Regulation of Breathing during Exercise in Normal Subjects and in Chronic Lung Disease

1976 ◽  
Vol 51 (6) ◽  
pp. 575-582 ◽  
Author(s):  
G. W. Bradley ◽  
R. Crawford
Keyword(s):  
Lung Disease ◽  
Chronic Lung Disease ◽  
Obstructive Lung Disease ◽  
Breathing Pattern ◽  
Normal Subjects ◽  
Men And Women ◽  
Restrictive Lung Disease ◽  
Regulation Of Breathing ◽  
Normal Women ◽  
Normal Men

1. The breathing pattern in normal subjects during exercise was compared with that in patients with obstructive and restrictive lung defects. 2. In most normal women and patients with obstructive or restrictive lung disease, as the frequency of breathing increased both inspiratory and expiratory duration fell. However, in most normal men (74%) inspiratory duration did not fall as ventilation increased. 3. Women breathed faster than men, and both obstructed and restricted patients breathed faster than normal subjects. 4. The airflow patterns in normal men and women were similar, but most patients with restrictive or obstructive lung disease showed an approximately exponential fall in flow during expiration.

Stress Reactions Resulting from the Relocation of an aged Population

1968 ◽  
Vol 13 (3) ◽  
pp. 201-209 ◽  
Author(s):  
V. A. Kral ◽  
B. Grad ◽  
J. Berenson
Keyword(s):  
Respiratory Infections ◽  
Normal Subjects ◽  
Lower Number ◽  
The Body ◽  
Stress Reactions ◽  
Men And Women ◽  
Relative Percentage ◽  
Significant Difference ◽  
Normal Women ◽  
Normal Men

Fifty-four subjects from 64 to 94 years of age were investigated for their stress reactions following their relocation from one site to another. Forty of them, 16 men and 24 women, were psychiatrically normal, while the remainder (eight men and six women) were suffering from a psychosis, which in all cases, except one, was of organic type. There was no statistically significant difference between the ages of the men and women, and of the normals and psychotics. The same was true in the case of the body weight, except that the men weighed more than the women. Plasma corticoid (PC) levels were determined two to nine days before relocation and eight to 17 days afterwards. One-third of the subjects made no complaints in regard to their health within four months of relocation (NC 33%), while the rest either reported symptoms for which there did not appear to be any apparent organic cause (WS 43%) or presented organic signs (OS 24%). Most of the complaints in the WS category were related to the abdomen, while most of those in the OS group were either due to respiratory infections or cardiovascular conditions. The relative percentage of persons falling into these three categories was essentially similar in normal men and in normal women and in psychotic men and psychotic women. However, the psychotics had a significantly higher incidence of OS persons and a significantly lower number of NC subjects than did the normals, while the incidence of WS was essentially the same in these two groups. Following relocation the PC levels increased in normal men, but decreased in normal women. Furthermore, a greater PC increase was observed in men of the OS group than in those of the WS category, who in turn showed a greater increase than the NC males. This was not observed in the women. Men in each of the NC, WS and OS categories had higher PC levels than women of the same category, and psychotics higher than normals. Twenty-five per cent of the normal men died within the first six months of relocation but none of the normal women, a statistically significant difference. Within 23 months of relocation reliably more psychotics died than normals. In conclusion, normal aged men appeared to suffer more from the relocation than normal aged women, and psychotic aged persons more than psychiatrically normal subjects of the same age.

Hysterical traits and variability of mood in normal men

1979 ◽  
Vol 9 (2) ◽  
pp. 301-304 ◽  
Author(s):  
Peter V. Rabins ◽  
Phillip R. Slavney
Keyword(s):  
Men And Women ◽  
Normal Women ◽  
Normal Men

SynopsisIn a study of 40 normal men it was found that self-ratings on variability of mood were positively correlated with self-ratings on hysterical traits. These results are similar to those found in normal women and lend support both to the validity of the concept of hysterical personality and to the idea that men and women experience fluctuations of mood in a similar way.

