Zwitterionic carbon dot-encapsulating pH-responsive mesoporous silica nanoparticles for NIR light-triggered photothermal therapy through pH-controllable release

2019 ◽  
Vol 7 (6) ◽  
pp. 2600-2610 ◽  
Author(s):  
Benny Ryplida ◽  
Gibaek Lee ◽  
Insik In ◽  
Sung Young Park
Keyword(s):  
Mesoporous Silica ◽  
Photothermal Therapy ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Ph Responsive ◽  
Mesoporous Silica Nanoparticle ◽  
Carbon Dot ◽  
Image Guided ◽  
Nir Light ◽  
Controllable Release

Here, we designed a pH-responsive Indocyanine Green (ICG)-loaded zwitterionic fluorescent carbon dot (CD)-encapsulating mesoporous silica nanoparticle (MSN) for pH-tunable image-guided photothermal therapy.

Metal-Phenolic Encapsulated Mesoporous Silica Nanoparticles for pH-Responsive Drug Delivery and Magnetic Resonance Imaging

2018 ◽  
Vol 232 (9-11) ◽  
pp. 1733-1740 ◽  
Author(s):  
Yan Chen ◽  
Juan Wang ◽  
Jianhua Liu ◽  
Lehui Lu
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Burst Release ◽  
Acidic Environment ◽  
Ph Responsive ◽  
Resonance Imaging ◽  
Mesoporous Silica Nanoparticle ◽  
Longitudinal Relaxivity

Abstract The anticancer drug doxorubicin (DOX) is locked in the mesoporous silica nanoparticle by coating FeIII-TA polymer, and its burst release can be achieved under acidic environment, along with the decreased longitudinal relaxivity. This nanoplatform shows great potential to monitoring the drug delivery process and the fate of the nanocarrier.

Dual pH-responsive mesoporous silica nanoparticles for efficient combination of chemotherapy and photodynamic therapy

2015 ◽  
Vol 3 (23) ◽  
pp. 4707-4714 ◽  
Author(s):  
Xuemei Yao ◽  
Xiaofei Chen ◽  
Chaoliang He ◽  
Li Chen ◽  
Xuesi Chen
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Ph Responsive ◽  
Mesoporous Silica Nanoparticle

By metallo-supramolecular coordinated interaction between Zn-Por and histidine, a dual pH-responsive mesoporous silica nanoparticle (MSN)-based drug delivery system has been fabricated for synergistic chemo-photodynamic therapy.

scholarly journals Dy-DOTA integrated mesoporous silica nanoparticles as promising ultrahigh field magnetic resonance imaging contrast agents

Nanoscale ◽  
2018 ◽  
Vol 10 (45) ◽  
pp. 21041-21045 ◽  
Author(s):  
Xiao-Yu Zheng ◽  
Juan Pellico ◽  
Alexandr A. Khrapitchev ◽  
Nicola R. Sibson ◽  
Jason J. Davis
Keyword(s):  
Magnetic Resonance Imaging ◽  
Mesoporous Silica ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Outer Sphere ◽  
Resonance Imaging ◽  
Mesoporous Silica Nanoparticle ◽  
Ultrahigh Field ◽  
Magnetic Resonance Imaging Contrast ◽  
Sphere Mechanism

Integrating Dy-DOTA motifs into mesoporous silica nanoparticle scaffolds significantly amplifies the ultrahigh field T2 relaxivity via a Curie outer-sphere mechanism.

Multifunctional Mesoporous Silica Nanoparticles with Thermal-Responsive Gatekeeper for NIR Light-Triggered Chemo/Photothermal-Therapy

Small ◽  
2016 ◽  
Vol 12 (31) ◽  
pp. 4286-4298 ◽  
Author(s):  
Qi Lei ◽  
Wen-Xiu Qiu ◽  
Jing-Jing Hu ◽  
Peng-Xi Cao ◽  
Cheng-Hui Zhu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Photothermal Therapy ◽  
Mesoporous Silica Nanoparticles ◽  
Nir Light

Reduced graphene oxide gated mesoporous silica nanoparticles as a versatile chemo-photothermal therapy system through pH controllable release

2015 ◽  
Vol 3 (30) ◽  
pp. 6377-6384 ◽  
Author(s):  
Ting Ting Wang ◽  
Jing Lan ◽  
Yue Zhang ◽  
Zhu Lian Wu ◽  
Chun Mei Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Reduced Graphene Oxide ◽  
Photothermal Therapy ◽  
Mesoporous Silica Nanoparticles ◽  
Reduced Graphene ◽  
Controllable Release ◽  
Acidic Environments

A multifunctional drug delivery system involving coupling photothermal therapy and chemotherapy together was developed, which based on the combination of rGO and MSNs, wherein the cargo molecules could be released in acidic environments due to the cleavage of the CN bond of Schiff bases.

Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (39) ◽  
pp. 30640-30646 ◽  
Author(s):  
Yue Yan ◽  
Jie Fu ◽  
Xin Liu ◽  
Tianfu Wang ◽  
Xiuyang Lu
Keyword(s):  
Mesoporous Silica ◽  
Click Chemistry ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Functionalized Mesoporous Silica ◽  
Doxorubicin Release

An intracellular acidity-triggered doxorubicin release from “click chemistry” functionalized mesoporous silica nanoparticle was demonstrated.

Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis

Nanoscale ◽  
2018 ◽  
Vol 10 (19) ◽  
pp. 9141-9152 ◽  
Author(s):  
Xuyao Zhang ◽  
Jingyun Luan ◽  
Wei Chen ◽  
Jiajun Fan ◽  
Yanyang Nan ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Nlrp3 Inflammasome ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Underlying Mechanism ◽  
Inflammasome Activation ◽  
Mesoporous Silica Nanoparticle ◽  
Caspase 1 ◽  
Nlrp3 Inflammasome Activation

Novel insights into mesoporous silica nanoparticle (MSN)-induced hepatotoxicity and the underlying mechanism, facilitating an increase of the biosafety of MSNs.

Graphene quantum dot-decorated mesoporous silica nanoparticles for high aspirin loading capacity and its pH-triggered release

2016 ◽  
Vol 8 (12) ◽  
pp. 2561-2567 ◽  
Author(s):  
Shaping Huang ◽  
Liping Song ◽  
Zhidong Xiao ◽  
Yue Hu ◽  
Meiwen Peng ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Quantum Dot ◽  
Mesoporous Silica ◽  
Mesoporous Silica Nanoparticles ◽  
Graphene Quantum Dots ◽  
Silica Nanoparticle ◽  
Loading Capacity ◽  
Triggered Release ◽  
Mesoporous Silica Nanoparticle ◽  
Graphene Quantum Dot

In this paper, fluorescent graphene quantum dots (GQDs) grafted onto the surface of mesoporous silica nanoparticle (MSN) vehicles were prepared and characterized.

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