Aptamer Selection against Alpha-defensin Human Neutrophil Peptide 1 on an Integrated Microfluidic System for Diagnosis of Periprosthetic Joint Infections

Lab on a Chip ◽  
2022 ◽  
Author(s):  
Rishabh Gandotra ◽  
Hung-Bin Wu ◽  
Priya Gopinathan ◽  
Yi-Cheng Tsai ◽  
Feng-Chih Kuo ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Microfluidic System ◽  
Joint Arthroplasty ◽  
Definite Diagnosis ◽  
Aptamer Selection ◽  
Microbiological Culture ◽  
Joint Infections ◽  
Human Neutrophil Peptide

Periprosthetic joint infections (PJI) arising from joint arthroplasty are dreadful, yet difficult to diagnose in subtle cases. Definite diagnosis requires microbiological culture to confirm the causative pathogens. However, up to...

scholarly journals Nonenzymatic Conversion of ADP-Ribosylated Arginines to Ornithine Alters the Biological Activities of Human Neutrophil Peptide-1

2014 ◽  
Vol 193 (12) ◽  
pp. 6144-6151 ◽  
Author(s):  
Linda A. Stevens ◽  
Joseph T. Barbieri ◽  
Grzegorz Piszczek ◽  
Amy N. Otuonye ◽  
Rodney L. Levine ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Biological Activities ◽  
Human Neutrophil Peptide

scholarly journals Therapeutic Potential of Human Neutrophil Peptide 1 against Experimental Tuberculosis

2001 ◽  
Vol 45 (2) ◽  
pp. 639-640 ◽  
Author(s):  
Sudhir Sharma ◽  
Indu Verma ◽  
G. K. Khuller
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Human Neutrophil ◽  
Therapeutic Efficacy ◽  
Therapeutic Potential ◽  
Therapeutic Activity ◽  
Experimental Tuberculosis ◽  
Dose Dependent ◽  
Different Doses ◽  
Human Neutrophil Peptide

ABSTRACT The therapeutic efficacy of human neutrophil peptide 1 (HNP-1) against experimental tuberculosis in mice on the basis of numbers of CFU has been examined. Mice infected with 1.5 × 104CFU of Mycobacterium tuberculosisH37Rv and treated with different doses of HNP-1 injected subcutaneously exhibited significant clearance of bacilli from lungs, livers, and spleens. There were time- and dose-dependent decreases in the bacillary load in lungs, livers, and spleens of the HNP-1-treated animals compared to that in controls (untreated animals). These observations strongly suggest the therapeutic activity of HNP-1 against tuberculosis.

What Is the Optimal Criteria to Use for Detecting Periprosthetic Joint Infections Before Total Joint Arthroplasty?

2018 ◽  
Vol 33 (7) ◽  
pp. S201-S204 ◽  
Author(s):  
Sumit Kanwar ◽  
Ahmed A. Al-Mansoori ◽  
Manisha R. Chand ◽  
Jesus M. Villa ◽  
Juan C. Suarez ◽  
...  
Keyword(s):  
Total Joint Arthroplasty ◽  
Joint Arthroplasty ◽  
Joint Infections

scholarly journals Application of leukocyte esterase strip test in the screening of periprosthetic joint infections and prospects of high-precision strips

Arthroplasty ◽  
2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Qing-Yuan Zheng ◽  
Guo-Qiang Zhang
Keyword(s):  
Diagnostic Criteria ◽  
New Technologies ◽  
Joint Infection ◽  
Diagnostic Techniques ◽  
Joint Arthroplasty ◽  
Quantitative Detection ◽  
Broad Application ◽  
Joint Infections ◽  
Strip Test ◽  
Machine Reading

Abstract Periprosthetic joint infection (PJI) represents one of the most challenging complications after total joint arthroplasty (TJA). Despite the availability of a variety of diagnostic techniques, the diagnosis of PJI remains a challenge due to the lack of well-established diagnostic criteria. The leucocyte esterase (LE) strips test has been proved to be a valuable diagnostic tool for PJI, and its weight in PJI diagnostic criteria has gradually increased. Characterized by its convenience, speed and immediacy, leucocyte esterase strips test has a prospect of broad application in PJI diagnosis. Admittedly, the leucocyte esterase strips test has some limitations, such as imprecision and liability to interference. Thanks to the application of new technologies, such as machine reading, quantitative detection and artificial intelligence, the LE strips test is expected to overcome the limitations and improve its accuracy.

scholarly journals Human neutrophil peptide-1 promotes alcohol-induced hepatic fibrosis and hepatocyte apoptosis

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0174913 ◽  
Author(s):  
Rie Ibusuki ◽  
Hirofumi Uto ◽  
Kohei Oda ◽  
Akihiko Ohshige ◽  
Kazuaki Tabu ◽  
...  
Keyword(s):  
Hepatic Fibrosis ◽  
Human Neutrophil ◽  
Hepatocyte Apoptosis ◽  
Human Neutrophil Peptide

scholarly journals Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

2015 ◽  
Vol 1853 (2) ◽  
pp. 308-316 ◽  
Author(s):  
Diana Gaspar ◽  
João M. Freire ◽  
Teresa R. Pacheco ◽  
João T. Barata ◽  
Miguel A.R.B. Castanho
Keyword(s):  
Human Neutrophil ◽  
Cellular Biomechanics ◽  
Anti Tumor Activity ◽  
Human Neutrophil Peptide

scholarly journals ADP-ribosyltransferase-specific Modification of Human Neutrophil Peptide-1

2006 ◽  
Vol 281 (25) ◽  
pp. 17054-17060 ◽  
Author(s):  
Gregorino Paone ◽  
Linda A. Stevens ◽  
Rodney L. Levine ◽  
Christelle Bourgeois ◽  
Wendy K. Steagall ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Specific Modification ◽  
Adp Ribosyltransferase ◽  
Human Neutrophil Peptide

Increased Risk of Periprosthetic Joint Infections in Patients With Hypothyroidism Undergoing Total Joint Arthroplasty

2016 ◽  
Vol 31 (4) ◽  
pp. 868-871 ◽  
Author(s):  
Timothy L. Tan ◽  
Haran Rajeswaran ◽  
Sleiman Haddad ◽  
Alisina Shahi ◽  
Javad Parvizi
Keyword(s):  
Total Joint Arthroplasty ◽  
Joint Arthroplasty ◽  
Joint Infections ◽  
Increased Risk
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