Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery

PEG-PLA micelles are modified with F3 peptides, thus endowing the micelles with active-targeting ability due to the nucleolin-binding ability of the F3 peptides.

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Doxorubicin-Loaded Tumor-Targeting Peptide-Decorated Polypeptide Nanoparticles for Treating Primary Orthotopic Colon Cancer

Frontiers in Pharmacology ◽

10.3389/fphar.2021.744811 ◽

2021 ◽

Vol 12 ◽

Author(s):

Guoliang Liu ◽

Min Wang ◽

Hongyu He ◽

Jiannan Li

Keyword(s):

Colorectal Cancer ◽

Drug Delivery ◽

Colon Cancer ◽

Disulfide Bonds ◽

Tumor Targeting ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Antitumor Properties ◽

Targeting Peptide ◽

Tumor Targeting Peptide

Colorectal cancer is the third most common malignant disease worldwide, and chemotherapy has been the standard treatment for colorectal cancer. However, the therapeutic effects of chemotherapy are unsatisfactory for advanced and recurrent colorectal cancers. Thus, increasing the treatment efficacy of chemotherapy in colorectal cancer is a must. In this study, doxorubicin (DOX)-loaded tumor-targeting peptide-decorated mPEG-P(Phe-co-Cys) nanoparticles were developed to treat orthotopic colon cancer in mice. The peptide VATANST (STP) can specifically bind with vimentin highly expressed on the surface of colon cancer cells, thus achieving the tumor-targeting effects. The nanoparticles are core-shell structured, which can protect the loaded DOX while passing through the blood flow and increase the circulation time. The disulfide bonds within the nanoparticles are sensitive to the glutathione-rich microenvironment of tumor tissues. Rupture of disulfide bonds of the nanoparticles leads to the continuous release of DOX, thus resulting in the apoptosis of the tumor cells. The in vivo experiments in mice with orthotopic colon cancer demonstrated that the synthesized DOX-loaded tumor-targeting peptide-decorated polypeptide nanoparticles showed properties of drug delivery systems and exhibited good antitumor properties. The synthesized nanoparticles show appropriate properties as one of the drug delivery systems and exhibit good antitumor properties after encapsulating DOX.

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Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

Current Pharmaceutical Design ◽

10.2174/1381612825666190903154847 ◽

2019 ◽

Vol 25 (37) ◽

pp. 3917-3926

Author(s):

Sajjad Molavipordanjani ◽

Seyed Jalal Hosseinimehr

Keyword(s):

Drug Delivery ◽

Iron Oxide ◽

Medical Imaging ◽

Cancer Diagnosis ◽

Carbon Nanoparticles ◽

Tumor Targeting ◽

Polymeric Nanoparticles ◽

Inorganic Nanoparticles ◽

Active Targeting ◽

Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

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A chimera of green fluorescent protein with gelatinase binding and tumor targeting peptide

Protein Expression and Purification ◽

10.1016/j.pep.2010.03.023 ◽

2010 ◽

Vol 72 (2) ◽

pp. 234-237 ◽

Cited By ~ 3

Author(s):

Justus Reunanen ◽

Tanja-Maria Ranta ◽

Oula Peñate-Medina ◽

Juho Suojanen ◽

Timo Sorsa ◽

...

Keyword(s):

Green Fluorescent Protein ◽

Tumor Targeting ◽

Fluorescent Protein ◽

Targeting Peptide ◽

Tumor Targeting Peptide ◽

Green Fluorescent

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In vitro evaluation of tumor targeting ability of a parenteral enoxaparin-coated self-emulsifying drug delivery system

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2019.101144 ◽

2019 ◽

Vol 53 ◽

pp. 101144 ◽

Cited By ~ 1

Author(s):

Simona Giarra ◽

Noemi Lupo ◽

Virginia Campani ◽

Alfonso Carotenuto ◽

Laura Mayol ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Tumor Targeting ◽

In Vitro Evaluation ◽

Targeting Ability

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GRPR-targeted SPECT imaging using a novel bombesin-based peptide for colorectal cancer detection

Biomaterials Science ◽

10.1039/d0bm01432j ◽

2020 ◽

Vol 8 (23) ◽

pp. 6764-6772 ◽

Cited By ~ 1

Author(s):

Peifei Liu ◽

Yuanbiao Tu ◽

Ji Tao ◽

Zicun Liu ◽

Fang Wang ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Detection ◽

Tumor Targeting ◽

Spect Imaging ◽

Intestinal Activity ◽

Cancer Models ◽

Pharmacokinetic Properties ◽

Targeting Peptide ◽

Targeting Ability

The designed novel targeting peptide GB-6 binding to GRPR possesses more favorable pharmacokinetic properties with lower intestinal activity as well as superior tumor-targeting ability in colorectal cancer models than BBN7–14.

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