Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population

Abstract The levels of cytokines, inflammatory cells, and angiogenic factors increase following diabetic retinopathy (DR), and the association between interleukin-10 (IL-10) gene rs1800896 polymorphism (IL-10 -1082G/A polymorphism) and DR in different populations has been extensively studied. However, the findings are conflicting, and there is no relevant research in Chinese subjects. Therefore, this case–control study involving 327 cases (type 2 diabetes patients with proliferative DR (PDR)) and 461 controls (type 2 diabetes patients without DR) was conducted to address the relationship between IL-10 gene rs1800896 polymorphism and risk of PDR in Chinese population. Genotyping was performed using PCR-based restriction fragment length polymorphism (PCR-RFLP) assay. It was found that GG genotype or G allele of the IL-10 gene rs1800896 polymorphism was associated with decreased risk for PDR. In conclusion, IL-10 gene rs1800896 polymorphism decreases the risk of PDR.

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Polymorphisms of interleukin-4, -10 and 12B genes and diabetic retinopathy

Open Life Sciences ◽

10.2478/s11535-011-0036-6 ◽

2011 ◽

Vol 6 (4) ◽

pp. 558-564 ◽

Cited By ~ 2

Author(s):

Ines Cilenšek ◽

Amela Hercegovac ◽

Jovana Starčević ◽

Katarina Vukojević ◽

Mirna Babić ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Retinopathy ◽

Inflammatory Cells ◽

Interleukin 10 ◽

Interleukin 4 ◽

Interleukin 12 ◽

Cross Sectional ◽

Increased Risk ◽

Promoter Gene

AbstractIn diabetic retinopathy (DR) and other angiogenesis-associated diseases, increased levels of cytokines, inflammatory cells, and angiogenic factors are present. We investigated the hypothesis that rs2243250 polymorphism of the interleukin 4 (IL-4) gene or rs1800896 polymorphism of the interleukin 10 (IL-10) gene, and rs3212227 polymorphism of the 3’ untranslated region (3’ UTR) of the interleukin-12 p40 gene (IL12B) may be associated with the development of proliferative diabetic retinopathy (PDR) in Caucasians with type 2 diabetes (DM2). This cross sectional case — control study included 189 patients with PDR and 187 patients with type 2 diabetes without PDR. Polymorphisms rs1800896 of the IL-10 gene, rs2243250 of the IL-4 gene, and rs3212227 of IL12B gene were analyzed by ARMS -PCR and RFLP -PCR methods. Multivariate analysis demonstrated the GG genotype of the rs1800896 polymorphism of the IL-10 gene to be associated with increased risk for PDR (OR=1.99; 95% CI=1.11–3.57; P=0.02), whereas the TT genotype of the rs2243250 polymorphism of the IL-4 gene and the AA genotype of the rs3212227 polymorphism of the IL-12 gene were not independent risk factors for PDR. Our findings suggest that the genetic variations at the IL-10 promoter gene might be a genetic risk factor for PDR in Caucasians with type 2 diabetes.

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Correction: Prevalence and Progression Rate of Diabetic Retinopathy in Type 2 Diabetes Patients in Correlation with the Duration of Diabetes

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-0757-3796 ◽

2018 ◽

Vol 126 (09) ◽

pp. e2-e2

Author(s):

Margarete Voigt ◽

Sebastian Schmidt ◽

Thomas Lehmann ◽

Benjamin Köhler ◽

Christof Kloos ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Retinopathy ◽

Progression Rate ◽

Duration Of Diabetes ◽

Diabetes Patients

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MON-187 The E23K Missense Variant of the Gene Encoding the Pancreatic Beta-Cell KATP Channel Subunit Kir6.2 (KCNJ11) Associates with Diabetic Retinopathy and Hyperglycemia Control in Type 2 Diabetes Patients

Journal of the Endocrine Society ◽

10.1210/js.2019-mon-187 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Sameh Sarray ◽

Wassim Almawi

Keyword(s):

Type 2 Diabetes ◽

Diabetic Retinopathy ◽

Beta Cell ◽

Katp Channel ◽

Pancreatic Beta Cell ◽

Missense Variant ◽

Gene Encoding ◽

Diabetes Patients

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The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy

Journal of Ophthalmology ◽

10.1155/2018/2439691 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Azusa Ito ◽

Hiroshi Kunikata ◽

Masayuki Yasuda ◽

Shojiro Sawada ◽

Keiichi Kondo ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Retinopathy ◽

Conduction Velocity ◽

Nerve Conduction ◽

Nerve Conduction Velocity ◽

Neuronal Damage ◽

Intima Media Thickness ◽

Clinical Findings ◽

Diabetes Patients

Purpose. Nerve conduction velocity (NCV) is an indicator of neuronal damage in the distal segment of the peripheral nerves. Here, we determined the association between NCV and other systemic and ocular clinical findings, in type 2 diabetes patients with early diabetic retinopathy (DR). Methods. This study included 42 eyes of 42 type 2 diabetes patients (median age: 54 years) with no DR or with mild nonproliferative DR. Standard statistical techniques were used to determine associations between clinical findings. Results. Sural sensory conduction velocity (SCV) and tibial motor conduction velocity (MCV) were significantly lower in mild nonproliferative DR patients than patients with no DR (P=0.008 and P=0.01, resp.). Furthermore, logistic regression analyses revealed that sural SCV and tibial MCV were independent factors contributing to the presence of mild nonproliferative DR (OR 0.83, P=0.012 and OR 0.69 P=0.02, resp.). Tibial MCV was correlated with choroidal thickness (CT) (P=0.01), and a multiple regression analysis revealed that age, tibial MCV, and carotid intima-media thickness were independent associating factors with CT (P=0.035, P=0.015, and P=0.008, resp.). Conclusions. Our findings suggest that reduced NCV may be closely associated with early DR in type 2 diabetes patients. Thus, reduced nerve conduction is a potential early biomarker of DR.

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