Molecular probes: insights into design and analysis from computational and physical chemistry
2008 ◽
Vol 36
(1)
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pp. 46-50
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Keyword(s):
The application of new molecular diagnostics to probe cellular process in vivo is leading to a greater understanding of molecular cytology at a sub-nanoscale level and is opening the way to individualized medicines. We review here three distinct fluorescence-based molecular probes, HyBeacons™, split-probe exciplexes and GFP (green fluorescent protein)-based FRET (fluorescence resonance energy transfer) systems. Through this, we highlight the insights into the mechanism and design that a combined computational and experimental approach can yield.
2005 ◽
Vol 330
(2)
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pp. 454-460
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2006 ◽
Vol 70
(8)
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pp. 1921-1927
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2008 ◽
Vol 75
(1)
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pp. 28-39
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2006 ◽
Vol 356
(1)
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pp. 108-116
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