Thyroid volume and function after 131 I treatment of diffuse non-toxic goitre

1997 ◽  
Vol 46 (4) ◽  
pp. 493-496 ◽  
Author(s):  
B. Nygaard ◽  
J. Faber ◽  
A. Veje ◽  
J. E. M. Hansen
Keyword(s):  
Thyroid Volume ◽  
And Function

Recombinant human TSH associated with radioiodine does not have further effects on thyroid volume and function after 2 years

2008 ◽  
Vol 69 (2) ◽  
pp. 345-346 ◽  
Author(s):  
G. J. Paz-Filho ◽  
C. O. Mesa ◽  
G. A. Carvalho ◽  
C. A. Goedert ◽  
H. Graf
Keyword(s):  
Thyroid Volume ◽  
Recombinant Human Tsh ◽  
And Function

scholarly journals Thyroid Morphology and Function in Adults with Untreated Isolated Growth Hormone Deficiency

2006 ◽  
Vol 91 (3) ◽  
pp. 860-864 ◽  
Author(s):  
Marta Regina Silva Alcântara ◽  
Roberto Salvatori ◽  
Paula Regina Silva Alcântara ◽  
Luciana Michele A. Nóbrega ◽  
Vera Simone Campos ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Thyroid Volume ◽  
Normal Subjects ◽  
Serum Levels ◽  
Hormone Deficiency ◽  
Homozygous Mutation ◽  
Free T4 ◽  
Thyroid Morphology ◽  
The Difference ◽  
And Function

Abstract Objective: GH influences thyroid function and anatomy. Although goiter is frequent in acromegalic patients, the effects of GH deficiency (GHD) are difficult to assess, because hypopituitaric subjects who lack GH often also have a partial or complete deficit of TSH. Study Design: We studied thyroid morphology and serum levels of thyroid hormones in adult members of a large Brazilian kindred with untreated isolated GHD due to a homozygous mutation in the GHRH receptor gene (GHRHR; nine men and 15 women; GHD group) and compared them to subjects heterozygous for the same mutation (eight men and 10 women; HET group) and subjects homozygous for the wild-type allele [seven men and 11 women; control (CO) group]. Results: GHD subjects had a smaller thyroid volume (TV) than HET and CO. The TV of the HET group was intermediate between those of the GHD and CO groups. When TV was corrected by body surface area, it remained smaller in the GHD and HET groups than in the CO group, but the difference between GHD and HET groups disappeared. The GHD group had lower serum T3 levels than the CO group and higher free T4 levels than HET and CO groups. Conclusions: Individuals with severe untreated GHD due to a homozygous GHRHR mutation and heterozygous carriers of the same mutation have smaller TV than normal subjects, suggesting that GH has a permissive role in the growth of the thyroid gland. In addition, GHD subjects have reduced serum total T3 and increased serum free T4, suggesting a reduction in the function of the deiodinase system.

Thyroid volume and function in patients with acromegaly living in iodine deficient areas

1997 ◽  
Vol 20 (3) ◽  
pp. 134-137 ◽  
Author(s):  
R. Junik ◽  
J. Sawicka ◽  
W. Kozak ◽  
M. Gembicki
Keyword(s):  
Thyroid Volume ◽  
And Function

The effect of body weight and weight loss on thyroid volume and function in obese women

2003 ◽  
Vol 59 (2) ◽  
pp. 258-262 ◽  
Author(s):  
Ramazan Sari ◽  
Mustafa Kemal Balci ◽  
Hasan Altunbas ◽  
Umit Karayalcin
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Thyroid Volume ◽  
Obese Women ◽  
And Function

scholarly journals Thyroid size and thyroid function during pregnancy: an analysis

1998 ◽  
pp. 536-542 ◽  
Author(s):  
A Berghout ◽  
W Wiersinga
Keyword(s):  
Energy Expenditure ◽  
Thyroid Function ◽  
Normal Values ◽  
Thyroid Volume ◽  
First Trimester ◽  
Normal Range ◽  
And Function ◽  
Reducing Energy ◽  
In Pregnancy ◽  
Stimulation Of

