scholarly journals A 21st Century perspective on the contributions of Michaelis to enzyme kinetics

2012 ◽  
Vol 34 (2) ◽  
pp. 47-50
Author(s):  
Herbert Gutfreund

Leonor Michaelis (1875–1949) made some of the most important contributions to the application of physical chemistry to biological systems during the first half of the 20th Century. Like many young men interested in using basic physics and chemistry to study biomedical problems at that time, Michaelis was advised by no less a person than Paul Ehrlich to qualify in medicine to be able to earn a living. He followed that advice, and the work I am concerned with here was carried out after he completed his medical studies. For about 5 years before the outbreak of World War I, Michaelis's principal research interests centred on enzyme kinetics and the importance of hydrogen ions in biological systems. He carried out his basic research in clinical laboratories side by side with his medical work.

2021 ◽  
Vol 10 (2) ◽  
pp. 163-172
Author(s):  
P.P. SHCHERBININ ◽  
◽  
S.V. BUKALOVA ◽  

The article reconstructs the system of care for mental-ly ill war victims that developed in the Russian Empire during the World War I. It is shown that the system expanded its coverage from soldiers evacuated from the front to other categories of victims: refugees, garri-son soldiers, etc. The mechanism of interaction be-tween the Russian Red Cross Society, the Zemstvo Union and the Union of Cities, individual provincial zemstvos and city local self-governments, as well as a Special Commission of the Supreme Council for the support of families of persons called up for war, fami-lies of wounded and fallen soldiers in helping mentally ill victims of war is revealed. The main problematic and conflicting moments of this interaction are identified. Еstablished, that the need to provide psychiatric care to victims of war posed the tasks of fundamentally expanding the scale of psychiatric care in the Russian Empire. The article was carried out with the financial support of the Russian Foundation for Basic Research within the framework of the grant №19-09-00494.


2017 ◽  
Vol 12 (6) ◽  
pp. 987-998 ◽  
Author(s):  
Phillip L. Ackerman

Over 100 years have passed since Binet and Simon proposed scales for assessment of intelligence of children to predict academic success and failure. The extension of these assessments to adults largely resulted from efforts of psychologists to provide insights for military selection in World War I. At the time, relatively little thought was given to how adult intelligence might differ from child and adolescent intelligence. Traditional approaches for assessing adult intelligence have largely survived. However, there is little reference to adult intellectual functioning outside of laboratory-based tasks and clinical assessments of pathology. The result is that there are insufficient criterion measures for adult intelligence. Moreover, researchers have shifted from treating intelligence tests as predictors to treating them as criterion measures. The result is a disconnection between basic research on one hand and understanding adult intelligence on the other hand. This lack of connection is a serious impediment for predicting individual differences in performance on tasks which adults perform in their day-to-day work and nonwork lives. This article explores how the field has come to the current situation, and what remedies might be explored. Ultimately, a fundamental reexamination of how adult intelligence is studied and applied is suggested.


2020 ◽  
pp. 253-270
Author(s):  
D. V. Andriyanova ◽  
D. Yu. Fedotova

The article is devoted to the study of medical practice in Western Siberia of the late XIX - early XX centuries. Attention is paid to the organization of medical practice in the Tobolsk province. The quantitative and official composition of medical personnel is described. The relevance of the study is due to the fact that on the basis of a wide body of diverse material for the first time the experience of the activities and biographies of medical inspectors: N. A. Stroganov, F. K. Zembitsky, V. I. Nikitenko, M. V. Miloslavsky, G. N. Egorov is considered. Their role in the development of medical practice in the Tobolsk province of 1895-1917 is described. It is shown that these inspectors had a high level of education and extensive experience in medical work. It is pointed out that, despite all the efforts and significant success in the development of medical practice, there were objective difficulties in this field of activity, among which there was a shortage of personnel, funding, long distances between settlements, the Russian-Japanese War and World War I, etc. The authors use a representative base of both published sources and unpublished materials from the collections of the State Archives of Tobolsk.


