scholarly journals Radiomics, deep learning and early diagnosis in oncology

2021 ◽  
Author(s):  
Peng Wei
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Medical Imaging ◽  
Early Detection ◽  
Treatment Response ◽  
Critical Role ◽  
Response Prediction ◽  
Computational Implementation ◽  
Magnetic Resonance Imaging Mri ◽  
Treatment Response Prediction

Medical imaging, including X-ray, computed tomography (CT), and magnetic resonance imaging (MRI), plays a critical role in early detection, diagnosis, and treatment response prediction of cancer. To ease radiologists’ task and help with challenging cases, computer-aided diagnosis has been developing rapidly in the past decade, pioneered by radiomics early on, and more recently, driven by deep learning. In this mini-review, I use breast cancer as an example and review how medical imaging and its quantitative modeling, including radiomics and deep learning, have improved the early detection and treatment response prediction of breast cancer. I also outline what radiomics and deep learning share in common and how they differ in terms of modeling procedure, sample size requirement, and computational implementation. Finally, I discuss the challenges and efforts entailed to integrate deep learning models and software in clinical practice.

scholarly journals Deep Learning for Human Disease Detection, Subtype Classification, and Treatment Response Prediction Using Epigenomic Data

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1733
Author(s):  
Thi Mai Nguyen ◽  
Nackhyoung Kim ◽  
Da Hae Kim ◽  
Hoang Long Le ◽  
Md Jalil Piran ◽  
...  
Keyword(s):  
Deep Learning ◽  
Treatment Response ◽  
Human Disease ◽  
Model Performance ◽  
Response Prediction ◽  
Disease Detection ◽  
Sequencing Data ◽  
Subtype Classification ◽  
Treatment Response Prediction ◽  
Classification And Treatment

Deep learning (DL) is a distinct class of machine learning that has achieved first-class performance in many fields of study. For epigenomics, the application of DL to assist physicians and scientists in human disease-relevant prediction tasks has been relatively unexplored until very recently. In this article, we critically review published studies that employed DL models to predict disease detection, subtype classification, and treatment responses, using epigenomic data. A comprehensive search on PubMed, Scopus, Web of Science, Google Scholar, and arXiv.org was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Among 1140 initially identified publications, we included 22 articles in our review. DNA methylation and RNA-sequencing data are most frequently used to train the predictive models. The reviewed models achieved a high accuracy ranged from 88.3% to 100.0% for disease detection tasks, from 69.5% to 97.8% for subtype classification tasks, and from 80.0% to 93.0% for treatment response prediction tasks. We generated a workflow to develop a predictive model that encompasses all steps from first defining human disease-related tasks to finally evaluating model performance. DL holds promise for transforming epigenomic big data into valuable knowledge that will enhance the development of translational epigenomics.

Liquid Biopsies in the Management of Bladder Cancer: Next-Generation Biomarkers for Diagnosis, Surveillance, and Treatment-Response Prediction

2017 ◽  
Vol 22 (5-6) ◽  
pp. 389-401 ◽  
Author(s):  
Yu Yang ◽  
Catherine R. Miller ◽  
Antonio Lopez-Beltran ◽  
Rodolfo Montironi ◽  
Monica Cheng ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Treatment Response ◽  
Response Prediction ◽  
Next Generation ◽  
Liquid Biopsies ◽  
Treatment Response Prediction

Breast Cancer Image Classification: A Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Pooja Pathak ◽  
Anand Singh Jalal ◽  
Ritu Rai
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Treatment Options ◽  
Breast Cancer Diagnosis ◽  
Conventional Approach ◽  
Learning Networks ◽  
Cad System ◽  
Ultrasound Computed Tomography ◽  
Core Concepts ◽  
Magnetic Resonance Imaging Mri

Background: Breast cancer represents uncontrolled breast cell growth. Breast cancer is the most diagnosed cancer in women worldwide. Early detection of breast cancer improves the chances of survival and increases treatment options. There are various methods for screening breast cancer such as mammogram, ultrasound, computed tomography, Magnetic Resonance Imaging (MRI). MRI is gaining prominence as an alternative screening tool for early detection and breast cancer diagnosis. Nevertheless, MRI can hardly be examined without the use of a Computer-Aided Diagnosis (CAD) framework, due to the vast amount of data. Objective: This paper aims to cover the approaches used in CAD system for the detection of breast cancer. Method: In this paper, the methods used in CAD systems are categories in two classes: the conventional approach and artificial intelligence (AI) approach. The conventional approach covers the basic steps of image processing such as preprocessing, segmentation, feature extraction and classification. The AI approach covers the various convolutional and deep learning networks used for diagnosis. Conclusion: This review discusses some of the core concepts used in breast cancer and presents a comprehensive review of efforts in the past to address this problem.

Diagnosing breast cancer tumors using stacked ensemble model

2021 ◽  
pp. 1-9
Author(s):  
Ahmet Haşim Yurttakal ◽  
Hasan Erbay ◽  
Türkan İkizceli ◽  
Seyhan Karaçavuş ◽  
Cenker Biçer
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Medical Imaging ◽  
Early Stage ◽  
False Negative ◽  
Gradient Boosting ◽  
Physical Sign ◽  
Ensemble Model ◽  
Learning Methods ◽  
Dce Mri

Breast cancer is the most common cancer that progresses from cells in the breast tissue among women. Early-stage detection could reduce death rates significantly, and the detection-stage determines the treatment process. Mammography is utilized to discover breast cancer at an early stage prior to any physical sign. However, mammography might return false-negative, in which case, if it is suspected that lesions might have cancer of chance greater than two percent, a biopsy is recommended. About 30 percent of biopsies result in malignancy that means the rate of unnecessary biopsies is high. So to reduce unnecessary biopsies, recently, due to its excellent capability in soft tissue imaging, Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) has been utilized to detect breast cancer. Nowadays, DCE-MRI is a highly recommended method not only to identify breast cancer but also to monitor its development, and to interpret tumorous regions. However, in addition to being a time-consuming process, the accuracy depends on radiologists’ experience. Radiomic data, on the other hand, are used in medical imaging and have the potential to extract disease characteristics that can not be seen by the naked eye. Radiomics are hard-coded features and provide crucial information about the disease where it is imaged. Conversely, deep learning methods like convolutional neural networks(CNNs) learn features automatically from the dataset. Especially in medical imaging, CNNs’ performance is better than compared to hard-coded features-based methods. However, combining the power of these two types of features increases accuracy significantly, which is especially critical in medicine. Herein, a stacked ensemble of gradient boosting and deep learning models were developed to classify breast tumors using DCE-MRI images. The model makes use of radiomics acquired from pixel information in breast DCE-MRI images. Prior to train the model, radiomics had been applied to the factor analysis to refine the feature set and eliminate unuseful features. The performance metrics, as well as the comparisons to some well-known machine learning methods, state the ensemble model outperforms its counterparts. The ensembled model’s accuracy is 94.87% and its AUC value is 0.9728. The recall and precision are 1.0 and 0.9130, respectively, whereas F1-score is 0.9545.

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