An analysis of all available studies of thyroid size and function in pregnancy reveals that thyroid size, estimated by inspection and palpation or measured more accurately by ultrasonography, increases in pregnancy in areas of iodine deficiency but not in those with sufficient iodine. The increase in average thyroid size is within the normal range, and can partly be prevented by treatment with extra iodine or thyroxine. There is a slight transient increase in free thyroxine in the first trimester, probably as a result of physiological stimulation of thyroid function by human choriogonadotrophin. These levels then decrease by about 30% to low normal values in the second and third trimesters of pregnancy in both iodine-depleted and -replete areas. These changes resemble those of non-thyroidal illness and may well play a role in reducing energy expenditure during pregnancy. The increase in thyroid size in iodine-deficient areas is probably due to autoregulatory mechanisms of iodine on thyroid growth. The hypothesis is supported by the fact that, during pregnancy, thyroid volume and thyroid function adapt in a physiological way to meet the increased demands for iodine and energy.

scholarly journals Investigating the Association of Smoking with Thyroid Volume and Function

Health ◽  
2017 ◽  
Vol 09 (13) ◽  
pp. 1843-1851
Author(s):  
Saddig Jastaniah ◽  
Amer Abed Alhazmi ◽  
Hassan Alabdullah ◽  
Faisal Fawzi Selamee ◽  
Waleed Khalid Barahim ◽  
...  
Keyword(s):  
Thyroid Volume ◽  
And Function

scholarly journals Diffuse non-toxic goiter and pregnancy

2005 ◽  
Vol 54 (1) ◽  
pp. 29-34
Author(s):  
V. V. Potine ◽  
А. В. Loginov ◽  
N. N. Tkathenko
Keyword(s):  
Thyroid Gland ◽  
Pregnant Women ◽  
Autoimmune Thyroiditis ◽  
Thyroid Volume ◽  
Percentage Increase ◽  
Free T4 ◽  
Healthy Women ◽  
Toxic Goiter ◽  
And Function ◽  
Second Degree

The aim of this study was to investigate of effect of pregnancy on the thyroid sizes and function at the patients with diffuse non-toxic goiter in a region of marginal iodine deficiency. Materials and methods: 132 pregnant women in the age of 18-39 years, including 110 with diffuse non- toxic goiter and 22 pregnant women with a normal thyroid gland, were examined. 30 patients with diffuse non-toxic goiter of the first degree received 200 мкг per day of KI (iodid- 200), 40 patients with diffuse non-toxic goiter of the second degree received a 25-75 micrograms/day thyroxine (euthyrox). 25 patients with diffuse non-toxic goiter had not received regular therapy. The autoimmune thyroiditis is revealed for 15 women with diffuse non-toxic goiter. They received a 75-100 micrograms/day euthyrox. We estimated volume of the thyroid gland by ultrasound, serum TSH and serum thyroid hormone in each trimester of pregnancy. Results: At the healthy women during pregnancy the percentage increase of volume of a thyroid gland has constituted 24,30,2%. At the patients with diffuse non-toxic goiter, not receiving therapy, the thyroid gland was authentically increased at 37,11,1%. At the pregnant women receiving iodidum the percentage increase of volume of a thyroid gland has constituted 12,30,7%. After of a euthyrox therapy there was a relative decrease of the thyroid volume by 13,70,5%. In the group of healthy women a TSH level has increased inconsiderable from l,30,6mU/l to l,60,2mU/l to the end of pregnancy. During pregnancy in the group of women with diffuse non-toxic goiter without treatment rising the TSH values in a blood from l,40,3mU/I to 2,30,2 mU/l was revealed. The mean TSH levels of the goitrous pregnant group, receiving iodidum, essentially did not vary during pregnancy. In the goitrous pregnant group, receiving euthyrox, a TSH level has decreased considerably from l,80,5mU/l to 0,60,2 mU/l to the end of pregnancy. TSH values and free T4 in all the pregnant women were within the reference range in a blood of the healthy nonpregnant women. Was not observed of differences of pregnancy course and term delivery in compared groups. The high frequency of complications of pregnancy is connected to availability of the not diagnosed autoimmune thyroiditis. Conclusion: These results recommend to usage of iodine at the women with a not enlarged thyroid gland and with diffuse non-toxic goiter of the first degree and nonsupressic doses of thyroxine at the women with diffuse non-toxic goiter of the second degree during pregnancy.

