The Effect of Parkinson's Disease on Otoacoustic Emissions and Efferent Suppression of Transient Evoked Otoacoustic Emissions

2021 ◽  
Vol 64 (4) ◽  
pp. 1354-1368
Author(s):  
Evelien De Groote ◽  
Annelies Bockstael ◽  
Dick Botteldooren ◽  
Patrick Santens ◽  
Miet De Letter
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Otoacoustic Emissions ◽  
Auditory Function ◽  
Significant Interaction Effect ◽  
Low Frequencies ◽  
Auditory Thresholds ◽  
Distortion Product ◽  
Olivocochlear System ◽  
Efferent Suppression

Purpose Several studies have demonstrated increased auditory thresholds in patients with Parkinson's disease (PD) based on subjective tonal audiometry. However, the pathophysiological mechanisms underlying auditory dysfunction in PD remain elusive. The primary aim of this study was to investigate cochlear and olivocochlear function in PD using objective measurements and to assess the effect of dopaminergic medication on auditory function. Method Eighteen patients with PD and 18 gender- and age-matched healthy controls (HCs) were included. Patients with PD participated in medication on and off conditions. Linear mixed models were used to determine the effect of PD on tonal audiometry, transient evoked and distortion product otoacoustic emissions (OAEs), and efferent suppression (ES). Results Tonal audiometry revealed normal auditory thresholds in patients with PD for their age across all frequencies. OAE signal amplitudes demonstrated a significant interaction effect between group (PD vs. HC) and frequency, indicating decreased OAEs at low frequencies and increased OAEs at high frequencies in patients with PD. No significant differences were found between patients with PD and HCs regarding ES. In addition, no significant effect of medication status was found on auditory measurements in patients with PD. Conclusions Altered OAEs support the hypothesis of cochlear alterations in PD. No evidence was found for the involvement of the medial olivocochlear system. Altogether, OAEs may provide an objective early indicator of auditory alterations in PD and should complement subjective tonal audiometry when assessing and monitoring auditory function in PD.

Evaluation of Efferent Auditory System and Hearing Quality in Parkinson's Disease: Is the Difficulty in Speech Understanding in Complex Listening Conditions Related to Neural Degeneration or Aging?

2020 ◽  
pp. 1-9
Author(s):  
Nuriye Yıldırım Gökay ◽  
Bülent Gündüz ◽  
Fatih Söke ◽  
Recep Karamert
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Auditory System ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Auditory Pathway ◽  
Normal Hearing ◽  
System Function ◽  
Distortion Product

Purpose The effects of neurological diseases on the auditory system have been a notable issue for investigators because the auditory pathway is closely associated with neural systems. The purposes of this study are to evaluate the efferent auditory system function and hearing quality in Parkinson's disease (PD) and to compare the findings with age-matched individuals without PD to present a perspective on aging. Method The study included 35 individuals with PD (mean age of 48.50 ± 8.00 years) and 35 normal-hearing peers (mean age of 49 ± 10 years). The following tests were administered for all participants: the first section of the Speech, Spatial and Qualities of Hearing Scale; pure-tone audiometry, speech audiometry, tympanometry, and acoustic reflexes; and distortion product otoacoustic emissions (DPOAEs) and contralateral suppression of DPOAEs. SPSS Version 25 was used for statistical analyses, and values of p < .05 were considered statistically significant. Results There were no statistically significant differences in the pure-tone audiometry thresholds and DPOAE responses between the individuals with PD and their normal-hearing peers ( p = .732). However, statistically significant differences were found between the groups in suppression levels of DPOAEs and hearing quality ( p < .05). In addition, a statistically significant and positive correlation was found between the amount of suppression at some frequencies and the Speech, Spatial and Qualities of Hearing Scale scores. Conclusions This study indicates that medial olivocochlear efferent system function and the hearing quality of individuals with PD were affected adversely due to the results of PD pathophysiology on the hearing system. For optimal intervention and follow-up, tasks related to hearing quality in daily life can also be added to therapies for PD.

scholarly journals Is there auditory impairment in Parkinson's disease?

