scholarly journals In situ fabrication of MS@MnO2 hybrid as nanozymes for enhancing ROS-mediated breast cancer therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (43) ◽  
pp. 22317-22329
Author(s):  
Xufeng Zhu ◽  
Yanan Liu ◽  
Guanglong Yuan ◽  
Xian Guo ◽  
Jieqiong Cen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Oxygen Species ◽  
Breast Cancer Therapy ◽  
Curative Effect ◽  
In Situ Fabrication ◽  
Anti Cancer ◽  
Tumor Specificity

The reactive oxygen species (ROS)-mediated anti-cancer therapy that shows the advantages of tumor specificity, high curative effect, and less toxic side-effects has powerful potential for cancer treatment.

Fenton-reaction-stimulative nanoparticles decorated with a reactive-oxygen-species (ROS)-responsive molecular switch for ROS amplification and triple negative breast cancer therapy

2019 ◽  
Vol 7 (45) ◽  
pp. 7141-7151
Author(s):  
Jun Zhang ◽  
Tiantian Zuo ◽  
Xiao Liang ◽  
Yingxin Xu ◽  
Yifan Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Triple Negative Breast Cancer ◽  
Fenton Reaction ◽  
Triple Negative ◽  
Molecular Switch ◽  
Oxygen Species ◽  
Breast Cancer Therapy

P@P/H NPs were rapidly disintegrated in response to ROS, and this further enhanced ROS level in tumor cells via the Fenton reaction.

EGFR-targeting PLGA-PEG nanoparticles as a curcumin delivery system for breast cancer therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (42) ◽  
pp. 16365-16374 ◽  
Author(s):  
Hua Jin ◽  
Jiang Pi ◽  
Yue Zhao ◽  
Jinhuan Jiang ◽  
Ting Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Delivery System ◽  
Breast Cancer Therapy ◽  
Targeted Nanoparticles ◽  
Naturally Occurring ◽  
Anti Cancer

The anti-cancer impact of naturally-occurring curcumin can be enhanced through its delivery bound to targeted nanoparticles.

scholarly journals Injectable Glycol Chitosan Hydrogel Containing Folic Acid-Functionalized Cyclodextrin-Paclitaxel Complex for Breast Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 317
Author(s):  
Hoon Hyun ◽  
Min Ho Park ◽  
Gayoung Jo ◽  
Bo Young Lee ◽  
Jae Won Choi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Animal Study ◽  
Drug Carrier ◽  
Breast Cancer Therapy ◽  
Glycol Chitosan ◽  
Anti Cancer ◽  
Histological Results ◽  
Clinical Potential

We prepared a drug carrier which consisted of injectable methacrylated glycol chitosan (MGC) hydrogel, and a conjugate of 6-monodeoxy-6-monoamino-β-cyclodextrin⋅hydrochloride (6-NH2-β-CD⋅HCl), polyethylene glycol (PEG), and folic acid (FA) for the local delivery and improved cellular uptake of paclitaxel (PTX) (MGC/CDPF-ic-PTX). CDPF refers to a conjugate of 6-NH2-β-CD⋅HCl, PEG, and FA. The anti-cancer effect was investigated using a xenograft mouse model. As controls, the animal study on MGC/PTX and MGC/CD-ic-PTX was performed. The swelling ratio of all samples was analyzed for 7 days, and it showed a gradual increase for 3 days and a maintained state afterward. From the release result, the MGC-based samples have an initial burst for 1 day and a sustained release for 7 days. Results of cytotoxicity and animal study showed the biocompatibility and superior anti-cancer effect of MGC/CDPF-ic-PTX against breast cancer. Furthermore, histological results showed the anti-cancer capacity of MGC/CDPF-ic-PTX against breast cancer. These findings suggest that MGC/CDPF-ic-PTX has clinical potential for breast cancer therapy.

CDK1 in Breast Cancer: Implications for Theranostic Potential

2020 ◽  
Vol 20 (7) ◽  
pp. 758-767 ◽  
Author(s):  
Sepideh Izadi ◽  
Afshin Nikkhoo ◽  
Mohammad Hojjat-Farsangi ◽  
Afshin Namdar ◽  
Gholamreza Azizi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Cancer Progression ◽  
Cell Cycle Progression ◽  
Cancer Therapeutics ◽  
Detection Methods ◽  
Breast Cancer Therapy ◽  
Promising Target ◽  
Anti Cancer

Breast cancer has been identified as one of the main cancer-related deaths among women during some last decades. Recent advances in the introduction of novel potent anti-cancer therapeutics in association with early detection methods led to a decrease in the mortality rate of breast cancer. However, the scenario of breast cancer is yet going on and further improvements in the current anti-cancer therapeutic approaches are needed. Several factors are present in the tumor microenvironment which help to cancer progression and suppression of anti-tumor responses. Targeting these cancer-promoting factors in the tumor microenvironment has been suggested as a potent immunotherapeutic approach for cancer therapy. Among the various tumorsupporting factors, Cyclin-Dependent Kinases (CDKs) are proposed as a novel promising target for cancer therapy. These factors in association with cyclins play a key role in cell cycle progression. Dysregulation of CDKs which leads to increased cell proliferation has been identified in various cancers, such as breast cancer. Accordingly, the development and use of CDK-inhibitors have been associated with encouraging results in the treatment of breast cancer. However, it is unknown that the inhibition of which CDK is the most effective strategy for breast cancer therapy. Since the selective blockage of CDK1 alone or in combination with other therapeutics has been associated with potent anti-cancer outcomes, it is suggested that CDK1 may be considered as the best CDK target for breast cancer therapy. In this review, we will discuss the role of CDK1 in breast cancer progression and treatment.

Photo-Reactive Oxygen Species Boosting Strategy by Employing Mitochondrial Targeting Zinc-Doped Magnetic Nanoparticles to Enhance Anti-Cancer Therapy

Nano LIFE ◽  
2019 ◽  
Vol 09 (01n02) ◽  
pp. 1940005
Author(s):  
Congyu Wu ◽  
Ying Li ◽  
Jingjing Wang ◽  
Mengwei Chen ◽  
Yajing Shen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Visible Region ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Mitochondrial Targeting ◽  
Intracellular Ros ◽  
Anti Cancer

The peroxidase-like functionality of iron oxide (IO) nanoparticles has attracted substantial attention in cancer treatment by reactive oxygen species (ROS) catalytic over-generation. However, the inefficient intracellular ROS generation still hurdles ready-to-use application of IO nanoparticles, attributing to the transient lifetime and limited diffusion distance of ROS. Indeed, excessive ROS generation in mitochondria is desirable to enhance cell death against cancer cells. In this study, we designed zinc-doped magnetic nanoparticles (MNPs) conjugated with triphenylphosphonium (TPP) for mitochondrial targeting. Moreover, the nanoparticles with high absorbance in visible region can catalyze ROS overproduction under visible light irradiation. Our platform provides a novel application of MNPs in targeted cancer therapy, which serves as a light-controlled switch to accelerate ROS generation and induce incremental cellular death.

Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual-modality selective cancer therapy

2019 ◽  
Vol 7 (13) ◽  
pp. 2190-2200 ◽  
Author(s):  
Tiantian Zhang ◽  
Yinping Li ◽  
Weiying Hong ◽  
Zhiyong Chen ◽  
Peng Peng ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Iron Oxide ◽  
Cancer Therapy ◽  
Glucose Oxidase ◽  
Reactive Oxygen Species Generation ◽  
Photothermal Effect ◽  
Ros Generation ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Anti Cancer

The combination of PTT and ROS generation results in selective anti-cancer effects.

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