Tilapia skin peptides restore cyclophosphamide-induced premature ovarian failure via inhibiting oxidative stress and apoptosis in mice

2022 ◽  
Author(s):  
Yun-Tao Zhao ◽  
Haowen Yin ◽  
Chuanyin Hu ◽  
Jian Zeng ◽  
Xinyi Shi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Premature Ovarian Failure ◽  
Value Added ◽  
Oreochromis Mossambicus ◽  
Ovarian Failure ◽  
Protective Effects

Tilapia (Oreochromis mossambicus) skin high value-added compounds have not been fully utilized in tilapia processing. Here, the protective effects of tilapia skin peptides (TSP) on primary ovarian failure (POF) and...

scholarly journals Chromosomal abnormalities & oxidative stress in women with premature ovarian failure (POF)

2012 ◽  
Vol 135 (1) ◽  
pp. 92 ◽  
Author(s):  
Rima Dada ◽  
Dhananjay Pathak ◽  
Alka Kriplani ◽  
Manoj Kumar ◽  
Sundararajan Venkatesh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Premature Ovarian Failure ◽  
Chromosomal Abnormalities ◽  
Ovarian Failure

scholarly journals Chemoprotective effects of plasma derived from mice of different ages and genders on ovarian failure after cyclophosphamide treatment

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Soghra Bahmanpour ◽  
Eisa Moradiyan ◽  
Farzaneh Dehghani ◽  
Nehleh Zarei-fard
Keyword(s):  
Blood Plasma ◽  
Premature Ovarian Failure ◽  
Ovarian Tissue ◽  
Young Female ◽  
Ovarian Failure ◽  
Control Group ◽  
Protective Effects ◽  
Primordial Follicles ◽  
Chemotherapy Drugs ◽  
Different Ages

Abstract Background Premature ovarian failure is one of the major side effects of chemotherapy drugs. Blood plasma contains several factors that might lead to the repair of different tissues. Objective The chemoprotective effects of plasma derived from mice with different ages and genders were assessed on ovarian tissue in cyclophosphamide-treated mice. Methods Forty-two adult female mice were divided into six groups as follows: (A) control; (B) 0.9% sodium chloride as vehicle; (C) cyclophosphamide; (D) cyclophosphamide + young male blood plasma; (E) cyclophosphamide + old male blood plasma; (F) cyclophosphamide + young female blood plasma. Ovarian failure was induced by injecting cyclophosphamide. On the 1st day, three groups received simultaneous injections of 150 μL intraperitoneal and 70 μL intravenous plasma derived from mice of different ages and genders. Each plasma type (150 μL) was then injected intraperitoneally every other 3 days for 19 days. On day 21, the dissected ovaries were stained for stereological analysis. Also, estrogen and progesterone levels were measured. Results Cyclophosphamide had damaging effects on ovarian parameters and led to reduced hormone levels in comparison with the control group. However, treating with young female and, old male blood plasma, to a lesser degree, showed beneficial effects on the number of primordial follicles, pre-antral follicles, and granulosa cells. Also, these two treatments had protective effects on the volume of ovarian parameters as well as estrogen and progesterone levels in comparison with the cyclophosphamide group (P < 0.05). Conclusion Plasma derived from mice of different ages and genders can ameliorate premature ovarian failure against the adverse effects of cyclophosphamide.

scholarly journals Curcumin exerts a protective effect against premature ovarian failure in mice

2018 ◽  
Vol 60 (3) ◽  
pp. 261-271 ◽  
Author(s):  
Zhengjie Yan ◽  
Youjin Dai ◽  
Heling Fu ◽  
Yuan Zheng ◽  
Dan Bao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Expression ◽  
Protective Effect ◽  
Premature Ovarian Failure ◽  
Ovarian Function ◽  
Ovarian Failure ◽  
Protective Agent ◽  
Primordial Follicles ◽  
Expression Levels ◽  
P16 Expression

This study was designed to investigate the protective effect of curcumin against d-galactose (d-gal)-induced premature ovarian failure (POF) in mice. A mouse POF model was induced by subcutaneous injection of d-gal (200 mg/kg/day) daily for 42 days. Mice in the curcumin group received both d-gal treatment and intraperitoneal injection of curcumin (100 mg/kg/day) for 42 days. Ovarian function, oxidative stress and apoptosis were evaluated. The P, E2 and SOD levels were higher, and the FSH, LH and MDA levels were significantly lower in the curcumin group than those in the d-gal group. The proportion of primordial follicles was also significantly higher in the curcumin group than that in the d-gal group. In addition, curcumin treatment after d-gal administration resulted in significantly lower Sod2, Cat, 8-OhdG, 4-HNE, NTY and senescence-associated protein P16 expression levels, higher Amh expression levels and less apoptosis in granulosa cells than was observed in the d-gal group. Moreover, the p-Akt, Nrf2 and HO-1 protein expression levels were significantly higher and the apoptosis-related cleaved caspase-3 and -9 protein expression levels were markedly lower in the curcumin group than in the d-gal group. In conclusion, curcumin effectively inhibited d-gal-induced oxidative stress, apoptosis and ovarian injury via a mechanism involving the Nrf2/HO-1 and PI3K/Akt signaling pathways, suggesting that curcumin is a potential protective agent against POF.

Role of Trace Elements, Oxidative Stress and Immune System: a Triad in Premature Ovarian Failure

2017 ◽  
Vol 184 (2) ◽  
pp. 325-333 ◽  
Author(s):  
Priyanka Verma ◽  
Aparna K Sharma ◽  
Hari Shankar ◽  
Alpana Sharma ◽  
D. N. Rao
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Immune System ◽  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
System A
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