Revista CEFAC ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. 573-582 ◽  
Author(s):  
Marcia da Silva Lopes ◽  
Ailton de Souza Melo ◽  
Ana Paula Corona ◽  
Ana Caline Nóbrega
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Hearing Loss ◽  
Auditory Processing ◽  
Otoacoustic Emissions ◽  
Pure Tone Audiometry ◽  
Distortion Product ◽  
Biological Variables ◽  
Initial Stage ◽  
Auditory Impairment

ABSTRACT Objective: to describe the audiological profile of a group of patients with Parkinson's disease and to investigate the association between hearing loss and the disease. Methods: 50 individuals with and 46 without Parkinson's disease underwent Pure Tone Audiometry, Otoacoustic Emissions by Distortion Product, and auditory processing tests. The results of the patients were compared to those obtained in individuals without the disease, according to clinical and biological variables. Results: in individuals with Parkinson's disease, 82% presented hearing loss, 53.5% alterations in Otoacoustic Emissions by Distortion Product, 78%, alterations in temporal processing, and 12%, changes in binaural integration. Individuals with the disease had a greater impairment in the recognition of duration patterns when compared to those without the disease, with a worse performance in men and in individuals aged between 42 and 65 years old and Hoehn and Yahr I and II stages. Conclusions: the profile found corresponds to descending sensorineural hearing loss and alteration in otoacoustic emissions, temporal ordering and noise gaps detection.Only losses in temporal order are associated with the disease, especially in men, individuals under the age of 65 and in the initial stage.

Early Changes in Auditory Function As a Result of Platinum Chemotherapy: Use of Extended High-Frequency Audiometry and Evoked Distortion Product Otoacoustic Emissions

2007 ◽  
Vol 25 (10) ◽  
pp. 1190-1195 ◽  
Author(s):  
Kristin R. Knight ◽  
Dale F. Kraemer ◽  
Christiane Winter ◽  
Edward A. Neuwelt
Keyword(s):  
High Frequency ◽  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Auditory Function ◽  
Cochlear Function ◽  
Serial Measurement ◽  
Distortion Product ◽  
High Frequency Audiometry ◽  
Platinum Based Chemotherapy ◽  
Platinum Chemotherapy

Purpose The objective is to describe progressive changes in hearing and cochlear function in children and adolescents treated with platinum-based chemotherapy and to begin preliminary evaluation of the feasibility of extended high-frequency audiometry and distortion product otoacoustic emissions for ototoxicity monitoring in children. Patients and Methods Baseline and serial measurement of conventional pure-tone audiometry (0.5 to 8 kHz) and evoked distortion product otoacoustic emissions (DPOAEs) were conducted for 32 patients age 8 months to 20 years who were treated with cisplatin and/or carboplatin chemotherapy. Seventeen children also had baseline and serial measurement of extended high-frequency (EHF) audiometry (9 to 16 kHz). Audiologic data were analyzed to determine the incidence of ototoxicity using the American Speech-Language-Hearing Association criteria, and the relationships between the different measures of ototoxicity. Results Of the 32 children, 20 (62.5%) acquired bilateral ototoxicity in the conventional frequency range during chemotherapy treatment, and 26 (81.3%) had bilateral decreases in DPOAE amplitudes and dynamic range. Of the 17 children with EHF audiometry results, 16 (94.1%) had bilateral ototoxicity in the EHF range. Pilot data suggest that EHF thresholds and DPOAEs show ototoxic changes before hearing loss is detected by conventional audiometry. Conclusion EHF audiometry and DPOAEs have the potential to reveal earlier changes in auditory function than conventional frequency audiometry during platinum chemotherapy in children.

scholarly journals Lateralization of cochlear dysfunction as a specific biomarker of Parkinson’s disease

2020 ◽  
Author(s):  
Renata Sisto ◽  
Andrea Viziano ◽  
Alessandro Stefani ◽  
Arturo Moleti ◽  
Rocco Cerroni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Outcome Variable ◽  
Elderly Subjects ◽  
Motor Symptoms ◽  
Hearing Function ◽  
Cochlear Damage ◽  
Cochlear Dysfunction

