scholarly journals Gold nanoclusters for biomedical applications: toward in vivo studies

2020 ◽  
Vol 8 (11) ◽  
pp. 2216-2232 ◽  
Author(s):  
Estelle Porret ◽  
Xavier Le Guével ◽  
Jean-Luc Coll
Keyword(s):  
Biomedical Applications ◽  
Gold Nanoclusters ◽  
In Vivo Studies ◽  
Therapeutic Properties ◽  
Theranostic Agents

In parallel with the rapidly growing and widespread use of nanomedicine in the clinic, we are also witnessing the development of so-called theranostic agents that combine diagnostic and therapeutic properties.

scholarly journals Overview of DNA Self-Assembling: Progresses in Biomedical Applications

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 268 ◽  
Author(s):  
Andreia Jorge ◽  
Ramon Eritja
Keyword(s):  
Programming Languages ◽  
Biomedical Applications ◽  
Great Promise ◽  
Dna Nanostructures ◽  
Modular Assembly ◽  
Molecular Programming ◽  
Self Assembling ◽  
Theranostic Agents ◽  
Assembly Principles

Molecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells. In recent decades, material science has been inspired by the nature’s assembly principles to create artificially higher-order structures customized with therapeutic and targeting molecules, organic and inorganic fluorescent probes that have opened new perspectives for biomedical applications. Among these novel man-made materials, DNA nanostructures hold great promise for the modular assembly of biocompatible molecules at the nanoscale of multiple shapes and sizes, designed via molecular programming languages. Herein, we summarize the recent advances made in the designing of DNA nanostructures with special emphasis on their application in biomedical research as imaging and diagnostic platforms, drug, gene, and protein vehicles, as well as theranostic agents that are meant to operate in-cell and in-vivo.

Multifunctionalized carbon nanotubes as advanced multimodal nanomaterials for biomedical applications

2012 ◽  
Vol 1 (1) ◽  
pp. 17-29 ◽  
Author(s):  
Giuseppe Lamanna ◽  
Alessia Battigelli ◽  
Cécilia Ménard-Moyon ◽  
Alberto Bianco
Keyword(s):  
Carbon Nanotubes ◽  
Diagnostic Imaging ◽  
Biomedical Applications ◽  
Therapeutic Modalities ◽  
Different Types ◽  
Therapeutic Properties ◽  
New Strategies ◽  
Combine Diagnosis

AbstractThe increasing importance of nanotechnology in the field of biomedical applications has encouraged the development of new nanomaterials endowed with multiple functions. Novel nanoscale drug delivery systems with diagnostic, imaging and therapeutic properties hold many promises for the treatment of different types of diseases, including cancer, infection and neurodegenerative syndromes. Functionalized carbon nanotubes (CNTs) are one of the most recent type of nanomaterial developed in biomedicine as they can be designed and imparted with multimodal capabilities. Indeed, the possibility of inserting different functionalities on CNTs is opening the possibility to exploit them on new strategies that combine diagnosis with improved therapeutic efficacies. In this review, we describe the different approaches that have been recently developed to generate multifunctionalized CNTs for biomedical applications. In particular, covalent and non-covalent double and triple functionalization methods are discussed, putting in evidence their use in vitro and in vivo and highlighting the advantages and the drawbacks of these new systems. Preclinical studies have demonstrated that multifunctional CNTs are highly promising when combining diagnostic, imaging and therapeutic modalities.

scholarly journals Evaluation of Radioiodinated Fluoronicotinamide/Fluoropicolinamide-Benzamide Derivatives as Theranostic Agents for Melanoma

2020 ◽  
Vol 21 (18) ◽  
pp. 6597
Author(s):  
Chao-Cheng Chen ◽  
Yang-Yi Chen ◽  
Yi-Hsuan Lo ◽  
Ming-Hsien Lin ◽  
Chih-Hsien Chang ◽  
...  
Keyword(s):  
Absorbed Dose ◽  
Radiochemical Yield ◽  
Amelanotic Melanoma ◽  
In Vivo Studies ◽  
Log P ◽  
Theranostic Agent ◽  
Biodistribution Studies ◽  
Theranostic Agents

Malignant melanoma is the most harmful type of skin cancer and its incidence has increased in this past decade. Early diagnosis and treatment are urgently desired. In this study, we conjugated picolinamide/nicotinamide with the pharmacophore of 131I-MIP-1145 to develop 131I-iodofluoropicolinamide benzamide (131I-IFPABZA) and 131I-iodofluoronicotiamide benzamide (131I-IFNABZA) with acceptable radiochemical yield (40 ± 5%) and high radiochemical purity (>98%). We also presented their biological characteristics in melanoma-bearing mouse models. 131I-IFPABZA (Log P = 2.01) was more lipophilic than 131I-IFNABZA (Log P = 1.49). B16F10-bearing mice injected with 131I-IFNABZA exhibited higher tumor-to-muscle ratio (T/M) than those administered with 131I-IFPABZA in planar γ-imaging and biodistribution studies. However, the imaging of 131I-IFNABZA- and 131I-IFPABZA-injected mice only showed marginal tumor uptake in A375 amelanotic melanoma-bearing mice throughout the experiment period, indicating the high binding affinity of these two radiotracers to melanin. Comparing the radiation-absorbed dose of 131I-IFNABZA with the melanin-targeted agents reported in the literature, 131I-IFNABZA exerts lower doses to normal tissues on the basis of similar tumor dose. Based on the in vitro and in vivo studies, we clearly demonstrated the potential of using 131I-IFNABZA as a theranostic agent against melanoma.

