Free radical scavenging: a potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors
1990 ◽
Vol 18
(6)
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pp. 1184-1185
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Keyword(s):
Summary Free radical (FR) scavenging may be a therapeutically useful adjunctive property of angiotensin converting enzyme (ACE) inhibitors. In this study we have shown that SH-containing ACE inhibitors (captopril, epicaptopril, zofenopril) are potent FR scavengers at a concentration of 4 × 10-5m whereas non-SH ACE inhibitors (enalaprilat, quinaprilat and perindoprilat) have no FR-scavenging activity at this concentration. Furthermore, the SH-containing agents preferentially scavenged general radicals rather than superoxide radicals, i.e. suggesting that these drugs would be effective in quenching the culprit FR in ischaemia/reperfusion injury.
2021 ◽
Vol 10
(1)
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1990 ◽
Vol 40
(9)
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pp. 2169-2175
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2019 ◽
Vol 7
(4)
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2019 ◽
pp. 1-7
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2013 ◽
Vol 12
(1)
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pp. 80-87
2020 ◽
Vol 65
(4)
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pp. 149-153
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1988 ◽
Vol 33
(2)
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pp. 247-248
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