Effort sensation, chemoresponsiveness, and breathing pattern during inspiratory resistive loading

1992 ◽  
Vol 73 (2) ◽  
pp. 440-445 ◽  
Author(s):  
J. E. Clague ◽  
J. Carter ◽  
M. G. Pearson ◽  
P. M. Calverley
Keyword(s):  
Tidal Volume ◽  
Breathing Pattern ◽  
Free Breathing ◽  
Normal Subjects ◽  
Inspiratory Effort ◽  
Sustained Load ◽  
Resistive Loading ◽  
End Tidal ◽  
Few Data ◽  
Normal Men

Although inspiratory resistive loading (IRL) reduces the ventilatory response to CO2 (VE/PCO2) and increases the sensation of inspiratory effort (IES), there are few data about the converse situation: whether CO2 responsiveness influences sustained load compensation and whether awareness of respiratory effort modifies this behavior. We studied 12 normal men during CO2 rebreathing while free breathing and with a 10-cmH2O.l-1.s IRL and compared these data with 5 min of resting breathing with and without the IRL. Breathing pattern, end-tidal PCO2, IES, and mouth occlusion pressure (P0.1) were recorded. Free-breathing VE/PCO2 was inversely related to an index of effort perception (IES/VE; r = -0.63, P less than 0.05), and the reduction in VE/PCO2 produced by IRL was related to the initial free-breathing VE/PCO2 (r = 0.87, P less than 0.01). IRL produced variable increases in inspiratory duration (TI), IES, and P0.1 at rest, and the change in tidal volume correlated with both VE/PCO2 (r = 0.63, P less than 0.05) and IES/VE (r = -0.69, P less than 0.05), this latter index also predicting the changes in TI with loading (r = -0.83, P less than 0.01). These data suggest that in normal subjects perception of inspiratory effort can modify free-breathing CO2 responsiveness and is as important as CO2 sensitivity in determining the response to short-term resistive loading. Individuals with good perception choose a small-tidal volume and short-TI breathing pattern during loading, possibly to minimize the discomfort of breathing.

Differential effects of a dopaminergic drug (piribedil) on pituitary hormone release in normal men and women

1983 ◽  
Vol 104 (4) ◽  
pp. 385-389 ◽  
Author(s):  
Laura De Marinis ◽  
Antonio Mancini ◽  
Francesco Calabrò ◽  
Michele Massari ◽  
Massimo Torlontano ◽  
...  
Keyword(s):  
Dopamine Receptor Agonist ◽  
Pituitary Hormone ◽  
Hormone Release ◽  
Men And Women ◽  
Differential Effects ◽  
Anterior Pituitary Hormone ◽  
Sexual Steroid ◽  
Dopaminergic Tone ◽  
Normal Women ◽  
Normal Men

Abstract. Six normal women, in the follicular phase of their menstrual cycle, and 6 normal men received orally 40, 60 and 100 mg doses of piribedil, a dopamine receptor agonist, or placebo. The effects of piribedil on anterior pituitary hormone release was evaluated. In normal women a dose-related decrease in Prl levels was observed, while in men the Prl decrement was not related to the dose employed. In women an increase in serum hGH occurred after administration of the lowest (40 mg) dose of piribedil. In normal men, on the contrary, a modest hGH stimulation was present after administration of all doses of the drug. No consistent changes in serum TSH, LH and FSH concentrations were observed and no side effects were reported. The results from this study indicate that piribedil can exert differential effects on hypophyseal trophic hormone release and that these effects are sex-related. It is possible that the differences observed in men and women after the administration of piribedil are due to a different endogenous dopaminergic tone, induced by the different sexual steroid environment.

scholarly journals Sex differences in proximal and distal nephron function contribute to the mechanism of idiopathic hypercalcuria in calcium stone formers

2015 ◽  
Vol 309 (1) ◽  
pp. R85-R92 ◽  
Author(s):  
Benjamin Ko ◽  
Kristin Bergsland ◽  
Daniel L. Gillen ◽  
Andrew P. Evan ◽  
Daniel L. Clark ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Distal Tubule ◽  
Normal Subjects ◽  
Idiopathic Hypercalciuria ◽  
Distal Nephron ◽  
Stone Formers ◽  
Calcium Reabsorption ◽  
Normal Women ◽  
Normal Males ◽  
Normal Men

Idiopathic hypercalciuria (IH) is a common familial trait among patients with calcium nephrolithiasis. Previously, we have demonstrated that hypercalciuria is primarily due to reduced renal proximal and distal tubule calcium reabsorption. Here, using measurements of the clearances of sodium, calcium, and endogenous lithium taken from the General Clinical Research Center, we test the hypothesis that patterns of segmental nephron tubule calcium reabsorption differ between the sexes in IH and normal subjects. When the sexes are compared, we reconfirm the reduced proximal and distal calcium reabsorption. In IH women, distal nephron calcium reabsorption is decreased compared to normal women. In IH men, proximal tubule calcium reabsorption falls significantly, with a more modest reduction in distal calcium reabsorption compared to normal men. Additionally, we demonstrate that male IH patients have lower systolic blood pressures than normal males. We conclude that women and men differ in the way they produce the hypercalciuria of IH, with females reducing distal reabsorption and males primarily reducing proximal tubule function.

