Maturation of Peripheral and Brainstem Auditory Function in the First Year Following Perinatal Asphyxia

Maturation of peripheral hearing and auditory brainstem following perinatal asphyxia was investigated by longitudinal recording of brainstem auditory evoked potentials (BAEP) during the first year of life in affected infants. The general maturational course of the BAEP following asphyxia was similar to that in a control group of infants with normal births, although there were some abnormalities in the BAEP. Response threshold elevation seen in a few asphyxiated infants improved significantly during the first 3 months. The interpeak intervals in the asphyxiated infants did not differ significantly from that of the control-group infants except in the first month, when the I–V and III–V intervals were significantly prolonged in the severe asphyxia group. In contrast, wave V amplitude and V/I ratio were always smaller when compared to that of the control-group infants. Amplitude reduction of wave V was more sustained than the prolonged I–V interval. Persistent hearing loss and brainstem auditory impairment were seen in 6.8% and 14.6% of the asphyxiated infants, respectively. These findings suggest that asphyxia does not interfere significantly with the maturation of the auditory system in most asphyxiated infants and that sustained peripheral hearing loss and brainstem impairment occur only in a small proportion of affected infants.

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Mitochondria-Targeted Antioxidant Mitoquinone Reduces Cisplatin-Induced Ototoxicity in Guinea Pigs

Otolaryngology ◽

10.1177/0194599816678381 ◽

2016 ◽

Vol 156 (3) ◽

pp. 543-548 ◽

Cited By ~ 13

Author(s):

Alan D. Tate ◽

Patrick J. Antonelli ◽

Kyle R. Hannabass ◽

Carolyn O. Dirain

Keyword(s):

Hearing Loss ◽

Auditory Brainstem Response ◽

Guinea Pigs ◽

Outer Hair Cell ◽

Auditory Brainstem ◽

Response Threshold ◽

Saline Control ◽

Control Group ◽

Cochlear Hair Cells ◽

Brainstem Response

Objective To determine if mitoquinone (MitoQ) attenuates cisplatin-induced hearing loss in guinea pigs. Study Design Prospective and controlled animal study. Setting Academic, tertiary medical center. Subjects and Methods Guinea pigs were injected subcutaneously with either 5 mg/kg MitoQ (n = 9) or normal saline (control, n = 9) for 7 days and 1 hour before receiving a single dose of 10 mg/kg cisplatin. Auditory brainstem response thresholds were measured before MitoQ or saline administration and 3 to 4 days after cisplatin administration. Results Auditory brainstem response threshold shifts after cisplatin treatment were smaller by 28 to 47 dB in guinea pigs injected with MitoQ compared with those in the control group at all tested frequencies (4, 8, 16, and 24 kHz, P = .0002 to .04). Scanning electron microscopy of cochlear hair cells showed less outer hair cell loss and damage in the MitoQ group. Conclusion MitoQ reduced cisplatin-induced hearing loss in guinea pigs. MitoQ appears worthy of further investigation as a means of preventing cisplatin ototoxicity in humans.

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Antioxidant Enzyme Levels Inversely Covary with Hearing Loss After Amikacin Treatment

Journal of the American Academy of Audiology ◽

10.1055/s-0040-1715718 ◽

2003 ◽

Vol 14 (03) ◽

pp. 134-143 ◽

Cited By ~ 6

Author(s):

James J. Klemens ◽

Robert P. Meech ◽

Larry F. Hughes ◽

Satu Somani ◽

Kathleen C.M. Campbell

Keyword(s):

Hearing Loss ◽

Enzyme Activity ◽

Antioxidant Enzyme ◽

Guinea Pigs ◽

Auditory Brainstem ◽

Antioxidant Enzyme Activity ◽

Control Group ◽

Glutathione S Transferase ◽

Brainstem Response ◽

The Difference

This study's purpose was to determine if a correlation exists between cochlear antioxidant activity changes and auditory function after induction of aminoglycoside (AG) ototoxicity. Two groups of five 250-350 g albino guinea pigs served as subjects. For 28 days, albino guinea pigs were administered either 200 mg/kg/day amikacin, or saline subcutaneously. Auditory brainstem response testing was performed prior to the first injection and again before sacrifice, 28 days later. Cochleae were harvested and superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase activities and malondialdehyde levels were measured. All antioxidant enzymes had significantly lower activity in the amikacin group (p ≤ 0.05) than in the control group. The difference in cochlear antioxidant enzyme activity between groups inversely correlated significantly with the change in ABR thresholds. The greatest correlation was for the high frequencies, which are most affected by aminoglycosides. This study demonstrates that antioxidant enzyme activity and amikacin-induced hearing loss significantly covary.

