scholarly journals Biologically active Camellia oleifera protein nanoparticles for improving the tumor microenvironment and drug delivery

2020 ◽  
Vol 8 (14) ◽  
pp. 3907-3915
Author(s):  
Xiaoping Qian ◽  
Tinghui Shen ◽  
Xiaoke Zhang ◽  
Chongzhi Wang ◽  
Weibo Cai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Interstitial Fluid ◽  
Therapeutic Response ◽  
Fluid Pressure ◽  
Biologically Active ◽  
Camellia Oleifera ◽  
Solid Stress ◽  
Protein Nanoparticles ◽  
Tumor Interstitial Fluid

Biologically active Camellia oleifera protein nanoparticles can lower tumor interstitial fluid pressure and solid stress, improving the therapeutic response.

Decrease in tumor interstitial fluid pressure by pentoxifylline

1992 ◽  
Vol 24 ◽  
pp. 307 ◽  
Author(s):  
Intae Lee ◽  
Thomas Demhartner ◽  
Yves Boucher ◽  
Rakesh K. Jain
Keyword(s):  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Tumor Interstitial Fluid

Numerical simulation of the tumor interstitial fluid transport: Consideration of drug delivery mechanism

2015 ◽  
Vol 101 ◽  
pp. 62-71 ◽  
Author(s):  
Mohammad Charjouei Moghadam ◽  
Amin Deyranlou ◽  
Alireza Sharifi ◽  
Hamid Niazmand
Keyword(s):  
Numerical Simulation ◽  
Drug Delivery ◽  
Interstitial Fluid ◽  
Fluid Transport ◽  
Tumor Interstitial Fluid ◽  
Delivery Mechanism

scholarly journals The Solid Mechanics of Cancer and Strategies for Improved Therapy

2017 ◽  
Vol 139 (2) ◽  
Author(s):  
Triantafyllos Stylianopoulos
Keyword(s):  
Tumor Progression ◽  
Interstitial Fluid ◽  
Solid Mechanics ◽  
Fluid Pressure ◽  
Lymphatic Vessels ◽  
Chemotherapeutic Agents ◽  
Interstitial Fluid Pressure ◽  
Mathematical Framework ◽  
Solid Stress ◽  
Stress Levels

Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can regulate fluid stresses by compressing intratumoral blood and lymphatic vessels. Blood vessel compression reduces tumor perfusion, while compression of lymphatic vessels hinders the ability of the tumor to drain excessive fluid from its interstitial space contributing to the uniform elevation of the interstitial fluid pressure. Hypoperfusion and interstitial hypertension pose major barriers to the systemic administration of chemotherapeutic agents and nanomedicines to tumors, reducing treatment efficacies. Hypoperfusion can also create a hypoxic and acidic tumor microenvironment that promotes tumor progression and metastasis. Hence, alleviation of intratumoral solid stress levels can decompress tumor vessels and restore perfusion and interstitial fluid pressure. In this review, three major types of tissue level solid stresses involved in tumor growth, namely stress exerted externally on the tumor by the host tissue, swelling stress, and residual stress, are discussed separately and details are provided regarding their causes, magnitudes, and remedies. Subsequently, evidence of how stress-alleviating drugs could be used in combination with chemotherapy to improve treatment efficacy is presented, highlighting the potential of stress-alleviation strategies to enhance cancer therapy. Finally, a continuum-level, mathematical framework to incorporate these types of solid stress is outlined.

Lowering of tumor interstitial fluid pressure specifically augments efficacy of chemotherapy

2003 ◽  
Vol 17 (12) ◽  
pp. 1756-1758 ◽  
Author(s):  
Alexei V. Salnikov ◽  
Vegard V. Iversen ◽  
Markus Koisti ◽  
Christian Sundberg ◽  
Lars Johansson ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Tumor Interstitial Fluid

scholarly journals Estimation of Tumor Interstitial Fluid Pressure (TIFP) Noninvasively

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0140892 ◽  
Author(s):  
Long Jian Liu ◽  
Stephen L. Brown ◽  
James R. Ewing ◽  
Brigitte D. Ala ◽  
Kenneth M. Schneider ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Tumor Interstitial Fluid
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