Abstract In the last decade, animal studies highlighted the sensitivity of hearing function to lack of specific cochlear dopamine receptors, while several studies on humans reported association between hearing loss and Parkinson’s disease, partially recovered after levodopa administration in de novo patients. Taken together, these observations suggest investigating the possible use of cochlear function outcome variables, particularly, otoacoustic emissions, as sensitive biomarkers of Parkinson’s disease. Any lateralization of hearing dysfunction correlated with Parkinson’s disease lateralization would 1) further confirm their association, and 2) provide a disease-specific differential outcome variable. Differential indicators are particularly useful for diagnostic purposes, because their effectiveness is not limited by physiological inter-subject fluctuations of the outcome variable. Recent advances in the acquisition and analysis techniques of otoacoustic emissions suggest using them for evaluating differential cochlear damage in the two ears. In this study, we quantitatively evaluated hearing function in a population of subjects with Parkinson’s disease, to investigate the occurrence of hearing loss, and, particularly, whether hearing dysfunction shows lateralization correlated to motor symptoms. Pure tone audiometry and distortion product otoacoustic emissions were used as outcome variables in eighty patients (mean age 65 ± 9 years) and forty-one controls (mean age 64 ± 10 years). An advanced customized acquisition and analysis system was developed and used for otoacoustic testing, which guarantees response stability independent of probe insertion depth, and has the sensitivity necessary to accurately assess the low levels of otoacoustic response typical of elderly subjects. To our knowledge, this is the first study introducing the distinction between ipsilateral and contralateral ear, with respect to the body side more affected by Parkinson’s disease motor symptoms. Significant asymmetry was found in the auditory function, as both otoacoustic responses and audiometric hearing levels were worse in the ipsilateral ear. Significantly worse hearing function was also observed in patients with Parkinson’s disease compared to controls, confirming previous studies. Several pathophysiological mechanisms may be hypothesized to explain asymmetric cochlear damage in Parkinson's disease, including the impairment of dopamine release and the involvement of extra-dopaminergic circuits, with the cholinergic pathway as a likely candidate. The observed asymmetry in the audiological response of patients with Parkinson’s disease suggests that lateralization of hearing dysfunction could represent a specific non-motor signature of the disease. The possible diagnostic use of cochlear dysfunction asymmetry as a specific biomarker of Parkinson’s disease deserves further investigation, needing a more precise quantitative assessment, which would require a larger sample size.

scholarly journals Hearing Performance in the Follicular-Luteal Phase of the Menstrual Cycle

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Seyede Faranak Emami ◽  
Nasrin Gohari ◽  
Hossein Ramezani ◽  
Mariam Borzouei
Keyword(s):  
Menstrual Cycle ◽  
Otoacoustic Emissions ◽  
Luteal Phase ◽  
Pure Tone Audiometry ◽  
Nerve Fibers ◽  
Follicular Phase ◽  
Auditory Brainstem Responses ◽  
Auditory Function ◽  
Distortion Product ◽  
Excitatory Action

Introduction. Estrogen has a protective role on auditory function. It may have an excitatory action on auditory nerve fibers and can have a neuroprotective effect. Progesterone has a mainly inhibitory action on the central nervous system, which may balance the mainly excitatory action of estrogen. Objective. To determine changes in hearing performance with pure tone audiometry (PTA), tympanometry, distortion product otoacoustic emissions (DPOAEs), and auditory brainstem responses (ABR) as hormonal changes occur from follicular to luteal phase. Materials and Methods. Twenty healthy female volunteers (age 19 ± 30 years) with normal menstrual cycle and without any hearing problems are included in this case-control study. Hearing evaluation was performed on the 13th day of the menstrual cycle (follicular phase) and then on the 22nd day (luteal phase). Results. All of the participants had normal results in follicular phase. In luteal phase, four cases showed abnormalities as follows: reduced hearing thresholds 250 Hz (mean= 15 dBHL), increased amplitudes of DPOAE (mean= 3 dBspl), decreased middle ear pressure (mean= -110 dapa), and delayed ABR interpeak latencies (mean of IPLs I-III= 0.4 and mean of IPLs III-V= 0.6 ms). Conclusions. In some women, changing of ovarian hormones may induce fluctuating hearing and increased progesterone in luteal phase can lead to abnormal outcomes in auditory function. However, elevated estrogen modifies its consequences in follicular phase.