Gold Nanoparticles as Targeted Delivery Systems and Theranostic Agents in Cancer Therapy

2019 ◽  
Vol 26 (35) ◽  
pp. 6493-6513 ◽  
Author(s):  
Alexandra Mioc ◽  
Marius Mioc ◽  
Roxana Ghiulai ◽  
Mirela Voicu ◽  
Roxana Racoviceanu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Anticancer Agents ◽  
Targeted Delivery ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
In Vivo Studies ◽  
Theranostic Agents ◽  
Targeted Delivery Systems

Cancer is still a leading cause of death worldwide, while most chemotherapies induce nonselective toxicity and severe systemic side effects. To address these problems, targeted nanoscience is an emerging field that promises to benefit cancer patients. Gold nanoparticles are nowadays in the spotlight due to their many well-established advantages. Gold nanoparticles are easily synthesizable in various shapes and sizes by a continuously developing set of means, including chemical, physical or eco-friendly biological methods. This review presents gold nanoparticles as versatile therapeutic agents playing many roles, such as targeted delivery systems (anticancer agents, nucleic acids, biological proteins, vaccines), theranostics and agents in photothermal therapy. They have also been outlined to bring great contributions in the bioimaging field such as radiotherapy, magnetic resonance angiography and photoacoustic imaging. Nevertheless, gold nanoparticles are therapeutic agents demonstrating its in vitro anti-angiogenic, anti-proliferative and pro-apoptotic effects on various cell lines, such as human cervix, human breast, human lung, human prostate and murine melanoma cancer cells. In vivo studies have pointed out data regarding the bioaccumulation and cytotoxicity of gold nanoparticles, but it has been emphasized that size, dose, surface charge, sex and especially administration routes are very important variables.

Pegylated Drug Delivery Systems: From Design to Biomedical Applications

Nano LIFE ◽  
2016 ◽  
Vol 06 (03n04) ◽  
pp. 1642002 ◽  
Author(s):  
Fei Liu ◽  
Yuan Sun ◽  
Chen Kang ◽  
Hongyan Zhu
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Simple Procedure ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Circulation Time ◽  
In Vivo Studies

Pegylation, as a simple procedure to attach hydrophilic polyethylene glycol (PEG) onto therapeutic molecule or drug carriers has been utilized widely to deliver small molecules, proteins and peptides. It was first reported in 1970s by Dr. Frank Davis of Rutgers University and Dr. Abuchowsky in the studies of PEG modified albumin and catalase. The significance of this method at that time was able to successfully modify the enzyme with better hydrophilicity but also keep the enzymatic activity. The employment of PEG has provided superior stability of drug delivery systems (DDS) and enhanced the circulation time in vivo. Simple conjugation of PEG chains with various molecular weights enables the possibility to regulate the properties of desired DDS and led to important contribution in targeting therapy and diagnosis. Pegylation has been reported to be able to protect peptides by shielding antigenic epitopes from reticuloendothelial (RES) clearance and avoid enzymes being recognized by immune system and avoid early degradation. In addition, utilization of PEG in DDS are reported with enhanced delivery efficiency, prolonged circulation time and improved stability, especially active enzymes and peptides drug delivery. In this paper, we will conclude current studies about Pegylated DDS and their biomedical applications from both in vitro and in vivo studies.

scholarly journals Novel magnetic multicore nanoparticles designed for MPI and other biomedical applications: From synthesis to first in vivo studies

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0190214 ◽  
Author(s):  
Harald Kratz ◽  
Matthias Taupitz ◽  
Angela Ariza de Schellenberger ◽  
Olaf Kosch ◽  
Dietmar Eberbeck ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
In Vivo Studies

scholarly journals Pd-based bimetallic catalysts for HET-PHIP

2021 ◽  
Author(s):  
Dudari B. Burueva ◽  
Aleksandr Y. Stakheev ◽  
Igor V. Koptyug
Keyword(s):  
Bimetallic Catalysts ◽  
Biomedical Applications ◽  
Heterogeneous Catalysts ◽  
In Vivo Studies ◽  
Catalytically Active ◽  
Spin Isomers ◽  
Heterogeneous Hydrogenation ◽  
H2 Addition ◽  
Free Gases

