Glycogen synthase kinase-3β in SHSY-5Y cell line is induced by cAMP-dependent protein kinase(PKA) pathway

2000 ◽  
Vol 28 (5) ◽  
pp. A305-A305
Author(s):  
W. C. Lee ◽  
C. C. J. Miller ◽  
P. C. Shaw
Keyword(s):  
Protein Kinase ◽  
Cell Line ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Pka Pathway

scholarly journals Integrin-Linked Kinase Is a Functional Mn2+-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. e12356 ◽  
Author(s):  
Mykola Maydan ◽  
Paul C. McDonald ◽  
Jasbinder Sanghera ◽  
Jun Yan ◽  
Charalampos Rallis ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Integrin Linked Kinase ◽  
Gsk 3Β

Chaperones, somatotroph tumors and the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway

2020 ◽  
Vol 499 ◽  
pp. 110607 ◽  
Author(s):  
Marie Helene Schernthaner-Reiter ◽  
Giampaolo Trivellin ◽  
Constantine A. Stratakis
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Pka Pathway

cAMP-dependent protein kinase regulates renal epithelial cell properties

1991 ◽  
Vol 260 (6) ◽  
pp. C1290-C1299 ◽  
Author(s):  
K. Amsler ◽  
S. Ghatani ◽  
B. A. Hemmings
Keyword(s):  
Protein Kinase ◽  
Epithelial Cell ◽  
Cell Line ◽  
Cell Junctions ◽  
Kinetic Properties ◽  
Wild Type ◽  
Dependent Protein Kinase ◽  
Renal Epithelial Cell ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein

Previous studies have implicated adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase (PKA) in regulation of both growth and expression of differentiated function in the pig renal epithelial cell, LLC-PK1. To investigate this possible regulatory mechanism, we compared growth behavior, morphology, and appearance of two differentiated functions, Na-hexose symport (SYMP) and gamma-glutamyl transpeptidase (gamma-GT), in the LLC-PK1 line and two PKA-deficient mutants (FIB4 and FIB6). Compared with the wild-type cell line, the mutant lines continued to proliferate at higher population densities and exhibited altered cell morphology, poorer formation of the brush-border structure, and decreased or lack of expression of SYMP and gamma-GT activities. Wild-type and mutant cells exhibit an identical logarithmic growth rate. Both lines form cell-cell junctions and exhibit identical kinetic properties of expressed SYMP activity. These results strongly support the hypothesis that PKA modulates a defined subset of cellular processes, including aspects of growth control and expression of the differentiated phenotype, in this renal epithelial cell line.

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