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Monitoring of the auditory pathway maturation after early intervention during the first year of life in infants with sensorineural hearing loss

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-020-06498-3 ◽

2020 ◽

Author(s):

F. Matin ◽

S. Haumann ◽

W. Roßberg ◽

D. Mitovska ◽

T. Lenarz ◽

...

Keyword(s):

Hearing Loss ◽

Early Intervention ◽

Hearing Aids ◽

Hearing Threshold ◽

Auditory Pathway ◽

Auditory Brainstem Responses ◽

First Year ◽

Early Therapy ◽

Hearing Thresholds ◽

First Year Of Life

Abstract Purpose The objective of this study was to investigate the auditory pathway maturation monitored by auditory brainstem responses (ABR) in infants with hearing loss during the first year of life. ABR were used to estimate hearing thresholds and the effect of early intervention strategies using hearing aids (HA). Methods Click-evoked ABRs were measured in 102 infants aged from 0 to 12 months to determine their individual auditory threshold. Early therapy intervention was recommended before 12 months of age and analyzed. To evaluate the effect of hearing amplification on auditory maturation, different subgroups of infants with moderate hearing loss were analyzed and the auditory pathway maturation was determined based on IPL I–V shortening. Results Overall, 110 ears (54.0% of 204 ears) with mild to profound HL showed threshold changes of 10 dB up to 60 dB in the follow-up ABR testing. HA were prescribed at the age of 3.8 ± 3.9 months. Cochlear implantation (CI) was performed in cases of repeated profound HL at the age of 9.9 months ± 4.5 months. A significant shortening of IPL I–V in all subgroups of infants (with and without risk factors) who received HA was shown and assumed auditory pathway maturation. Conclusion An early intervention using optimally fitted HA influenced auditory pathway maturation and may lead to improvements of hearing thresholds during the first year of life in infants. This study underscores the importance of not only providing HAs to infants, but also controlling for hearing threshold changes ensuring that HAs provide the optimal level of intervention or CI is indicated.

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Auditory temporal abilities in children with history of recurrent otitis media in the first years of life and persistent in preschool and school ages

CoDAS ◽

10.1590/2317-1782/20142014008 ◽

2014 ◽

Vol 26 (6) ◽

pp. 494-502 ◽

Cited By ~ 2

Author(s):

Priscila Cruvinel Villa ◽

Sthella Zanchetta

Keyword(s):

Otitis Media ◽

Otitis Media With Effusion ◽

Temporal Frequency ◽

Control Group ◽

First Year ◽

Normal Range ◽

Frequency Pattern ◽

History Of ◽

First Year Of Life ◽

Recurrent Otitis Media

PURPOSE: To study the temporal auditory ordering and resolution abilities in children with and without a history of early OME and ROME, as well as to study the responses according to age. METHODS: A total of 59 children were evaluated, and all of them presented pure tone thresholds within the normal range at the time of the conduction of the hearing tests. The children were divided into two groups according to the occurrence of episodes of recurrent otitis media. Then, each group was divided into two subgroups according to age: 7- and 8-year olds, and 9- and 10-year olds. All children were assessed with standard tests of temporal frequency (ordination) and gaps-in-noise (resolution). RESULTS: For the temporal abilities studied, children with a history of otitis media presented significantly lower results compared to the control group. In the frequency pattern test, the correct answers increased with age in both groups. In the identification of silence intervals, the control group showed no change in threshold regarding to age, but this change was present in the group with a history of otitis media. CONCLUSION: Episodes of otitis media with effusion in the first year of life, recurrent and persistent in preschool and school ages, negatively influence the temporal ordering and resolution abilities.

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BILINGUALISM IN CHILDREN HAVING CONGENITAL BILATERAL PROFOUND SENSORI NEURAL HEARING LOSS – CASE REVIEW

Pakistan Journal of Rehabilitation ◽

10.36283/pjr.zu.1.2/004 ◽

2012 ◽

Vol 1 (2) ◽

pp. 11-16

Author(s):

Amina Asif Siddiqui

Keyword(s):