Effect of contralateral pure tone stimulation on distortion emissions suggests a frequency-specific functioning of the efferent cochlear control

2012 ◽  
Vol 107 (7) ◽  
pp. 1962-1969 ◽  
Author(s):  
H. Althen ◽  
A. Wittekindt ◽  
B. Gaese ◽  
M. Kössl ◽  
C. Abel
Keyword(s):  
White Noise ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Specific Effect ◽  
Outer Hair Cells ◽  
Efferent Activity ◽  
Distortion Product ◽  
Frequency Specificity ◽  
Olivocochlear System ◽  
Pure Tones

Contralateral acoustic stimulation (CAS) with white noise and pure tone stimuli was used to assess frequency specificity of efferent olivocochlear control of cochlear mechanics in the gerbil. Changes of the cochlear amplifier can be monitored by distortion product otoacoustic emissions (DPOAEs), which are a byproduct of the nonlinear amplification by the outer hair cells. We used the quadratic DPOAE f2-f1 as ipsilateral probe, as it is known to be sensitive to efferent olivocochlear activity. White noise CAS, used to evoke efferent activity, had maximal effects on the DPOAE level for f2-stimulus frequencies of 5–7 kHz. The dominant effect during CAS was a DPOAE level increase of up to 13.5 dB. The frequency specificity of the olivocochlear system was evaluated by presenting pure tones (0.5–38 kHz) as contralateral stimuli to evoke efferent activity. Maximal DPOAE level changes were triggered by CAS frequencies close to the frequency of the DPOAE elicitor tones (tested f2 range: 2.5–15 kHz). The effective CAS frequency range covered 1.4–2.4 octaves and was centered 0.42 octaves below the DPOAE elicitor tone f2. The frequency-specific effect of CAS with pure tones suggests a dedicated central control of mechanical adjustments for peripheral frequency processing.

scholarly journals Hearing function in twins from spontaneous and induced pregnancy

2019 ◽  
Vol 64 (5) ◽  
pp. 49-54
Author(s):  
I. V. Rakhmanova ◽  
L. G. Sichinava ◽  
S. Yu. Lebedeva
Keyword(s):  
Otoacoustic Emissions ◽  
Assisted Reproductive Technologies ◽  
Multiple Pregnancy ◽  
Reproductive Technologies ◽  
High Risk Group ◽  
Multiple Pregnancies ◽  
Auditory Function ◽  
Vitro Fertilization ◽  
Distortion Product

In recent years, an increase in the frequency of multiple pregnancies has been observed worldwide, which is primarily associated with the widespread use of assisted reproductive technology for the treatment of infertility. Pregnancy resulting from in vitro fertilization is a high-risk group. In the world scientific literature there are practically no works on the study of auditory function in children from multiple pregnancy. As for the studies of the auditory function of children from multiple pregnancies, such works are practically absent in the literature. The article presents the results of an audiological examination of 204 children from twins, 94 of which were born as a result of using assisted reproductive technologies, and 110 from a spontaneous multiple pregnancy. According to an audiological survey using the method of otoacoustic emission at the frequency of product distortion in the expected period of labor, we have proven that the conception method (spontaneous or induced) does not affect the maturation of the auditory function in children from twins: registration of the distortion product otoacoustic emissions (DPOAE) test is 56,1 and 54,4% of cases, respectively. The auditory function of each child from one twin must be considered individually.

scholarly journals Neural Substrates for the Association Between Cigarette Smoking and Parkinson's Disease

