scholarly journals Thyroid Morphology and Function in Adults with Untreated Isolated Growth Hormone Deficiency

2006 ◽  
Vol 91 (3) ◽  
pp. 860-864 ◽  
Author(s):  
Marta Regina Silva Alcântara ◽  
Roberto Salvatori ◽  
Paula Regina Silva Alcântara ◽  
Luciana Michele A. Nóbrega ◽  
Vera Simone Campos ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Thyroid Volume ◽  
Normal Subjects ◽  
Serum Levels ◽  
Hormone Deficiency ◽  
Homozygous Mutation ◽  
Free T4 ◽  
Thyroid Morphology ◽  
The Difference ◽  
And Function

Abstract Objective: GH influences thyroid function and anatomy. Although goiter is frequent in acromegalic patients, the effects of GH deficiency (GHD) are difficult to assess, because hypopituitaric subjects who lack GH often also have a partial or complete deficit of TSH. Study Design: We studied thyroid morphology and serum levels of thyroid hormones in adult members of a large Brazilian kindred with untreated isolated GHD due to a homozygous mutation in the GHRH receptor gene (GHRHR; nine men and 15 women; GHD group) and compared them to subjects heterozygous for the same mutation (eight men and 10 women; HET group) and subjects homozygous for the wild-type allele [seven men and 11 women; control (CO) group]. Results: GHD subjects had a smaller thyroid volume (TV) than HET and CO. The TV of the HET group was intermediate between those of the GHD and CO groups. When TV was corrected by body surface area, it remained smaller in the GHD and HET groups than in the CO group, but the difference between GHD and HET groups disappeared. The GHD group had lower serum T3 levels than the CO group and higher free T4 levels than HET and CO groups. Conclusions: Individuals with severe untreated GHD due to a homozygous GHRHR mutation and heterozygous carriers of the same mutation have smaller TV than normal subjects, suggesting that GH has a permissive role in the growth of the thyroid gland. In addition, GHD subjects have reduced serum total T3 and increased serum free T4, suggesting a reduction in the function of the deiodinase system.

scholarly journals Lack of Association between the Trp64Arg Mutation in the β3-Adrenergic Receptor Gene and Obesity in Japanese Men: A Longitudinal Analysis

1997 ◽  
Vol 82 (4) ◽  
pp. 1284-1287 ◽  
Author(s):  
Terumasa Nagase ◽  
Akira Aoki ◽  
Michiko Yamamoto ◽  
Hiroko Yasuda ◽  
Seijiro Kado ◽  
...  
Keyword(s):  
Body Weight ◽  
Adrenergic Receptor ◽  
Receptor Gene ◽  
Adult Life ◽  
Dependent Diabetes Mellitus ◽  
Heterozygous Mutation ◽  
Homozygous Mutation ◽  
Japanese Men ◽  
The Difference ◽  
Adrenergic Receptor Gene

Abstract The β3-adrenergic receptor (β3AR) is implicated in the regulation of thermogenesis and lipolysis, and it is suggested that the Trp64Arg mutation in this receptor may contribute to the development of obesity. To examine whether the Trp64Arg mutation had any effect on body weight during adult life, the β3AR genotype was determined in 186 unselected Japanese men, most of whom had records of body weight measured yearly from 25–53 yr of age. Of them, 26 subjects were diagnosed as having noninsulin-dependent diabetes mellitus (NIDDM) and 41 as having impaired glucose tolerance. There were 6 subjects (3%) with homozygous mutation, 67 (36%) with heterozygous mutation, and 113 (61%) with normal allele. Among the 3 genotypes, there were no significant differences in body mass index (BMI) at any age between 25–53 yr and the prevalence of NIDDM at the age of 53 yr. When longitudinal changes in body weight were compared between subjects with and without mutation, the former were less prone to gain weight than the latter. The frequency of the mutant allele was 1) not different among obese (BMI, >26.4), intermediate (BMI, 22–26.4), and nonobese (BMI, <22.0) subjects (0.21, 0.22, and 0.26, respectively; P = 0.77); 2) lower in subjects with NIDDM than in those without it, but the difference was insignificant (0.12 vs. 0.23; P = 0.07); and 3) similar between 186 unselected men and another group of 100 patients with NIDDM that were randomly selected for comparison (0.21 vs. 0.23). These results suggest that the β3AR is not a major contributing factor to obesity or NIDDM in Japanese men.

