Doxorubicin-loaded fluorescent carbon dots with PEI passivation as a drug delivery system for cancer therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (33) ◽  
pp. 17222-17237
Author(s):  
Yu Hailing ◽  
Lv Xiufang ◽  
Wu Lili ◽  
Li Baoqiang ◽  
Huang Kaichen ◽  
...  

CD-PEI-mediated doxorubicin specifically targets HCC tumors, enabling real-time monitoring and therapeutic efficacy through growth inhibition and apoptosis induction.


RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.



2018 ◽  
Vol 51 (5) ◽  
pp. e12488 ◽  
Author(s):  
Tingting Kong ◽  
Liying Hao ◽  
Yuanyuan Wei ◽  
Xiaoxiao Cai ◽  
Bofeng Zhu


2016 ◽  
Vol 27 (1) ◽  
pp. 111-124 ◽  
Author(s):  
Vaibhavkumar N. Mehta ◽  
Shiva Shankaran Chettiar ◽  
Jigna R. Bhamore ◽  
Suresh Kumar Kailasa ◽  
Ramesh M. Patel


Luminescence ◽  
2020 ◽  
Vol 35 (6) ◽  
pp. 913-923 ◽  
Author(s):  
Titto Sunil John ◽  
Pradeep Kumar Yadav ◽  
Devendra Kumar ◽  
Sushil Kumar Singh ◽  
Syed Hadi Hasan






2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.



2016 ◽  
Vol 4 (13) ◽  
pp. 2253-2263 ◽  
Author(s):  
Mingxian Liu ◽  
Yanzhou Chang ◽  
Jing Yang ◽  
Yuanyuan You ◽  
Rui He ◽  
...  

A new HNTs-based drug delivery system to improve the bioavailability of curcumin for cancer therapy is proposed.



2020 ◽  
Vol Volume 15 ◽  
pp. 65-80 ◽  
Author(s):  
Chen Xu ◽  
Rijin Song ◽  
Pei Lu ◽  
Jianchun Chen ◽  
Yongqiang Zhou ◽  
...  


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