Rational design of stable heptamethine cyanines and development of a boimarker-activatable probe for detecting acute lung/kidney injury via NIR-II fluorescence imaging

The Analyst ◽

10.1039/d1an02183d ◽

2022 ◽

Author(s):

Juan Ouyang ◽

Lihe Sun ◽

Fang Zeng ◽

Shuizhu Wu

Keyword(s):

Fluorescence Imaging ◽

Rational Design ◽

Kidney Injury ◽

High Quality ◽

Enhanced Imaging ◽

Activatable Probe

Developing high-quality dyes to construct activatable probes for analyte sensing via NIR-II fluorescence is critical to attain enhanced imaging depths and resolution. Heptamethine-cyanines can serve this purpose; however, they usually...

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Renal Protection in Critically Ill Patients

Kidney Protection ◽

10.1093/med/9780190611620.003.0016 ◽

2019 ◽

pp. 163-174

Author(s):

Ryan W. Haines ◽

John R. Prowle

Keyword(s):

Chronic Kidney Disease ◽

Intensive Care Unit ◽

Kidney Injury ◽

Adverse Outcomes ◽

Renal Protection ◽

High Quality ◽

Hemodynamic Stability ◽

Secondary Sources ◽

Short And Long Term

Acute kidney injury complicates over 50% of critical care admissions and is associated with both increased short and long-term mortality and the development or acceleration of chronic kidney disease. While in certain settings, such as cardiac surgery, primary prevention of AKI is possible, in most cases AKI is present or evolving at intensive care unit admission and the main clinical focus is secondary prevention of further kidney injury. In the absence of evidence for specific AKI-targeted therapies, high quality supportive care to maximize hemodynamic stability and avoidance of secondary sources of kidney injury are the cornerstones of renal protection. Fluid overload is particularly associated with adverse outcomes in critical illness complicated by AKI. Continuous methods of renal replacement therapy may promote hemodynamic stability and have been associated with better longer term renal outcomes.

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Taxonomic synthesis of the eastern North American millipede genus Pseudopolydesmus (Diplopoda: Polydesmida: Polydesmidae), utilizing high-detail ultraviolet fluorescence imaging

Zoological Journal of the Linnean Society ◽

10.1093/zoolinnean/zlz020 ◽

2019 ◽

Vol 187 (1) ◽

pp. 117-142 ◽

Cited By ~ 1

Author(s):

Petra Sierwald ◽

Derek A Hennen ◽

Xavier J Zahnle ◽

Stephanie Ware ◽

Paul E Marek

Keyword(s):

Electron Microscopy ◽

Scanning Electron Microscopy ◽

Fluorescence Imaging ◽

North American ◽

Type Material ◽

High Quality ◽

Subjective Synonym ◽

Scanning Electron

Abstract The species of the eastern North American millipede genus Pseudopolydesmus are reviewed. Synonyms and comprehensive literature citations are provided for each of the eight recognized species. Diagnostic morphology of the genus, including clarification of male gonopod terminology, is reviewed and defined using scanning electron microscopy and high-quality macrophotographic images, including those in which ultraviolet fluorescence was induced to produce detailed images of morphological structures. Based on the examination of available type material, the following eight species are recognized: (1) Pseudopolydesmus erasus; (2) Pseudopolydesmus canadensis; (3) Pseudopolydesmus collinus; (4) Pseudopolydesmus pinetorum; (5) Pseudopolydesmus minor; (6) Pseudopolydesmus caddo; (7) Pseudopolydesmus paludicolus; and (8) Pseudopolydesmus serratus. The species names Polydesmus neoterus and Polydesmus euthetus are here placed as junior subjective synonyms of Ps. minor (both syn. nov.), and Polydesmus natchitoches is placed as a junior subjective synonym of Ps. pinetorum (syn. nov.).

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Rational Design and Synthesis of a Metalloproteinase-Activatable Probe for Dual-Modality Imaging of Metastatic Lymph Nodes in Vivo

The Journal of Organic Chemistry ◽

10.1021/acs.joc.9b00331 ◽

2019 ◽

Vol 84 (10) ◽

pp. 6126-6133 ◽

Cited By ~ 1

Author(s):

Ling Yin ◽

Hao Sun ◽

Meng Zhao ◽

Anna Wang ◽

Shanshan Qiu ◽

...

Keyword(s):

Lymph Nodes ◽

Rational Design ◽

Metastatic Lymph Nodes ◽

Dual Modality ◽

Design And Synthesis ◽

Metastatic Lymph ◽

Dual Modality Imaging ◽

Activatable Probe

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Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo

Protein Science ◽

10.1002/pro.2843 ◽

2015 ◽

Vol 25 (2) ◽

pp. 308-315 ◽

Cited By ~ 16

Author(s):

Dan Yu ◽

Zhiqiang Dong ◽

William Clay Gustafson ◽

Rubén Ruiz-González ◽

Luca Signor ◽

...

Keyword(s):

Fluorescence Imaging ◽

Rational Design ◽

Fluorescent Protein ◽

Red Fluorescent Protein

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Rational design of a NIR-II fluorescent nano-system with maximized fluorescence performance and applications

Materials Advances ◽

10.1039/d1ma00516b ◽

2021 ◽

Author(s):

Haoli Yu ◽

Yuesong Wang ◽

Yan Chen ◽

Min Ji

Keyword(s):

Fluorescence Imaging ◽

In Vivo Imaging ◽

Rational Design ◽

Near Infrared ◽

Nir Fluorescence

Purpose: Near-infrared (NIR) fluorescence imaging (FI) become a research hotspot in the field of in vivo imaging. Here, we intend to synthesize a NIR-II fluorescence nano-system with an excellent fluorescence...

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Two-photon fluorescence imaging of mitochondria viscosity with water-soluble pyridinium inner salts

New Journal of Chemistry ◽

10.1039/d1nj05020f ◽

2022 ◽

Author(s):

Bin Fang ◽

Beilin Zhang ◽

Rongxiu Zhai ◽

Limin Wang ◽

Yang Ding ◽

...

Keyword(s):

Fluorescence Imaging ◽

Rational Design ◽

Fluorescence Probe ◽

Water Soluble ◽

Biological Applications ◽

Two Photon ◽

Two Photon Fluorescence ◽

Photon Fluorescence

Rational design of mitochondrial viscosity probes with water-soluble two-photon (TP) fluorescence probe still remains a challenge in practical biological applications. Herein, three novel water-soluble TP active sulfosalt derivatives (Mito-Z, Mito-H,...

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