scholarly journals Vitamin D Deficiency and Chronic Lung Disease

2009 ◽  
Vol 16 (3) ◽  
pp. 75-80 ◽  
Author(s):  
Christopher R Gilbert ◽  
Seth M Arum ◽  
Cecilia M Smith
Keyword(s):  
Vitamin D ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Vitamin D Deficiency ◽  
Chronic Lung Disease ◽  
Obstructive Lung Disease ◽  
Lung Diseases ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Chronic Lung Diseases

Vitamin D deficiency is increasingly being recognized as a prevalent problem in the general population. Patients with chronic lung diseases such as asthma, cystic fibrosis, chronic obstructive lung disease and interstitial pneumonia appear to be at increased risk for vitamin D deficiency for reasons that are not clear.Several studies indicate that vitamin D possesses a range of anti-inflammatory properties and may be involved in processes other than the previously believed functions of calcium and phosphate homeostasis. Various cytokines, cellular elements, oxidative stress and protease/antiprotease levels appear to affect lung fibroproliferation, remodelling and function, which may be influenced by vitamin D levels. Chronic lung diseases such as asthma and chronic obstructive lung disease have also been linked to vitamin D on a genetic basis. This immune and genetic influence of vitamin D may influence the pathogenesis of chronic lung diseases. A recent observational study notes a significant association between vitamin D deficiency and decreased pulmonary function tests in a large ambulatory population.The present review will examine the current literature regarding vitamin D deficiency, its prevalence in patients with chronic lung disease, vitamin D anti-inflammatory properties and the role of vitamin D in pulmonary function.

scholarly journals Association of Serum Ferritin Concentration and Lung Function in the Tobacco-naïve Population: Retrospective population-based study of KNHANES V

2019 ◽  
Author(s):  
Taeyun Kim ◽  
Hyunji Choi ◽  
Jihun Kang
Keyword(s):  
Lung Function ◽  
Lung Disease ◽  
Serum Ferritin ◽  
Obstructive Lung Disease ◽  
Regression Analyses ◽  
Ferritin Concentration ◽  
Restrictive Lung Disease ◽  
Increased Risk ◽  
Menopausal Women ◽  
Post Menopausal

Abstract Background: Ferritin regulates iron homeostasis, and is involved in the inflammation in the lung, especially in smokers; however, its effects on pulmonary function in non-smokers remain unclear. The present study aimed to evaluate the association between serum ferritin and lung function in a tobacco-naïve population. Methods: In this study, 25,534 individuals were enrolled, among who 5,338 tobacco-naïve individuals were identified; of those, 342 men and 2,879 women (742 pre- and 2,137 post-menopausal) with data of serum ferritin, lung function, and covariates were included. To evaluate the association of ferritin and lung function, multivariable-adjusted linear regression analyses was used including the factors of predicted value of forced expiratory volume in 1 second (FEV 1 %) and forced vital capacity (FVC%) . Logistic regression analyses were used to measure the relationship between ferritin and restrictive and obstructive lung disease. Results: In pre-menopausal women, FEV 1 %/FVC was weakly but positively associated with serum ferritin, and after adjusting for covariates, the association was without statistical significance. No significant association between ferritin and obstructive lung disease was observed. In post-menopausal women, predicted FVC% was negatively associated with serum ferritin, and ferritin was dose-dependently related with risk for restrictive lung disease. The odds ratio for restrictive lung disease in post-menopausal women was 2.285 at Q3 and 1.560 at Q2 relative to that at Q1. Conclusions: High serum ferritin level was significantly associated with lower FVC% and increased risk of restrictive lung disease in tobacco-naïve post-menopausal women. Further study is needed to determine the mechanism underlying the current findings.

