Nanoscale photosensitizer with tumor-selective turn-on fluorescence and activatable photodynamic therapy treatment for COX-2 overexpressed cancer cells

2021 ◽  
Author(s):  
Lan Wang ◽  
Yuhuan Zhang ◽  
Ying Han ◽  
Qi Zhang ◽  
Zhenfu Wen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Single Molecule ◽  
Near Infrared ◽  
Turn On ◽  
Nir Fluorescence ◽  
Cox 2 ◽  
And Function ◽  
Therapy Treatment ◽  
Tumor Selective

A single molecule IMC-DAH-SQ can selectively recognize tumor cells with turn-on near infrared (NIR) fluorescence and function as an adaptive photosensitizer with photodynamic therapy activity.

scholarly journals Near-Infrared Fluorescence Imaging and Photodynamic Therapy for Liver Tumors

2021 ◽  
Vol 11 ◽  
Author(s):  
Masaki Kaibori ◽  
Hisashi Kosaka ◽  
Kosuke Matsui ◽  
Morihiko Ishizaki ◽  
Hideyuki Matsushima ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Liver Tumors ◽  
Nir Fluorescence ◽  
Recent Developments ◽  
Fluorescent Agent ◽  
Stable Particles ◽  
And Function ◽  
Cancer Tissues

Surgery with fluorescence equipment has improved to treat the malignant viscera, including hepatobiliary and pancreatic neoplasms. In both open and minimally invasive surgeries, optical imaging using near-infrared (NIR) fluorescence is used to assess anatomy and function in real time. Here, we review a variety of publications related to clinical applications of NIR fluorescence imaging in liver surgery. We have developed a novel nanoparticle (indocyanine green lactosome) that is biocompatible and can be used for imaging cancer tissues and also as a drug delivery system. To date, stable particles are formed in blood and have an ~10–20 h half-life. Particles labeled with a NIR fluorescent agent have been applied to cancer tissues by the enhanced permeability and retention effect in animals. Furthermore, this article reviews recent developments in photodynamic therapy with NIR fluorescence imaging, which may contribute and accelerate the innovative treatments for liver tumors.

Single-molecule chemiluminescent photosensitizer for a self-activating and tumor-selective photodynamic therapy of cancer

2019 ◽  
Vol 183 ◽  
pp. 111683 ◽  
Author(s):  
Luís Pinto da Silva ◽  
Ara Núnez-Montenegro ◽  
Carla M. Magalhães ◽  
Paulo J.O. Ferreira ◽  
Diana Duarte ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Single Molecule ◽  
Photodynamic Therapy Of Cancer ◽  
Tumor Selective

In-vitro efficacy of indocyanine green-mediated photodynamic therapy in combination with cisplatin or etoposide

2015 ◽  
Vol 4 (4) ◽  
Author(s):  
Kamola Kasimova ◽  
Lothar Lilge ◽  
Brian C. Wilson
Keyword(s):  
Photodynamic Therapy ◽  
Indocyanine Green ◽  
Tumor Cells ◽  
Near Infrared ◽  
Lung Tumor ◽  
Infrared Light ◽  
Cancer Therapies ◽  
Cytotoxic Effects ◽  
Limited Efficacy

Abstract:Localizing the cytotoxic effects of cancer therapies to only affect the tumor cells is a goal in oncology, to maximize efficacy and minimize treatment-related morbidities. Most effective chemotherapeutic drugs have significant side effects due to off-target toxicity. By comparison, photodynamic therapy (PDT) is a localized therapy without significant systemic toxicity but may have limited efficacy. Hence, combining PDT with chemotherapy was investigated to determine if the anti-tumor effect of the latter could be enhanced. PDT using indocyanine green (ICG), activated by near-infrared light, was investigated in lung tumor cells

Multifunctional magnetic nanoparticles for simultaneous cancer near-infrared imaging and targeting photodynamic therapy

RSC Advances ◽  
2014 ◽  
Vol 4 (107) ◽  
pp. 62153-62159 ◽  
Author(s):  
Xueling Zhao ◽  
Zongyan Chen ◽  
Hongli Zhao ◽  
Denghao Zhang ◽  
Liang Tao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Magnetic Nanoparticles ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Application ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Nir Fluorescence

In this work, a multifunctional drug delivery system was developed for potential application in NIR fluorescence imaging and targeting PDT.

scholarly journals A Near-Infrared, Wavelength-Shiftable, Turn-on Fluorescent Probe for the Detection and Imaging of Cancer Tumor Cells

2017 ◽  
Vol 12 (4) ◽  
pp. 1121-1132 ◽  
Author(s):  
Zhenhua Shen ◽  
Bijeta Prasai ◽  
Yuko Nakamura ◽  
Hisataka Kobayashi ◽  
Milcah S. Jackson ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Infrared Wavelength ◽  
Turn On ◽  
Cancer Tumor

Development of near-infrared photoactivable phthalocyanine-loaded nanoparticles to kill tumor cells: An improved tool for photodynamic therapy of solid cancers

2016 ◽  
Vol 12 (7) ◽  
pp. 1885-1897 ◽  
Author(s):  
Serena Duchi ◽  
Sara Ramos-Romero ◽  
Barbara Dozza ◽  
Marta Guerra-Rebollo ◽  
Luca Cattini ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Near Infrared

scholarly journals Mesoporous semiconductors combined with up-conversion nanoparticles for enhanced photodynamic therapy under near infrared light

RSC Advances ◽  
2019 ◽  
Vol 9 (30) ◽  
pp. 17273-17280 ◽  
Author(s):  
Fan Yang ◽  
Jun Liu ◽  
Xue Jiang ◽  
Weiwei Wu ◽  
Zhenni Wang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Near Infrared ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Near Infrared Light

Photodynamic therapy (PDT) is a promising and effective method for tumor therapy that relies on the reactive oxygen species (ROS) produced by photosensitizers at specific wavelengths to inhibit tumor cells.

scholarly journals Spider Toxin Peptide-Induced NIR Gold Nanocluster Fabrication for GSH-Responsive Cancer Cell Imaging and Nuclei Translocation

2021 ◽  
Vol 9 ◽  
Author(s):  
Huaxin Tan ◽  
Sisi Liu ◽  
Yaolin He ◽  
Guofeng Cheng ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Near Infrared ◽  
Nuclear Targeting ◽  
Gold Nanocluster ◽  
Cancerous Cell ◽  
Nir Fluorescence ◽  
High Level ◽  
Induced Aggregation

Goldnanoclusters (GNCs) have become a promising nanomaterial for bioimaging because of their unique optical properties and biocompatibility. In this study, lycosin-I peptide, which possesses a highly selective anticancer activity by affecting the permeability of cancer cell membrane, was firstly modified for constructing fluorescent GNCs (LGNCs) for bioimaging of tumor cells. The obtained LGNCs exhibited strong near-infrared (NIR) fluorescence, which can be further enhanced by the peptide-induced aggregation and selectively stained three cancerous cell lines over normal cell lines with low intrinsic toxicity. After uptake by tumor cells, LGNC aggregates can be depolymerized into ultrasmall nanoclusters by high-level glutathione (GSH) and realize the nuclear targeting translocation. Collectively, our work suggests the potential of natural active biomolecules in designing NIR fluorescent GNCs for bioimaging.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

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