The effect of including other psychotropic medications into a long-term bipolar disorder lithium treatment on thyroid function

2019 ◽  
Vol 35 (2) ◽  
pp. 111-119
Author(s):  
Agnieszka Kraszewska ◽  
Ewa Ferensztajn-Rochowiak ◽  
Janusz Rybakowski
Keyword(s):  
Bipolar Disorder ◽  
Lithium Treatment ◽  
Antidepressant Drugs ◽  
Thyroid Volume ◽  
Thyroid Stimulating Hormone ◽  
Structure And Function ◽  
Thyroid Peroxidase ◽  
Free Triiodothyronine ◽  
And Function

Background/Aims. Long-term bipolar disorder (BD) treatment with lithium exerts a significant effect on thyroid structure and function. Compared with BD patients who do not take lithium, patients treated with lithium have higher concentrations of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), lower concentrations of free triiodothyronine (FT3), higher thyroid volume and higher occurrence of goitre. The aim of the study was to compare thyroid structure and function in relation to the inclusion of other mood stabilisers and antidepressants into a lithium treatment. Method. The studied group consisted of eighty BD patients (27 male, 53 female) aged 24–85 years, receiving a prophylactic lithium treatment for the average of 19 ± 9 years. Fifteen patients underwent lithium monotherapy; in 17, lithium was administered concurrently with carbamazepine; in 17, concurrently with quetiapine; and in 11, concurrently with valproate. In 20 subjects, lithium was administered concurrently with antidepressants. Results. In comparison with patients on lithium monotherapy, in patients who took lithium and antidepressant drugs, the concentrations of TSH were significantly higher, while in patients who took lithium and carbamazepine the concentrations of FT4 were lower. The concentrations of thyroid peroxidase antibodies (TPOAb) were significantly higher in patients who took lithium concurrently with antidepressants and concurrently with valproate. The highest frequency of goitre (70%) was observed in patients who took lithium concurrently with antidepressants. Conclusions. The obtained results may suggest a significant effect of including other mood stabilisers and antidepressants into a long-term lithium treatment on thyroid structure and function. A limitation of the study is the small size of the groups.

The effect of long-term lithium administration on thyroid function and structure as compared with monotherapy by other mood stabilising drugs – a preliminary study

2020 ◽  
Vol 35 (3-4) ◽  
pp. 169-176
Author(s):  
Agnieszka Kraszewska ◽  
Ewa Ferensztajn-Rochowiak ◽  
Janusz Rybakowski
Keyword(s):  
Antidepressant Drugs ◽  
Thyroid Volume ◽  
Thyroid Stimulating Hormone ◽  
Structure And Function ◽  
Thyroid Peroxidase ◽  
Free Triiodothyronine ◽  
Long Term Treatment ◽  
Preliminary Study ◽  
And Function

Aims: Long-term treatment with lithium in patients with bipolar disorder (BD) exerts a significant effect on thyroid structure and function. Previously, it was found that adding to lithium other mood stabilising or antidepressant drugs can also be important. The aim of this preliminary study was to compare thyroid structure and function in patients with BD receiving long-term lithium monotherapy with monotherapy using other mood stabilising drugs, such as carbamazepine, valproates or quetiapine. Method: Forty-one BD patients were studied (13 male, 28 female) aged 28–80 years. In 15, monotherapy with lithium was given; in 10 – with carbamazepine; and in 8 – with valproate and quetiapine. In all patients, the thyroid-stimulating hormone (TSH), free thyroxine (fT3) free triiodothyronine (fT4), and the antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb) and TSH receptors (TSHRAb) were estimated. Goiter was diagnosed when the thyroid volume exceeded 18 cm3 in women and 25 cm3 in men. Results: The groups were of similar age; however, the duration of quetiapine therapy was shorter than lithium or carbamazepine. Comparing to patients on lithium monotherapy, the median of TSH concentration was lower in patients on quetiapine, and the median of TPOAB lower in patients on valproates. The highest frequency of goiter (47%) was observed in patients receiving lithium. Conclusions: The results obtained may suggest that among the studied mood stabilisers, lithium exerts the biggest goiter-inducing effect. The differences between groups as to thyroid hormones and antibodies were not significant. The limitation of the study was a small number of studied patients.

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