Using design of experiment to obtain a systematic understanding of the effect of synthesis parameters on the properties of perovskite nanocrystals

Nanoparticles formed from lipids are currently applied successfully to deliver drugs. The particle size of the nanoparticle system is an essential characteristic to enhance the entrance of the drugs inside tissues and cells. Using design of experiment is appealing to find the specific conditions to optimize particle size of drug-loaded nanoparticles. Authors of this chapter applied a fractional factorial design of half fraction 24-1 with levels between continue factors, finding statistically significant differences for two factors such as concentrations of drugs and type of solvent where the organic phase is dissolved. This design shows the optimization of a formulation of capsaicin in solid lipid nanoparticles. The chapter also includes information on methods to prepare solid lipid nanoparticles (SLN), the variables involved, and a selection of studies about optimization of SLN formulations.

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3D-printed continuous flow reactor for high yield synthesis of CH3NH3PbX3 (X = Br, I) nanocrystals

Journal of Materials Chemistry C ◽

10.1039/c9tc02390a ◽

2019 ◽

Vol 7 (30) ◽

pp. 9167-9174 ◽

Cited By ~ 8

Author(s):

Chong Li ◽

Baojun Ding ◽

Lijing Zhang ◽

Kepeng Song ◽

Shengyang Tao

Keyword(s):

Continuous Flow ◽

Flow Reactor ◽

High Yield ◽

Perovskite Nanocrystals ◽

Continuous Flow Reactor ◽

Yield Production ◽

3D Printed ◽

High Yield Production

Continuous high yield production of perovskite nanocrystals using a 3D printed microreactor.

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Flow chemistry for process optimisation using design of experiments

Journal of Flow Chemistry ◽

10.1007/s41981-020-00135-0 ◽

2021 ◽

Vol 11 (1) ◽

pp. 75-86

Author(s):

Connor J. Taylor ◽

Alastair Baker ◽

Michael R. Chapman ◽

William R. Reynolds ◽

Katherine E. Jolley ◽

...

Keyword(s):

Design Of Experiments ◽

Learning Outcomes ◽

Flow Reactor ◽

Flow Chemistry ◽

Chemistry Laboratory ◽

Process Optimisation ◽

Series Of Experiments ◽

Organic Chemistry Laboratory ◽

Optimisation Techniques ◽

Simple Flow

AbstractImplementing statistical training into undergraduate or postgraduate chemistry courses can provide high-impact learning experiences for students. However, the opportunity to reinforce this training with a combined laboratory practical can significantly enhance learning outcomes by providing a practical bolstering of the concepts. This paper outlines a flow chemistry laboratory practical for integrating design of experiments optimisation techniques into an organic chemistry laboratory session in which students construct a simple flow reactor and perform a structured series of experiments followed by computational processing and analysis of the results.

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One-step Solvothermal Synthesis and Characterization of BaTiO3 Nanoparticles

MRS Proceedings ◽

10.1557/proc-878-y1.5 ◽

2005 ◽

Vol 878 ◽

Author(s):

Helen Reveron ◽

Cyril Aymonier ◽

Anne Loppinet-Serani ◽

Mario Maglione ◽

Catherine Elissalde ◽

...

Keyword(s):

Solvothermal Synthesis ◽

Flow Reactor ◽

Molar Ratio ◽

Continuous Flow Reactor ◽

Synthesis Parameters ◽

Powder Characteristics ◽

One Step ◽

Reactor Temperature ◽

Batio3 Nanoparticles

AbstractUsing a continuous-flow reactor, barium titanate (BaTiO3) nanoparticles have been successfully synthesized at temperatures ranging from 150 to 380°C and 16 MPa. Ba-Ti alkoxide solutions were used as precursors and water as reagent. The influence of synthesis parameters on the powder characteristics was investigated. Results showed that the purity, crystallinity and stoichiometry of the as-synthesized BaTiO3 powder depend mainly on the reactor temperature, quantity of water injected into the reactor and the Ba:Ti molar ratio of alkoxide solutions.

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Prototyping for Desirability by Design of Experiments: A Case Study of a Hardware Startup

Volume 7: 30th International Conference on Design Theory and Methodology ◽

10.1115/detc2018-86293 ◽

2018 ◽

Cited By ~ 2

Author(s):

Lasse Skovgaard Jensen ◽

Daniel Vorting ◽

Andreas Villadsen ◽

Lasse Hylleberg Mølleskov ◽

Ali Gürcan Özkil

Keyword(s):

Response Surface Methodology ◽

Product Development ◽

Design Of Experiments ◽

Statistical Model ◽

Design Of Experiment ◽

Design Parameters ◽

Early Stages ◽

Start Up ◽

Perceived Desirability

This paper presents a study on how prototyping and ‘Design of Experiments’ principles can be applied in the early stages of product development. It is explored how four design parameters affect the perceived desirability of a physical alarm device, in development by a small start-up company. By utilizing recent advancements in the tools and platforms, available for the fabrication of prototypes, a range of physical prototypes are made. These prototypes are used to conduct 44 user tests and the results were used to establish a statistical model based on the Response Surface Methodology. The results of the model are outlined, highlighting the primary drivers of product desirability, as well as exemplifying the dynamics among the explored desirability parameters. The statistical model is tested through an experiment, which verifies the model’s ability to prescribe the perceived desirability for specific prototypes of the alarm device. The study hereby presents promising results for incorporating Design of Experiment principles in early stages of product development, and the authors encourage further studies to be conducted.

