy of cancer?

2015 ◽  
Vol 14 (8) ◽  
pp. 1390-1396 ◽  
Author(s):  
Pilar Acedo ◽  
Joanna Zawacka-Pankau
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Cellular Stress ◽  
Family Members ◽  
P53 Family ◽  
Photodynamic Therapy Of Cancer ◽  
Cell Death Signaling

p53 is a powerful tumor suppressor and a critical sensor of cellular stress. This Perspective summarizes the role of p53 in response of cancer cells to photodynamic therapy – a field not fully explored yet.

Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsions

2017 ◽  
Author(s):  
Ellen Sletten ◽  
Rachael A. Day ◽  
Daniel A. Estabrook ◽  
Jessica K. Logan
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Induce Cell Death ◽  
Perfluorocarbon Nanoemulsions

<p>Photodynamic therapy (PDT) requires photosensitizer, light, and oxygen to induce cell death. The majority of efforts to advance PDT focus only on the first two components. Here, we employ perfluorocarbon nanoemulsions to simultaneously deliver oxygen and photosensitizer. We find that the implementation of fluorous soluble photosensitizers enhances the efficacy of PDT. </p>

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