Innate immune activation by conditioned medium of cancer cells following combined phototherapy with photosensitizer-loaded gold nanorods

2020 ◽  
Vol 8 (47) ◽  
pp. 10812-10824 ◽  
Author(s):  
Malvin Wei Cherng Kang ◽  
Haiyan Liu ◽  
James Chen Yong Kah
Keyword(s):  
Effective Treatment ◽  
Cancer Cells ◽  
Conditioned Medium ◽  
Gold Nanorods ◽  
Immune Activation ◽  
Innate Immune ◽  
Immune Protection ◽  
Adaptive Responses ◽  
Treatment Combination ◽  
Anti Cancer

Nanoparticle-based phototherapy has evolved to include immunotherapy as an effective treatment combination for cancers through inducing anti-cancer immune activation leading to downstream adaptive responses and immune protection.

scholarly journals Periodic-shRNA molecules are capable of gene silencing, cytotoxicity and innate immune activation in cancer cells

2015 ◽  
Vol 44 (2) ◽  
pp. 545-557 ◽  
Author(s):  
Kevin E. Shopsowitz ◽  
Connie Wu ◽  
Gina Liu ◽  
Erik C. Dreaden ◽  
Paula T. Hammond
Keyword(s):  
Gene Silencing ◽  
Cancer Cells ◽  
Immune Activation ◽  
Innate Immune ◽  
Innate Immune Activation

An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening

The Analyst ◽  
2017 ◽  
Vol 142 (19) ◽  
pp. 3579-3587 ◽  
Author(s):  
Jacky Fong-Chuen Loo ◽  
Chengbin Yang ◽  
Hing Lun Tsang ◽  
Pui Man Lau ◽  
Ken-Tye Yong ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Drug Screening ◽  
Rnase H ◽  
Cancer Drug ◽  
Next Generation ◽  
Anti Cancer ◽  
A Cell

We have developed a next generation aptamer-based bio-barcode (ABC) assay to detect cytochrome-c (Cyto-c), a cell death marker released from cancer cells, for anti-cancer drug screening.

Cancer Treatment with Liposomes Based Drugs and Genes Co-delivery Systems

2018 ◽  
Vol 25 (28) ◽  
pp. 3319-3332 ◽  
Author(s):  
Chuanmin Zhang ◽  
Shubiao Zhang ◽  
Defu Zhi ◽  
Jingnan Cui
Keyword(s):  
Cell Cycle ◽  
Cancer Cells ◽  
Synergistic Effects ◽  
Resistance Mechanisms ◽  
Delivery Systems ◽  
Cell Cycle Checkpoints ◽  
Drug Efflux ◽  
Cancer Resistance ◽  
Cancer Models ◽  
Anti Cancer

There are several mechanisms by which cancer cells develop resistance to treatments, including increasing anti-apoptosis, increasing drug efflux, inducing angiogenesis, enhancing DNA repair and altering cell cycle checkpoints. The drugs are hard to reach curative effects due to these resistance mechanisms. It has been suggested that liposomes based co-delivery systems, which can deliver drugs and genes to the same tumor cells and exhibit synergistic anti-cancer effects, could be used to overcome the resistance of cancer cells. As the co-delivery systems could simultaneously block two or more pathways, this might promote the death of cancer cells by sensitizing cells to death stimuli. This article provides a brief review on the liposomes based co-delivery systems to overcome cancer resistance by the synergistic effects of drugs and genes. Particularly, the synergistic effects of combinatorial anticancer drugs and genes in various cancer models employing multifunctional liposomes based co-delivery systems have been discussed. This review also gives new insights into the challenges of liposomes based co-delivery systems in the field of cancer therapy, by which we hope to provide some suggestions on the development of liposomes based co-delivery systems.

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