Hearing Loss ◽

Inclusive Education ◽

First Year ◽

Case Review ◽

The Past ◽

Past Half Century ◽

High Intelligence ◽

Mainstream Society ◽

First Year Of Life ◽

Developed World

The age old understanding that an individual with a hearing loss is incapable of acquiring verbal communication skills was readily accepted in the past, which led to the inadvertent but unfortunate coining of phrases “deaf and dumb” or “deaf and mute, " and the development of non-verbal or manual communication methodolgies of Sign language. Further, this caused the segregation and isolation of otherwise physically and intellectually competent individuals from mainstream society, unjustifiably denying them opportunities of education and vocation. Studies have proved that in the absence of any organic or inorganic complication, a child with a hearing loss may not only score a high Intelligence Quotient but can also acquire more than one language fluently. Early Intervention with appropriate amplification of residual hearing is underscored as the fundamental prerequisite for children with bilateral congenital profound sensorineural hearing loss, for subsequent acquisition of good listening and normal speech-language skills and plausible bilingualism; that further equips them with scholastic achievements comparable to their hearing peers. The past half century has witnessed stupendous technological enhancements in amplification devices manufactured for children having hearing loss, complemented by steady success in fostering their Inclusive Education. This paper highlights the urgent need in Pakistan to address this issue as well as the importance of early detection, diagnosis, and (re)habilitation along with parent training initiated within the first year of life. An otherwise anticipated disabling condition may be overcome completely if neonatal screening, which is not only inexpensive but also easy to perform; is made mandatory at all hospitals and maternity homes, as practiced in the developed world. This shall ease the challenges faced by the families of children having hearing loss; and enable the professionals working with them to successfully alleviate their communicative, social, educational and vocational difficulties, and ensure that they become successfully contributing members of our verbal society.

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Sudden Infant Death Syndrome in a Twin: A Comparison of Sibling Histories

PEDIATRICS ◽

10.1542/peds.78.1.146 ◽

1986 ◽

Vol 78 (1) ◽

pp. 146-150

Author(s):

A. Kahn ◽

D. Blum ◽

M. F. Muller ◽

L. Montauk ◽

A. Bochner ◽

...

Keyword(s):

Sudden Infant Death Syndrome ◽

Infant Death ◽

Sudden Infant Death ◽

Clinical Risk Factor ◽

Control Group ◽

Sudden Infant ◽

First Year ◽

Control Infant ◽

The Mean ◽

First Year Of Life

To determine possible characteristics of infant victims of sudden death, we examined 114 items related to the pre- and postnatal histories of 42 pairs of twins one of whom died of sudden infant death syndrome (SIDS) leaving a surviving sibling. Interviews with the parents were conducted after the occurrence of SIDS, and the data were checked with records held by gynecologists and pediatricians. To evaluate the specificity of any factors, we studied a control group of 42 age- and sex-matched pairs of twins, both of whom survived the first year of life. Only 11 of 114 characteristics were significantly related to SIDS: future victims had a smaller weight and height at birth, stayed longer in the nursery, and followed a moving object with their eyes, had head control, and smiled at a later age than their surviving siblings. They also fatigued more often during feeding (11/42) and had reduced arm and neck tonus (9/42). They were described as longer sleepers than their surviving siblings. During sleep, some SIDS twins, but no surviving twin, were found to be cyanotic at least once or pale (4/42) and were repeatedly covered with abundant sweat (8/42). In the control group of normal twins, the occurrence of most of these characteristics was found with a frequency comparable to that seen in the SIDS infants; the specificity of these characteristics is thus considered doubtful. The mean birth weight and height were significantly greater in the control group, and no control infant had an episode of cyanosis or pallor or repeated episodes of profuse sweating observed during their sleep. It is concluded that, if further research validates the occurrence of night hyperhydrosis in some future SIDS victims, this symptom could be a clinical risk factor.

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Analysis of Click and Swept-Tone Auditory Brainstem Response Results for Moderate and Severe Sensorineural Hearing Loss

Audiology and Neurotology ◽

10.1159/000507691 ◽

2020 ◽

Vol 25 (6) ◽

pp. 336-344

Author(s):

Jingqian Tan ◽

Jia Luo ◽

Xin Wang ◽

Yanbing Jiang ◽

Xiangli Zeng ◽

...

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Auditory Brainstem Response ◽

Basilar Membrane ◽

Auditory Brainstem ◽

Sensorineural Hearing ◽

Control Group ◽

Hearing Sensitivity ◽

Brainstem Response ◽

Frequency Components

Introduction: Auditory brainstem response (ABR) is one of the commonly used methods in clinical settings to evaluate the hearing sensitivity and auditory function. The current ABR measurement usually adopts click sound as the stimuli. However, there may be partial ABR amplitude attenuation due to the delay characteristics of the cochlear traveling wave along the basilar membrane. To solve that problem, a swept-tone method was proposed, in which the show-up time of different frequency components was adjusted to compensate the delay characteristics of the cochlear basilar membrane; therefore, different ABR subcomponents of different frequencies were synchronized. Methods: The normal hearing group, moderate sensorineural hearing loss group, and severe sensorineural hearing loss group underwent click ABR and swept-tone ABR with different stimulus intensities. The latencies and amplitudes of waves I, III, and V in 2 detections were recorded. Results: It was found that the latency of each of the recorded I, III, and V waves detected by swept-tone ABR was shorter than that by click ABR in both the control group and experimental groups. In addition, the amplitude of each of the recorded I, III, and V waves, except V waves under 60 dB nHL in the moderate sensorineural hearing loss group, detected by swept-tone ABR was larger than that by click ABR. The results also showed that the swept-tone ABR could measure the visible V waves at lower stimulus levels in the severe sensorineural hearing loss group. Conclusion: Swept-tone improves the ABR waveforms and helps to obtain more accurate threshold to some extent. Therefore, the proposed swept-tone ABR may provide a new solution for better morphology of ABR waveform, which can help to make more accurate diagnosis about the hearing functionality in the clinic.