Comparison of Laboratory Test Results for Assessing Thyroid Function in Normal Subjects and Treated and Untreated Hyper- and Hypothyroid Patients

1971 ◽  
Vol 17 (3) ◽  
pp. 174-182 ◽  
Author(s):  
Norman D Lee ◽  
Boris Catz ◽  
M S Margolese ◽  
Vincent J Pileggi
Keyword(s):  
Binding Capacity ◽  
Normal Subjects ◽  
Free Thyroxine ◽  
Significant Finding ◽  
Normal Limits ◽  
Laboratory Test Results ◽  
Free Thyroxine Index ◽  
Normal Women ◽  
Normal Men ◽  
Hypothyroid Patients

Abstract Various indexes of thyroid status were measured in sera from normal men and women, normal women who were using oral contraceptives, hyper- and hypothyroid patients, and hypothyroid patients being successfully managed with various forms of replacement therapy. Total circulating thyroxine concentrations were measured by three methods as well as the thyroxine-binding capacity of the serum inter-alpha globulin, "free" thyroxine, and "free" thyroxine index. Our purpose was to compare the various measurements, and to assess their diagnostic usefulness. The most significant finding was that, of 197 hypothyroid patients, all of whom possessed total circulating thyroxine concentrations within normal limits, 28% showed subnormal "free" thyroxine concentrations.

Assessment of rebreathing O2 consumption in humans with normal and diseased lungs

1990 ◽  
Vol 68 (4) ◽  
pp. 1443-1452 ◽  
Author(s):  
M. C. Kallay ◽  
R. W. Hyde ◽  
R. J. Smith
Keyword(s):  
Steady State ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Pulse Rate ◽  
Obstructive Lung Disease ◽  
Pulmonary Function Tests ◽  
Normal Subjects ◽  
O2 Consumption ◽  
O2 Uptake ◽  
End Tidal

We investigated sources of error in estimating steady-state O2 consumption (VO2ss) by calculating O2 uptake from an anesthesia bag containing O2, He, and N2 during 10-20 s of rebreathing (VO2rb). In 11 normal resting subjects, VO2rb calculated with end-tidal sampling overestimated VO2ss by 16 +/- 15% (SD) (P less than 0.003). This error was proportional to the increase in pulse rate during rebreathing, so that pulse-corrected VO2rb slightly underestimated VO2ss by 2.1 +/- 12.2% (P = 0.66) in the six subjects who rebreathed 28% O2 in the rebreathing bag but significantly underestimated VO2ss by 7.5 +/- 6.7% (P less than 0.04) in the six subjects who rebreathed 21% O2 in the rebreathing bag. During exercise, VO2rb underestimated VO2ss by 4 +/- 12% (P less than 0.001) and by 7 +/- 6% at O2 consumptions greater than 2,000 ml/min if O2 in the rebreathing bag was kept above 20% throughout rebreathing. We found that VO2rb calculated with end-tidal gas concentrations underestimated VO2ss by 1-43% in patients with moderate-to-severe obstructive lung disease, with even greater errors when mixed expired samples were used. The magnitude of the discrepancy correlated poorly with abnormalities in standard pulmonary function tests. Based on these data, VO2rb closely approximates VO2ss in normal subjects, provided hypoxia during rebreathing is avoided and cardiac acceleration from rebreathing is taken into account during resting measurement.

RADIOIMMUNOASSAY OF FOLLICLE-STIMULATING (FSH) AND LUTEINIZING (LH) HORMONES BY CHROMATOELECTROPHORESIS

1969 ◽  
Vol 62 (1_Suppl) ◽  
pp. S185-S206 ◽  
Author(s):  
Brij B. Saxena ◽  
Gerhard Leyendecker ◽  
Weiyu Chen ◽  
Hortense M. Gandy ◽  
Ralph E. Peterson
Keyword(s):  
Diurnal Variation ◽  
Plasma Levels ◽  
Normal Subjects ◽  
Regulatory Effect ◽  
Men And Women ◽  
Menstrual Cycles ◽  
Normal Men

ABSTRACT Procedure for the radioimmunoassay of FSH and LH using chromatoelectrophoresis for the separation of antibody-bound and free labeled hormone is described. Diurnal variation in FSH and LH levels of normal men and women in follicular and luteal phases of the cycle is reported. The diurnal variation was not abolished in three women taking contraceptive medication and in two women in postmenopause. The diurnal variation of FSH and LH in plasma is compared with that of cortisol, dehydroepiandrosterone and testosterone. It is suggested that diurnal variation of FSH and LH may be independent of a normally functioning pituitary-gonadal axis; however, steroidal feed-back may have a regulatory effect on the magnitude of the diurnal variation. The plasma levels of FSH and LH in normal subjects during normal menstrual cycles as well as in patients with endocrinopathies obtained in our laboratory by radioimmunoassay are compared with those obtained by both radioimmunoassay and bioassay by other investigators.

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