2017 ◽  
pp. 142-155
Author(s):  
I. Rozinskiy ◽  
N. Rozinskaya

The article examines the socio-economic causes of the outcome of the Spanish Civil War (1936-1936), which, as opposed to the Russian Civil War, resulted in the victory of the “Whites”. Choice of Spain as the object of comparison with Russia is justified not only by similarity of civil wars occurred in the two countries in the XX century, but also by a large number of common features in their history. Based on statistical data on the changes in economic well-being of different strata of Spanish population during several decades before the civil war, the authors formulate the hypothesis according to which the increase of real incomes of Spaniards engaged in agriculture is “responsible” for their conservative political sympathies. As a result, contrary to the situation in Russia, where the peasantry did not support the Whites, in Spain the peasants’ position predetermined the outcome of the confrontation resulting in the victory of the Spanish analogue of the Whites. According to the authors, the possibility of stable increase of Spanish peasants’ incomes was caused by the nation’s non-involvement in World War I and also by more limited, compared to Russia and some other countries, spending on creation of heavy (primarily military-related) industry in Spain.


2016 ◽  
Vol 9 (1) ◽  
pp. 32-54 ◽  
Author(s):  
Jesse Tumblin

This article examines the way a group of colonies on the far reaches of British power – Australia, New Zealand, Canada, and India, dealt with the imperatives of their own security in the early twentieth century. Each of these evolved into Dominion status and then to sovereign statehood (India lastly and most thoroughly) over the first half of the twentieth century, and their sovereignties evolved amidst a number of related and often countervailing problems of self-defence and cooperative security strategy within the British Empire. The article examines how security – the abstracted political goods of military force – worked alongside race in the greater Pacific to build colonial sovereignties before the First World War. Its first section examines the internal-domestic dimension of sovereignty and its need to secure territory through the issue of imperial naval subsidies. A number of colonies paid subsidies to Britain to support the Royal Navy and thus to contribute in financial terms to their strategic defense. These subsidies provoked increasing opposition after the turn of the twentieth century, and the article exlpores why colonial actors of various types thought financial subsidies threatened their sovereignties in important ways. The second section of the article examines the external-diplomatic dimension of sovereignty by looking at the way colonial actors responded to the Anglo-Japanese Alliance. I argue that colonial actors deployed security as a logic that allowed them to pursue their own bids for sovereignty and autonomy, leverage racial discourses that shaped state-building projects, and ultimately to attempt to nudge the focus of the British Empire's grand strategy away from Europe and into Asia.


Author(s):  
Anthony Gorman

This chapter traces the development of the radical secular press in Egypt from its first brief emergence in the 1870s until the outbreak of World War I. First active in the 1860s, the anarchist movement gradually expanded its membership and influence over subsequent decades to articulate a general social emancipation and syndicalism for all workers in the country. In the decade and a half before 1914, its press collectively propagated a critique of state power and capitalism, called for social justice and the organisation of labour, and promoted the values of science and public education in both a local context and as part of an international movement. In seeking to promote a programme at odds with both nationalism and colonial rule, it incurred the hostility of the authorities in addition to facing the practical problems of managing and financing an oppositional newspaper.


Author(s):  
Odile Moreau

This chapter explores movement and circulation across the Mediterranean and seeks to contribute to a history of proto-nationalism in the Maghrib and the Middle East at a particular moment prior to World War I. The discussion is particularly concerned with the interface of two Mediterranean spaces: the Middle East (Egypt, Ottoman Empire) and North Africa (Morocco), where the latter is viewed as a case study where resistance movements sought external allies as a way of compensating for their internal weakness. Applying methods developed by Subaltern Studies, and linking macro-historical approaches, namely of a translocal movement in the Muslim Mediterranean, it explores how the Egypt-based society, al-Ittihad al-Maghribi, through its agent, Aref Taher, used the press as an instrument for political propaganda, promoting its Pan-Islamic programme and its goal of uniting North Africa.


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