Abstract. Production of hyperpolarized catalyst-free gases and liquids by heterogeneous hydrogenation with parahydrogen (HET-PHIP) can be useful for various technical as well as biomedical applications, including in vivo studies, investigations of mechanisms of industrially important catalytic processes, enrichment of nuclear spin isomers of polyatomic gases, and more. In this regard, the wide systematic search for heterogeneous catalysts effective in pairwise H2 addition required for the observation of PHIP effects is crucial. Here in this work we demonstrate the competitive advantage of Pd-based bimetallic catalysts for HET-PHIP. The dilution of catalytically active Pd with less active Ag or In atoms provides the formation of atomically dispersed Pd1 sites on the surface of Pd-based bimetallic catalysts, which are significantly more selective toward pairwise H2 addition compared to the monometallic Pd. Furthermore, the choice of the dilution metal (Ag or In) has a pronounced effect on the efficiency of bimetallic catalysts in HET-PHIP, as revealed by comparing Pd-Ag and Pd-In bimetallic catalysts.

Additively manufactured titanium alloys and effect of hydroxyapatite coating for biomedical applications: A review

2020 ◽  
Vol 234 (11) ◽  
pp. 1450-1460
Author(s):  
Franklin Anene ◽  
Jaafar Aiza ◽  
Ismail Zainol ◽  
Azmah Hanim ◽  
Mohd Tahir Suraya
Keyword(s):  
Mechanical Properties ◽  
Additive Manufacturing ◽  
Titanium Alloys ◽  
Biomedical Applications ◽  
Hydroxyapatite Coating ◽  
In Vivo Studies ◽  
Processing Technologies ◽  
Treatment Processes

Metallic implants are extensively used to treat a spectrum of orthopaedic related disorders. Among the metals, titanium and its alloys are considered most excellent and indispensable material for the production of orthopaedic implants regarding their sterling mechanical properties and exceptional biocompatibility. Recently, rapid progress in developing non-toxic titanium-based alloys with modulus similar to that of human bone has inspired researchers globally. Thus, many studies have focused on titanium alloys, their heat treatment processes and several processing technologies. Additive manufacturing has been designed to enhance their mechanical properties tailored towards biomedical applications. Inarguably, the need to further improve on the implant’s biocompatibility with bodily environment for optimum service life is of great importance. Hence, hydroxyapatite coating provides an improvement as demonstrated by in vitro as well as in vivo studies. The present article critically reviews, based on recent scientific literatures, the progress made thus far in the development of titanium-based alloys, additive manufacturing processes and their heat and surface treatments tailored towards biomedical applications.

scholarly journals Therapeutic properties of VO(dmpp)2 as assessed by in vitro and in vivo studies in type 2 diabetic GK rats

2014 ◽  
Vol 131 ◽  
pp. 115-122 ◽  
Author(s):  
N. Domingues ◽  
J. Pelletier ◽  
C.-G. Ostenson ◽  
M.M.C.A. Castro
Keyword(s):  
In Vivo Studies ◽  
Gk Rats ◽  
Therapeutic Properties ◽  
Type 2 Diabetic

New Strategies for the Delivery of Some Natural Anti-oxidants with Therapeutic Properties

2019 ◽  
Vol 19 (13) ◽  
pp. 1030-1039 ◽  
Author(s):  
Elisabetta Esposito ◽  
Markus Drechsler ◽  
Carmelo Puglia ◽  
Rita Cortesi
Keyword(s):  
Cancer Progression ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Cellular Damage ◽  
In Vivo Studies ◽  
Cancer Cell Proliferation ◽  
Dietary Nutrients ◽  
Therapeutic Properties

Nature offers tremendous potential in the medicine field. Natural antioxidant molecules inhibit or quench free radical reactions and delay or inhibit cellular damage. In the last few years, researchers have been focusing on the health benefits of natural products. Particularly some dietary nutrients, such as curcumin, crocin, resveratrol, quercetin, coenzyme Q10, vitamin C, as well as some polysaccharides have been evaluated for their numerous and unique therapeutic properties. This review focuses on examples of pharmaceutical applications of natural anti-oxidants, with special regards to their encapsulation in micro- and nano- delivery systems. In vitro and in vivo studies have been conducted to investigate the physicochemical and pharmacological properties of different delivery systems containing antioxidant molecules. For instance, ethosomes, organogels, monoolein aqueous dispersions and solid lipid nanoparticle have been considered. It was found that micro and nanoencapsulation strategy can improve the solubility of lipophilic molecules and the chemical stability of labile antioxidants, thus prolonging their efficacy. In vitro and in vivo studies have highlighted that antioxidant encapsulation prolongs release kinetics, bioavailability and antioxidant effects. Noticeably, some encapsulated antioxidants effectively inhibit cancer cell proliferation, cell migration and colony formation, thus suppressing cancer progression.

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