A new tool to attack biofilms: driving magnetic iron-oxide nanoparticles to disrupt the matrix

Nanoscale ◽  
2019 ◽  
Vol 11 (14) ◽  
pp. 6905-6915 ◽  
Author(s):  
Jie Li ◽  
Rachel Nickel ◽  
Jiandong Wu ◽  
Francis Lin ◽  
Johan van Lierop ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Extracellular Matrix ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Bacterial Resistance ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Dc Magnetic Field ◽  
Planktonic Bacteria ◽  
The Matrix

Removing robust MRSA biofilms using magnetic nanoparticles (MNPs) under AC and DC magnetic field is demonstrated. Despite being non-toxic to planktonic bacteria, MNPs can bring damage to the extracellular matrix of biofilms and remove them from surfaces without inducing bacterial resistance.

scholarly journals DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD

2017 ◽  
Vol 16 (2) ◽  
pp. 145-148
Author(s):  
Sergey Kolesov ◽  
Andrey Panteleyev ◽  
Maxim Sazhnev ◽  
Arkadiy Kazmin
Keyword(s):  
Magnetic Field ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Iron Oxide ◽  
Evoked Potential ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Potential Amplitude ◽  
Cord Injury

ABSTRACT Objective: To determine the amount of loss of function after spinal cord transection of varying extents, and whether magnetic iron oxide nanoparticles, in combination with an external magnetic field, improve the rate of subsequent functional recovery in rats. Methods: The animals were divided into groups with 50%, 80% and complete spinal cord transection. The animals of all three study groups were administered magnetic iron oxide nanoparticle suspension to the area of injury. The three control groups were not administered magnetic nanoparticles, but had corresponding transection levels. All animals were exposed to a magnetic field for 4 weeks. Loss of postoperative function and subsequent recovery were assessed using the BBB motor function scale and somatosensory evoked potential monitoring on the first day after surgery, and then weekly. Terminal histological analysis was also conducted in all the groups. Results: The animals in the control or complete transection groups did not demonstrate statistically significant improvement in either the BBB scores or evoked potential amplitude over the four-week period. In the group with 50% transection, however, a statistically significant increase in evoked potential amplitude and BBB scores was observed four weeks after surgery, with the highest increase during the second week of the study. In the group with 80% transection, only improvement in evoked potential amplitude was statistically significant, although less pronounced than in the 50% transection group. Conclusion: The use of magnetic iron oxide nanoparticles in combination with a magnetic field leads to higher rates of functional recovery after spinal cord injury in laboratory animals. The mechanism of this functional improvement needs further investigation.

Folic acid conjugated magnetic iron oxide nanoparticles for nondestructive separation and detection of ovarian cancer cells from whole blood

2016 ◽  
Vol 4 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Wenting Liu ◽  
Liju Nie ◽  
Fulai Li ◽  
Zoraida P. Aguilar ◽  
Hong Xu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Folic Acid ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Whole Blood ◽  
Ovarian Cancer Cells ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles

An effective method for separation and detection of ovarian cancer cells from whole blood using folic acid conjugated magnetic nanoparticles.

scholarly journals Iron Oxide Nanoparticles for Magnetic Hyperthermia

SPIN ◽  
2019 ◽  
Vol 09 (02) ◽  
pp. 1940001 ◽  
Author(s):  
N. A. Usov
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Stochastic Equation ◽  
Sharp Decrease ◽  
Dipole Interaction ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles

Assemblies of magnetic nanoparticles show a great potential for application in biomedicine, particularly, magnetic hyperthermia. However, to achieve desired therapeutic effect in magnetic hyperthermia, the assembly of nanoparticles should have a sufficiently high specific absorption rate (SAR) in alternating magnetic field of moderate amplitude and frequency. Using the Landau–Lifshitz stochastic equation, it is shown that dilute assemblies of iron oxide nanoparticles of optimal diameters are capable of providing SAR of the order of 400–600[Formula: see text]W/g in alternating magnetic field with the amplitude [Formula: see text][Formula: see text]Oe in the frequency range f = 300–500[Formula: see text]kHz. Unfortunately, in dense clusters of magnetic nanoparticles, which are often formed in a biological medium, there is a sharp decrease in SAR due to the influence of strong magneto-dipole interaction of closest nanoparticles. To overcome this difficulty, it is suggested covering the nanoparticles with nonmagnetic shells of sufficient thickness or using non-single-domain nanoparticles being in magnetization curling states.

