scholarly journals Tough and injectable fiber reinforced calcium phosphate cement as an alternative to polymethylmethacrylate cement for vertebral augmentation: a biomechanical study

2020 ◽  
Vol 8 (15) ◽  
pp. 4239-4250
Author(s):  
Sónia de Lacerda Schickert ◽  
João Castro Pinto ◽  
John Jansen ◽  
Sander C. G. Leeuwenburgh ◽  
Jeroen J. J. P. van den Beucken
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Vinyl Alcohol ◽  
Ex Vivo ◽  
Biomechanical Study ◽  
Poly Vinyl Alcohol ◽  
Vertebral Augmentation ◽  
Fiber Reinforced

A novel injectable calcium phosphate cement, reinforced with poly(vinyl alcohol) fibers has been developed and demonstrated in vitro and ex vivo bio-mechanical suitability for vertebral augmentation procedures.

scholarly journals Stabilizing dental implants with a fiber-reinforced calcium phosphate cement: An in vitro and in vivo study

2020 ◽  
Vol 110 ◽  
pp. 280-288
Author(s):  
Sónia de Lacerda Schickert ◽  
John A Jansen ◽  
Ewald M. Bronkhorst ◽  
Jeroen JJP van den Beucken ◽  
Sander CG Leeuwenburgh
Keyword(s):  
Calcium Phosphate ◽  
Dental Implants ◽  
Calcium Phosphate Cement ◽  
In Vivo Study ◽  
Fiber Reinforced

In vitro biomineralization on poly(vinyl alcohol)/biphasic calcium phosphate hydrogels

2020 ◽  
Vol 9 (2) ◽  
pp. 122-128 ◽  
Author(s):  
Lei Nie ◽  
Xingchen Li ◽  
Zheng Wang ◽  
Kehui Hu ◽  
Ruihua Cai ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Vinyl Alcohol ◽  
Biphasic Calcium Phosphate ◽  
Poly Vinyl Alcohol

scholarly journals In vitro and ex vivo hemocompatibility of off-the-shelf modified poly(vinyl alcohol) vascular grafts

2015 ◽  
Vol 25 ◽  
pp. 97-108 ◽  
Author(s):  
Marie F.A. Cutiongco ◽  
Deirdre E.J. Anderson ◽  
Monica T. Hinds ◽  
Evelyn K.F. Yim
Keyword(s):  
Vinyl Alcohol ◽  
Ex Vivo ◽  
Vascular Grafts ◽  
Poly Vinyl Alcohol

In Vitro Elution of Amikacin and Ticarcillin from a Resorbable, Self-Setting, Fiber Reinforced Calcium Phosphate Cement

2011 ◽  
Vol 40 (5) ◽  
pp. 563-570 ◽  
Author(s):  
Ashlee E. Watts ◽  
Alan J. Nixon ◽  
Mark G. Papich ◽  
Holly D. Sparks ◽  
Wayne S. Schwark
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Fiber Reinforced

scholarly journals Calcium phosphate cement reinforced with poly (vinyl alcohol) fibers: An experimental and numerical failure analysis

2021 ◽  
Vol 119 ◽  
pp. 458-471
Author(s):  
Ali Paknahad ◽  
Mohsen Goudarzi ◽  
Nathan W. Kucko ◽  
Sander C.G. Leeuwenburgh ◽  
Lambertus J. Sluys
Keyword(s):  
Calcium Phosphate ◽  
Failure Analysis ◽  
Calcium Phosphate Cement ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol

scholarly journals Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery

2021 ◽  
Vol 8 (8) ◽  
pp. 107
Author(s):  
Lilis Iskandar ◽  
Lucy DiSilvio ◽  
Jonathan Acheson ◽  
Sanjukta Deb
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Vinyl Alcohol ◽  
Maxillofacial Surgery ◽  
Bone Defects ◽  
Bone Tissue Regeneration ◽  
Poly Vinyl Alcohol ◽  
Oral And Maxillofacial Surgery

Despite considerable advances in biomaterials-based bone tissue engineering technologies, autografts remain the gold standard for rehabilitating critical-sized bone defects in the oral and maxillofacial (OMF) region. A majority of advanced synthetic bone substitutes (SBS’s) have not transcended the pre-clinical stage due to inferior clinical performance and translational barriers, which include low scalability, high cost, regulatory restrictions, limited advanced facilities and human resources. The aim of this study is to develop clinically viable alternatives to address the challenges of bone tissue regeneration in the OMF region by developing ‘dual network composites’ (DNC’s) of calcium metaphosphate (CMP)—poly(vinyl alcohol) (PVA)/alginate with osteogenic ions: calcium, zinc and strontium. To fabricate DNC’s, single network composites of PVA/CMP with 10% (w/v) gelatine particles as porogen were developed using two freeze–thawing cycles and subsequently interpenetrated by guluronate-dominant sodium alginate and chelated with calcium, zinc or strontium ions. Physicochemical, compressive, water uptake, thermal, morphological and in vitro biological properties of DNC’s were characterised. The results demonstrated elastic 3D porous scaffolds resembling a ‘spongy bone’ with fluid absorbing capacity, easily sculptable to fit anatomically complex bone defects, biocompatible and osteoconductive in vitro, thus yielding potentially clinically viable for SBS alternatives in OMF surgery.