2021 ◽  
Author(s):  
Chao Wang ◽  
Cheng Zhou ◽  
Tao Guo ◽  
Peiyu Huang ◽  
Xiaojun Xu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cigarette Smoking ◽  
Protective Effect ◽  
Substantial Reduction ◽  
Neural Substrates ◽  
Smoking History ◽  
Healthy Controls ◽  
Significant Interaction Effect ◽  
Harmful Effects

Abstract Background: Mounting evidence revealed a causally protective effect of cigarette smoking on the risk of Parkinson’s disease (PD). Meanwhile, cigarette smoking also was found to be associated with cognitive impairment in PD patients. However, the neural substrates of the protective and harmful effects of cigarette smoking on PD are not fully illustrated. Therefore, in this study, we explored the neural substrates for the protective and harmful effects of cigarette smoking on PD.Methods: A total of 129 PD patients and 69 controls were recruited from the Parkinson’s Progression Markers Initiative (PPMI) cohort, including 39 PD patients with regular smoking history (PD-S), 90 PD patients without regular smoking history (PD-NS), 26 healthy controls with regular smoking history (HC-S) and 43 healthy controls without regular smoking history (HC-NS). Striatal dopamine transporter (DAT) binding and gray matter (GM) volume of the whole brain were compared among the four groups.Results: PD patients showed significantly reduced striatal DAT binding compared with healthy controls, and HC-S showed significantly reduced striatal DAT binding compared with HC-NS. Moreover, smoking and PD showed a significant interaction effect in the left medial prefrontal cortex (mPFC). PD-S showed reduced GM volume in the left mPFC compared with PD-NS.Conclusions: This study is the first to reveal the neural substrates for both the protective and harmful effects of smoking on PD. The degeneration of dopaminergic neurons in PD results in a substantial reduction of the DAT and dopamine levels. Nicotine may act as a stimulant to inhibit the action of striatal DAT, increasing dopamine levels in the synaptic gap. The inverse alterations of dopamine levels between PD and nicotine addiction may be the neural substrates for the protective effect of smoking on the risk of PD. In addition, the mPFC atrophy in PD-S may be the neural substrates for the harmful impact of smoking on PD.

Systematic Audiological Assessment of Auditory Functioning in Patients With Parkinson's Disease

2019 ◽  
Vol 62 (12) ◽  
pp. 4564-4577 ◽  
Author(s):  
Kim De Keyser ◽  
Miet De Letter ◽  
Evelien De Groote ◽  
Patrick Santens ◽  
Durk Talsma ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Auditory Processing ◽  
Otoacoustic Emissions ◽  
Outer Hair Cell ◽  
Speech Audiometry ◽  
Disease Stage ◽  
Sensitivity Index ◽  
Healthy Controls ◽  
Dopaminergic Medication

Purpose Alterations in primary auditory functioning have been reported in patients with Parkinson's disease (PD). Despite the current findings, the pathophysiological mechanisms underlying these alterations remain unclear, and the effect of dopaminergic medication on auditory functioning in PD has been explored insufficiently. Therefore, this study aimed to systematically investigate primary auditory functioning in patients with PD by using both subjective and objective audiological measurements. Method In this case–control study, 25 patients with PD and 25 age-, gender-, and education-matched healthy controls underwent an audiological test battery consisting of tonal audiometry, short increment sensitivity index, otoacoustic emissions (OAEs), and speech audiometry. Patients with PD were tested in the on- and off-medication states. Results Increased OAE amplitudes were found when patients with PD were tested without dopaminergic medication. In addition, speech audiometry in silence and multitalker babble noise demonstrated higher phoneme scores for patients with PD in the off-medication condition. The results showed no differences in auditory functioning between patients with PD in the on-medication condition and healthy controls. No effect of disease stage or motor score was evident. Conclusions This study provides evidence for a top-down involvement in auditory processing in PD at both central and peripheral levels. Most important, the increase in OAE amplitude in the off-medication condition in PD is hypothesized to be linked to a dysfunction of the olivocochlear efferent system, which is known to have an inhibitory effect on outer hair cell functioning. Future studies may clarify whether OAEs may facilitate an early diagnosis of PD.

Sign in / Sign up

Export Citation Format

Share Document