scholarly journals Interactions of the 67 kDa laminin receptor and its precursor with laminin

2009 ◽  
Vol 30 (2) ◽  
pp. 73-79 ◽  
Author(s):  
Aliya Fatehullah ◽  
Caroline Doherty ◽  
Géraldine Pivato ◽  
George Allen ◽  
Lynda Devine ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Escherichia Coli ◽  
Heparan Sulfate ◽  
Human Breast Cancer ◽  
Biological Activities ◽  
Laminin Receptor ◽  
Human Breast ◽  
Surface Plasmon Resonance Experiment ◽  
Kinetics Of ◽  
Precise Molecular Mechanism

The 67LR (67 kDa laminin receptor) enables cells to interact with components of the extracellular matrix. The molecule is derived from the 37LRP (37 kDa laminin receptor precursor); however, the precise molecular mechanism of this conversion is unknown. Recombinant 37LRP, expressed in and purified from Escherichia coli, bound to human laminin in a SPR (surface plasmon resonance) experiment. 67LR isolated from human breast-cancer-derived cells in culture was also shown to bind to laminin by SPR. However, the kinetics of association are qualitatively different. 37LRP, but not 67LR, binds to heparan sulfate. The binding of 37LRP to heparan sulfate did not affect the interaction of 37LRP with laminin. In contrast, heparan sulfate reduces the extent of binding of laminin to 67LR. Taken together, these results show that 37LRP has some of the biological activities of 67LR, even prior to the conversion event. However, the conversion affects the sites of interaction with both laminin and heparan sulfate.

scholarly journals Effects of suramin on cell-cycle kinetics of MCF-7 human breast cancer cells in vitro

1993 ◽  
Vol 67 (2) ◽  
pp. 232-236 ◽  
Author(s):  
JA Foekens ◽  
AM Sieuwerts ◽  
EMJ Stuurman-Smeets ◽  
HA Peters ◽  
JGM Klijn
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cell Cycle Kinetics ◽  
Kinetics Of ◽  
Mcf 7

scholarly journals Heparan Sulfate Proteoglycans and Human Breast Cancer Epithelial Cell Tumorigenicity

2014 ◽  
Vol 115 (5) ◽  
pp. 967-976 ◽  
Author(s):  
Rachel K. Okolicsanyi ◽  
Andre J. van Wijnen ◽  
Simon M. Cool ◽  
Gary S. Stein ◽  
Lyn R. Griffiths ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Cell ◽  
Heparan Sulfate ◽  
Human Breast Cancer ◽  
Heparan Sulfate Proteoglycans ◽  
Human Breast ◽  
Breast Cancer Epithelial Cell

Effects of 1,25-dihydroxyvitamin D3 on cell-cycle kinetics of T 47D human breast cancer cells

1989 ◽  
Vol 138 (3) ◽  
pp. 611-616 ◽  
Author(s):  
John A. Eisman ◽  
Robert L. Sutherland ◽  
M. Lynne McMenemy ◽  
Jean-Charles Fragonas ◽  
Elizabeth A. Musgrove ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cell Cycle Kinetics ◽  
Dihydroxyvitamin D3 ◽  
Kinetics Of

scholarly journals EVALUATION OF ANTIBACTERIAL, ANTIOXIDANT, AND ANTICANCER POTENTIALS FROM MARINE RED ALGAE GRACILARIA CORTICATA

2018 ◽  
Vol 11 (8) ◽  
pp. 347 ◽  
Author(s):  
Jayasree P ◽  
Thiruchelvi R ◽  
Balashanmugam P
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Red Algae ◽  
Human Breast Cancer ◽  
Pathogenic Bacteria ◽  
Biological Activities ◽  
Diffusion Method ◽  
Human Breast ◽  
Gracilaria Corticata ◽  
Biological Potential

Objective: The present study was to evaluate the biological activity of Red algae, Gracilaria corticata, collected from the southeast coast of Mandapam, Ramanathapuram, Tamil Nadu. Seaweeds are rich in bioactive compounds. Seaweeds are highly diverse group of organism from secondary metabolites of the natural source are a potential source. The marine seaweed is the interesting group of their broad spectrum of biological activities such as antibacterial, antioxidant, and anticancer.Methods: The antibacterial activity of G. corticata was tested against Staphylococcus aureus and Escherichia coli by disk diffusion method. In vitro antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assay was employed to study the anticancer activity against (MDA-MB 231) human breast cancer cell line.Results: The DPPH assay screening of methanolic extract of G. corticata showed specific activity of inhibition. In antibacterial shows the growth of two virulent strains of pathogenic bacteria, E. coli and Bacillus subtilis. In anticancer activity obtained results indicated that the methanol extracts of G. corticata were cytotoxic against (MDA-MB231) human breast cancer cell.Conclusion: These results show that G. corticata has a great biological potential, which could be considered for future uses in pharmaceutical, food, and cosmetics purpose.

scholarly journals Oligosaccharide Sequence of Human Breast Cancer Cell Heparan Sulfate with High Affinity for Laminin

1998 ◽  
Vol 273 (33) ◽  
pp. 21111-21114 ◽  
Author(s):  
Narayanan Parthasarathy ◽  
Lisa F. Gotow ◽  
James D. Bottoms ◽  
Timothy E. Kute ◽  
William D. Wagner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Heparan Sulfate ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Human Breast Cancer ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
High Affinity
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