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Brainstem auditory evoked potentials in children with microcephaly

Paediatrica Indonesiana ◽

10.14238/pi43.1.2003.28-30 ◽

2016 ◽

Vol 43 (1) ◽

pp. 28

Author(s):

Irawan Mangunatmadja ◽

Dwi Putro Widodo ◽

Hardiono D Pusponegoro

Keyword(s):

Hearing Loss ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Clinical Manifestations ◽

Auditory Brainstem ◽

Brainstem Auditory Evoked Potentials ◽

Perinatal Infection ◽

History Of ◽

Delayed Development

Background Hearing loss (HL) is commonly found in childrenwith microcephaly. The aim of this study was to reveal hearing lossand auditory brainstem pathways disorders in children with micro-cephaly and other handicaps.Methods There were 194 children who were referred for hearingevaluation. Subjects with history of congenital perinatal infection(TORCH) were excluded. Data were collected from the results ofBrainstem Auditory Evoked Potentials (BAEP) recordings, includ-ing sex, age, clinical manifestations, latency and interlatency be-tween waves I, III, V, and the hearing levels of each ear.Results Moderate to profound HL were found in fourteen ears(58%) of patients with microcephaly. Moderate to profound HL (28%)and endocochlear damage (15%) were found in the ears of pa-tients with microcephaly and delayed speech. Moderate to pro-found HL (39%) and endocochlear damage (11%) were detectedin the ears of patients with microcephaly and delayed develop-ment. Moderate to profound HL (21%) and endocochlear damage(16%) were found in the ears of microcephalic patients with bothdelayed speech and delayed development. Moderate to profoundHL (26%) and endocochlear damage (32%) were detected in theears of patients with microcephaly and cerebral palsy.Conclusion This study revealed the importance of early HL de-tection in microcephalic patients especially those with other handi-caps such as delayed speech, delayed development, and cere-bral palsy

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Impact of Unilateral Hearing Loss on Behavioral and Evoked Potential Measures of Auditory Function in Adults

Journal of the American Academy of Audiology ◽

10.3766/jaaa.17096 ◽

2019 ◽

Vol 30 (07) ◽

pp. 564-578

Author(s):

Oscar M. Cañete ◽

Suzanne C. Purdy ◽

Colin R. S. Brown ◽

Michel Neeff ◽

Peter R. Thorne

Keyword(s):

Hearing Loss ◽

Speech Recognition ◽

Sound Localization ◽

Auditory Evoked Potentials ◽

Social Impact ◽

Unilateral Hearing Loss ◽

Control Group ◽

Self Perception ◽

Listening Effort ◽

Speech Detection

AbstractA unilateral hearing loss (UHL) can have a significant functional and social impact on children and adults, affecting their quality of life. In adults, UHL is typically associated with difficulties understanding speech in noise and sound localization, and UHL increases the self-perception of auditory disability for a range of listening situations. Furthermore, despite evidence for the negative effects of reduced unilateral auditory input on the neural encoding of binaural cues, the perceptual consequences of these changes are still not well understood.Determine effects of UHL on auditory abilities and speech-evoked cortical auditory evoked potentials (CAEPs).CAEPs, sound localization, speech perception in noise and self-perception of auditory abilities (speech, spatial, and qualities hearing scale) were assessed.Thirteen adults with UHL with a range of etiologies, duration of hearing loss, and severity and a control group of eleven binaural listeners with normal hearing.Participants with UHL varied greatly in their ability to localize sound and reported speech recognition and listening effort were the greatest problem. There was a greater effect of right ear than left ear hearing loss on N1 amplitude hemispheric asymmetry and N1 latencies evoked by speech syllables in noise. As duration of hearing loss increased, contralateral dominance (N1 amplitude asymmetry) decreased. N1 amplitudes correlated with speech scores, larger N1 amplitudes were associated with better speech recognition in noise scores. N1 latencies are delayed (in the better ear) and amplitude hemisphere asymmetry differed across UHL participants as function of side of deafness, mainly for right-sided deafness.UHL affects a range of auditory abilities, including speech detection in noise, sound localization, and self-perceived hearing disability. CAEPs elicited by speech sounds are sensitive enough to evidence changes within the auditory cortex due to an UHL.

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