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Design of Experiment for the Optimization of Pesticide Removal from Wastewater by Photo-Electrochemical Oxidation with TiO2 Nanotubes

Catalysts ◽

10.3390/catal10050512 ◽

2020 ◽

Vol 10 (5) ◽

pp. 512 ◽

Cited By ~ 2

Author(s):

Annalisa Vacca ◽

Laura Mais ◽

Michele Mascia ◽

Elisabetta Maria Usai ◽

Simonetta Palmas

Keyword(s):

Design Of Experiment ◽

Flow Reactor ◽

Removal Rate ◽

Cell Voltage ◽

Objective Functions ◽

Reaction Products ◽

Initial Concentration ◽

Simulated Solar Light ◽

Pesticide Removal ◽

Density Flow

The Design of Experiment (DoE) technique has been used to investigate the photo-electrochemical removal of diuron (DRN) from wastewater. The process is carried out in a photo-electrochemical flow reactor, in which titania nanotubular electrode is irradiated with a simulated solar light. Different operative conditions have been investigated, in a planned 23 full factorial design in which imposed current density, flow rate and initial concentration have been varied at two levels. The removal process of DRN was investigated in terms of specific removal rate (K) and cell voltage (E), which were assumed as objective functions: the results show that the applied current has a paramount effect on both of the objective functions. From the analyses of the intermediates, it appears that the investigated parameters may exert different effects on the distribution of the reaction products: the initial concentration of diuron and the electrode potential seem to play a more important role, in this case.

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Continuous low temperature synthesis of MAPbX3 perovskite nanocrystals in a flow reactor

Reaction Chemistry & Engineering ◽

10.1039/c8re00098k ◽

2018 ◽

Vol 3 (5) ◽

pp. 640-644 ◽

Cited By ~ 14

Author(s):

Xinxing Liang ◽

Robert W. Baker ◽

Kejun Wu ◽

Wentao Deng ◽

Dominic Ferdani ◽

...

Keyword(s):

Low Temperature ◽

Room Temperature ◽

Flow Reactor ◽

Low Temperature Synthesis ◽

Temperature Synthesis ◽

Perovskite Nanocrystals ◽

Simple Flow

Perovskite nanocrystals prepared at room temperature using a simple flow reactor.

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Optimizing the Size of Drug-Loaded Nanoparticles Using Design of Experiments

Research Anthology on Synthesis, Characterization, and Applications of Nanomaterials ◽

10.4018/978-1-7998-8591-7.ch015 ◽

2021 ◽

pp. 330-356

Author(s):

Paola Cervantes-Covarrubias ◽

Ayla Vea-Barragan ◽

Aracely Serrano-Medina ◽

Eugenia Gabriela Carrillo-Cedillo ◽

José Manuel Cornejo-Bravo

Keyword(s):

Particle Size ◽

Design Of Experiments ◽

Design Of Experiment ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Fractional Factorial ◽

Solid Lipid ◽

Two Factors ◽

Nanoparticle System ◽

Selection Of

Nanoparticles formed from lipids are currently applied successfully to deliver drugs. The particle size of the nanoparticle system is an essential characteristic to enhance the entrance of the drugs inside tissues and cells. Using design of experiment is appealing to find the specific conditions to optimize particle size of drug-loaded nanoparticles. Authors of this chapter applied a fractional factorial design of half fraction 24-1 with levels between continue factors, finding statistically significant differences for two factors such as concentrations of drugs and type of solvent where the organic phase is dissolved. This design shows the optimization of a formulation of capsaicin in solid lipid nanoparticles. The chapter also includes information on methods to prepare solid lipid nanoparticles (SLN), the variables involved, and a selection of studies about optimization of SLN formulations.

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An Overview of the Design of Experiment Workflow

Design of Experiments for Chemical, Pharmaceutical, Food, and Industrial Applications - Advances in Chemical and Materials Engineering ◽

10.4018/978-1-7998-1518-1.ch009 ◽

2020 ◽

pp. 204-217

Author(s):

Marco A. Miranda-Ackerman ◽

Alejandra García-Lechuga

Keyword(s):

Land Use ◽

Design Of Experiments ◽

Design Of Experiment ◽

Agricultural Practices ◽

General Outline ◽

Sustainable Food ◽

Global Trends ◽

Food Supply Chains ◽

Processing Plants ◽

A Current

Design of Experiments as a subfield of statistics has its origins trying to understand systems and making decisions. In the context of food supply chains where agricultural and farm systems, packaging and processing plants, cold chains and food logistics, product design, warehousing, retailing, among many other steps and actors, come together to produce safe, healthy, nutritious, reliable, affordable, and sustainable food products. At each stage, many problems have to be solved and decisions have to be made from agricultural practices, scheduling, land use, costing, and pricing, at the farm and orchard level. A general outline is presented on the general workflow; illustrated through examples and a current review of some of the applications of design of experiments in the context of food production help provide some directives and guidelines. Global trends and challenges that influence both the food industry and the practice of design of experiments are discussed.

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