Surface active magnetic iron oxide nanoparticles for extracting metal nanoparticles across an aqueous–organic interface

2019 ◽  
Vol 7 (34) ◽  
pp. 10623-10634 ◽  
Author(s):  
Meenakshi Verma ◽  
Kultar Singh ◽  
Mandeep Singh Bakshi
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Metal Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Gemini Surfactants ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Surface Active

Highly surface active magnetic nanoparticles (Fe3O4 NPs) were synthesized by using tetraalkylammonium and imidazolium Gemini surfactants.

scholarly journals Nanocomposites comprised of homogeneously dispersed magnetic iron-oxide nanoparticles and poly(methyl methacrylate)

2018 ◽  
Vol 9 ◽  
pp. 1613-1622 ◽  
Author(s):  
Sašo Gyergyek ◽  
David Pahovnik ◽  
Ema Žagar ◽  
Alenka Mertelj ◽  
Rok Kostanjšek ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Methyl Methacrylate ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Uniform Loading ◽  
Magnetic Iron Oxide ◽  
Induced Hyperthermia ◽  
Pmma Matrix

Nanocomposites with a high, uniform loading of magnetic nanoparticles are very desirable for applications such as electromagnetic shielding and cancer treatment based on magnetically induced hyperthermia. In this study, a simple and scalable route for preparing nanocomposites with a high, uniform loading of magnetic nanoparticles is presented. The magnetic iron-oxide nanoparticles were functionalized with a methacrylate-based monomer that copolymerized in a toluene solution with the methyl methacrylate (MMA) monomer. The resulting suspension of magnetic nanoparticles decorated with poly(methyl methacrylate) (PMMA) chains in toluene were colloidal, even in the presence of a magnetic field gradient. Nanocomposites were precipitated from these suspensions. The transmission electron microscopy investigation of the prepared nanocomposites revealed that the magnetic nanoparticles were homogeneously dispersed in the PMMA matrix, even in amounts up to 53 wt %. The uniform dispersion of the nanoparticles in the PMMA matrix was attributed to the good solvation of the grafted PMMA chains from the magnetic nanoparticles by the PMMA chains of the matrix. The nanocomposites were superparamagnetic and exhibited large values for the saturation magnetization of up to 36 emu/g. Moreover, the nanocomposite with the largest amount of incorporated nanoparticles exhibited relatively large values for the specific power loss when subjected to alternating magnetic fields, giving this material great potential for the magnetically induced hyperthermia-based treatment of cancer.

scholarly journals In Vivo Imaging of Local Gene Expression Induced by Magnetic Hyperthermia

2017 ◽  
Author(s):  
Olivier Sandre ◽  
Coralie Genevois ◽  
Eneko Garaio ◽  
Laurent Adumeau ◽  
Stéphane Mornet ◽  
...  
Keyword(s):  
Gene Expression ◽  
Magnetic Field ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Non Invasive ◽  
Nanoparticles Dispersions

The present work aims to demonstrate that colloidal dispersions of magnetic iron oxide nanoparticles stabilized with dextran macromolecules placed in an alternating magnetic field can not only produce heat, but also that these particles could be used in vivo for local and non-invasive deposition of a thermal dose sufficient to trigger thermo-induced gene expression. Iron oxide nanoparticles were first characterized in vitro on a bio-inspired setup, and then they were assayed in vivo using a transgenic mouse strain expressing the luciferase reporter gene under transcriptional control of a thermosensitive promoter. Iron oxide nanoparticles dispersions were applied topically on the mouse skin or injected sub-cutaneously with Matrigel™ to generate so called pseudo tumors. Temperature was monitored continuously with a feedback loop to control the power of the magnetic field generator and to avoid overheating. Thermo-induced luciferase expression was followed by bioluminescence imaging 6 hours after heating. We showed that dextran-coated magnetic iron oxide nanoparticles dispersions were able to induce in vivo mild hyperthermia compatible with thermo-induced gene expression in surrounding tissues and without impairing cell viability. These data open new therapeutic perspectives for using mild magnetic hyperthermia as non-invasive modulation of tumor microenvironment by local thermo-induced gene expression or drug release.

Deep Eutectic Solvent Electrolysis for Preparing Water-Soluble Magnetic Iron Oxide Nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Haiyang Jia ◽  
Jiawei Sun ◽  
Meng Dong ◽  
Hui Dong ◽  
Hongtao Zhang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Deep Eutectic Solvent ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide

Magnetic iron oxide nanoparticles have been proven versatile applications in biomedicine. Although numerous strategies have been developed to synthsize hydrophilic magnetic nanoparticles, it is still a challenge in quantity and...

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