Biomedical applications of methionine-based systems

2021 ◽  
Author(s):  
Jie Liu ◽  
Jun Huang ◽  
Peikun Xin ◽  
Guiting Liu ◽  
Jun Wu
Keyword(s):  
Liver Disease ◽  
Cancer Treatment ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Functional Modification ◽  
Disease Therapy ◽  
Derivatives Of

Spurred by the structure, metabolism, and derivatives of methionine, this review systematically summarizes its recent progress in functional modification, cancer treatment, liver disease therapy.

scholarly journals Strategies to Functionalize the Anionic Biopolymer Na-Alginate without Restricting Its Polyelectrolyte Properties

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 919 ◽  
Author(s):  
Luca Szabó ◽  
Sandrine Gerber-Lemaire ◽  
Christine Wandrey
Keyword(s):  
Biological Activity ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Analytical Techniques ◽  
Carboxyl Groups ◽  
Cross Linking ◽  
Special Focus ◽  
Hydrogel Formation ◽  
Alginate Hydrogels ◽  
Derivatives Of

The natural anionic polyelectrolyte alginate and its derivatives are of particular interest for pharmaceutical and biomedical applications. Most interesting for such applications are alginate hydrogels, which can be processed into various shapes, self-standing or at surfaces. Increasing efforts are underway to functionalize the alginate macromolecules prior to hydrogel formation in order to overcome the shortcomings of purely ionically cross-linked alginate hydrogels that are hindering the progress of several sophisticated biomedical applications. Particularly promising are derivatives of alginate, which allow simultaneous ionic and covalent cross-linking to improve the physical properties and add biological activity to the hydrogel. This review will report recent progress in alginate modification and functionalization with special focus on synthesis procedures, which completely conserve the ionic functionality of the carboxyl groups along the backbone. Recent advances in analytical techniques and instrumentation supported the goal-directed modification and functionalization.

MicroRNAs and chronic liver disease: recent progress

2010 ◽  
Vol 30 (8) ◽  
pp. 896-899
Author(s):  
Mi-die XU ◽  
Wei-qing LI ◽  
Hong-yu YU
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Recent Progress ◽  
Chronic Liver

Recent progress in carbon-dots-based nanozymes for chemosensing and biomedical applications

2021 ◽  
Author(s):  
Deming He ◽  
Minmin Yan ◽  
Pengjuan Sun ◽  
Yuanqiang Sun ◽  
Lingbo Qu ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Biomedical Applications ◽  
Recent Progress

Polydopamine antibacterial materials

2021 ◽  
Author(s):  
Yu Fu ◽  
Lei Yang ◽  
Jianhua Zhang ◽  
Junfei Hu ◽  
Gaigai Duan ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Recent Progress ◽  
Antibacterial Materials ◽  
Functional Features

This review focuses on the recent progress in polydopamine antibacterial materials, including their structural and functional features, preparation strategies, antibacterial mechanisms, and their biomedical applications.

scholarly journals Self-Supporting Hydrogels Based on Fmoc-Derivatized Cationic Hexapeptides for Potential Biomedical Applications

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 678
Author(s):  
Carlo Diaferia ◽  
Elisabetta Rosa ◽  
Enrico Gallo ◽  
Giovanni Smaldone ◽  
Mariano Stornaiuolo ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Supporting Cell ◽  
Diagnostic Tools ◽  
Cationic Peptides ◽  
Protecting Group ◽  
Synthetic Hydrogel ◽  
Acetyl Group ◽  
Biophysical Techniques ◽  
Fmoc Protecting Group ◽  
Derivatives Of

Peptide-based hydrogels (PHGs) are biocompatible materials suitable for biological, biomedical, and biotechnological applications, such as drug delivery and diagnostic tools for imaging. Recently, a novel class of synthetic hydrogel-forming amphiphilic cationic peptides (referred to as series K), containing an aliphatic region and a Lys residue, was proposed as a scaffold for bioprinting applications. Here, we report the synthesis of six analogues of the series K, in which the acetyl group at the N-terminus is replaced by aromatic portions, such as the Fmoc protecting group or the Fmoc-FF hydrogelator. The tendency of all peptides to self-assemble and to gel in aqueous solution was investigated using a set of biophysical techniques. The structural characterization pointed out that only the Fmoc-derivatives of series K keep their capability to gel. Among them, Fmoc-K3 hydrogel, which is the more rigid one (G’ = 2526 Pa), acts as potential material for tissue engineering, fully supporting cell adhesion, survival, and duplication. These results describe a gelification process, allowed only by the correct balancing among aggregation forces within the peptide sequences (e.g., van der Waals, hydrogen bonding, and π–π stacking).

Recent Progress in Mitochondria-Targeting-Based Nanotechnology for Cancer Treatment

Nanoscale ◽  
2021 ◽  
Author(s):  
Jingbo Qin ◽  
Ningqiang Gong ◽  
Zhihuan Liao ◽  
Shouwen Zhang ◽  
Peter S. Timashev ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Targeted Delivery ◽  
Recent Progress ◽  
Proliferation And Apoptosis ◽  
Cancerous Cells ◽  
Mitochondria Targeting

Mitochondria play critical roles in the regulation of the proliferation and apoptosis of cancerous cells. Nanosystems for targeted delivery of cargos to mitochondria for cancer treatment have attracted increasing attention...

scholarly journals Stimuli Responsive, Programmable DNA Nanodevices for Biomedical Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Udisha Singh ◽  
Vinod Morya ◽  
Bhaskar Datta ◽  
Chinmay Ghoroi ◽  
Dhiraj Bhatia
Keyword(s):  
Biomedical Applications ◽  
Recent Progress ◽  
Dna Nanotechnology ◽  
Research Area ◽  
Biological Applications ◽  
Stimuli Responsive ◽  
Future Prospects ◽  
Dna Structures ◽  
Challenges And Opportunities

Of the multiple areas of applications of DNA nanotechnology, stimuli-responsive nanodevices have emerged as an elite branch of research owing to the advantages of molecular programmability of DNA structures and stimuli-responsiveness of motifs and DNA itself. These classes of devices present multiples areas to explore for basic and applied science using dynamic DNA nanotechnology. Herein, we take the stake in the recent progress of this fast-growing sub-area of DNA nanotechnology. We discuss different stimuli, motifs, scaffolds, and mechanisms of stimuli-responsive behaviours of DNA nanodevices with appropriate examples. Similarly, we present a multitude of biological applications that have been explored using DNA nanodevices, such as biosensing, in vivo pH-mapping, drug delivery, and therapy. We conclude by discussing the challenges and opportunities as well as future prospects of this emerging research area within DNA nanotechnology.

Reactive Oxygen Species (ROS) and Liver Disease Therapy

2014 ◽  
pp. 1809-1838 ◽  
Author(s):  
Francesco Bellanti ◽  
Juan Sastre ◽  
Gaetano Serviddio
Keyword(s):  
Reactive Oxygen Species ◽  
Liver Disease ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Disease Therapy

Recent Progress in Biomedical Applications of Chitosan Derivatives as Gene Carrier

2021 ◽  
pp. 213-250
Author(s):  
Pu-Song Zhao ◽  
Yi Wang ◽  
Wenshuang Sun ◽  
Lian-Yu Qi ◽  
Li-Fan Hu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Recent Progress ◽  
Gene Carrier ◽  
Chitosan Derivatives
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