scholarly journals Enhanced Osteogenesis of Dental Pulp Stem Cells In Vitro Induced by Chitosan–PEG-Incorporated Calcium Phosphate Cement

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2252
Author(s):  
Jae Eun Kim ◽  
Sangbae Park ◽  
Woong-Sup Lee ◽  
Jinsub Han ◽  
Jae Woon Lim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Calcium Phosphate ◽  
Zeta Potential ◽  
Mechanical Strength ◽  
Calcium Phosphate Cement ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Ion Trapping ◽  
Alizarin Red

The use of bone graft materials is required for the treatment of bone defects damaged beyond the critical defect; therefore, injectable calcium phosphate cement (CPC) is actively used after surgery. The application of various polymers to improve injectability, mechanical strength, and biological function of injection-type CPC is encouraged. We previously developed a chitosan–PEG conjugate (CS/PEG) by a sulfur (VI) fluoride exchange reaction, and the resulting chitosan derivative showed high solubility at a neutral pH. We have demonstrated the CPC incorporated with a poly (ethylene glycol) (PEG)-grafted chitosan (CS/PEG) and developed CS/PEG CPC. The characterization of CS/PEG CPC was conducted using Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). The initial properties of CS/PEG CPCs, such as the pH, porosity, mechanical strength, zeta potential, and in vitro biocompatibility using the WST-1 assay, were also investigated. Moreover, osteocompatibility of CS/PEG CPCs was carried out via Alizarin Red S staining, immunocytochemistry, and Western blot analysis. CS/PEG CPC has enhanced mechanical strength compared to CPC, and the cohesion test also demonstrated in vivo stability. Furthermore, we determined whether CS/PEG CPC is a suitable candidate for promoting the osteogenic ability of Dental Pulp Stem Cells (DPSC). The elution of CS/PEG CPC entraps more calcium ion than CPC, as confirmed through the zeta potential test. Accordingly, the ion trapping effect of CS/PEG is considered to have played a role in promoting osteogenic differentiation of DPSCs. The results strongly suggested that CS/PEG could be used as suitable additives for improving osteogenic induction of bone substitute materials.

scholarly journals Multifunctional Coatings for Robotic Implanted Device

2019 ◽  
Vol 20 (20) ◽  
pp. 5126 ◽  
Author(s):  
Caterina Cristallini ◽  
Serena Danti ◽  
Bahareh Azimi ◽  
Veronika Tempesti ◽  
Claudio Ricci ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Vinyl Alcohol ◽  
Soft Tissues ◽  
Functional Characterization ◽  
Titanium Substrate ◽  
Repair Process ◽  
Chemical Imaging ◽  
In Vitro Cytotoxicity ◽  
Poly Vinyl Alcohol

The objective of this study was the preparation and physico-chemical, mechanical, biological, and functional characterization of a multifunctional coating for an innovative, fully implantable device. The multifunctional coating was designed to have three fundamental properties: adhesion to device, close mechanical resemblance to human soft tissues, and control of the inflammatory response and tissue repair process. This aim was fulfilled by preparing a multilayered coating based on three components: a hydrophilic primer to allow device adhesion, a poly(vinyl alcohol) hydrogel layer to provide good mechanical compliance with the human tissue, and a layer of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers. The use of biopolymer fibers offered the potential for a long-term interface able to modulate the release of an anti-inflammatory drug (dexamethasone), thus contrasting acute and chronic inflammation response following device implantation. Two copolymers, poly(vinyl acetate-acrylic acid) and poly(vinyl alcohol-acrylic acid), were synthetized and characterized using thermal analysis (DSC, TGA), Fourier transform infrared spectroscopy (FT-IR chemical imaging), in vitro cell viability, and an adhesion test. The resulting hydrogels were biocompatible, biostable, mechanically compatible with soft tissues, and able to incorporate and release the drug. Finally, the multifunctional coating showed a good adhesion to titanium substrate, no in vitro cytotoxicity, and a prolonged and controlled drug release.

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