scholarly journals Diffuse non-toxic goiter and pregnancy

2005 ◽  
Vol 54 (1) ◽  
pp. 29-34
Author(s):  
V. V. Potine ◽  
А. В. Loginov ◽  
N. N. Tkathenko
Keyword(s):  
Thyroid Gland ◽  
Pregnant Women ◽  
Autoimmune Thyroiditis ◽  
Thyroid Volume ◽  
Percentage Increase ◽  
Free T4 ◽  
Healthy Women ◽  
Toxic Goiter ◽  
And Function ◽  
Second Degree

The aim of this study was to investigate of effect of pregnancy on the thyroid sizes and function at the patients with diffuse non-toxic goiter in a region of marginal iodine deficiency. Materials and methods: 132 pregnant women in the age of 18-39 years, including 110 with diffuse non- toxic goiter and 22 pregnant women with a normal thyroid gland, were examined. 30 patients with diffuse non-toxic goiter of the first degree received 200 мкг per day of KI (iodid- 200), 40 patients with diffuse non-toxic goiter of the second degree received a 25-75 micrograms/day thyroxine (euthyrox). 25 patients with diffuse non-toxic goiter had not received regular therapy. The autoimmune thyroiditis is revealed for 15 women with diffuse non-toxic goiter. They received a 75-100 micrograms/day euthyrox. We estimated volume of the thyroid gland by ultrasound, serum TSH and serum thyroid hormone in each trimester of pregnancy. Results: At the healthy women during pregnancy the percentage increase of volume of a thyroid gland has constituted 24,30,2%. At the patients with diffuse non-toxic goiter, not receiving therapy, the thyroid gland was authentically increased at 37,11,1%. At the pregnant women receiving iodidum the percentage increase of volume of a thyroid gland has constituted 12,30,7%. After of a euthyrox therapy there was a relative decrease of the thyroid volume by 13,70,5%. In the group of healthy women a TSH level has increased inconsiderable from l,30,6mU/l to l,60,2mU/l to the end of pregnancy. During pregnancy in the group of women with diffuse non-toxic goiter without treatment rising the TSH values in a blood from l,40,3mU/I to 2,30,2 mU/l was revealed. The mean TSH levels of the goitrous pregnant group, receiving iodidum, essentially did not vary during pregnancy. In the goitrous pregnant group, receiving euthyrox, a TSH level has decreased considerably from l,80,5mU/l to 0,60,2 mU/l to the end of pregnancy. TSH values and free T4 in all the pregnant women were within the reference range in a blood of the healthy nonpregnant women. Was not observed of differences of pregnancy course and term delivery in compared groups. The high frequency of complications of pregnancy is connected to availability of the not diagnosed autoimmune thyroiditis. Conclusion: These results recommend to usage of iodine at the women with a not enlarged thyroid gland and with diffuse non-toxic goiter of the first degree and nonsupressic doses of thyroxine at the women with diffuse non-toxic goiter of the second degree during pregnancy.

scholarly journals Clinical, Hormonal, and Ultrasound Characteristics of Patients with Newly Diagnosed Graves’ Disease And Different Thyroid Antibody Profiles

2019 ◽  
Vol 46 (2) ◽  
pp. 5-12 ◽  
Author(s):  
R. Mekova ◽  
M. Boyanov
Keyword(s):  
Thyroid Volume ◽  
Serum Levels ◽  
Thyroid Peroxidase ◽  
Graves Disease ◽  
Clinical Approach ◽  
Newly Diagnosed ◽  
Free T4 ◽  
Thyroid Antibody ◽  
Different Characteristics ◽  
Roche Diagnostics

Abstract Objective: Graves’ disease (GD) is characterized by elevated TSH-receptor antibodies (TRAb) and less often – thyroid peroxidase (TPOAb) and thyroglobulin antibodies (TgAb). Our aim was to examine the hormonal and ultrasound characteristics of patients with newly diagnosed GD with differing positive thyroid antibodies. Materials and Methods: This study included 249 patients with newly diagnosed GD (191 women, 58 men). 40.2% of them had Graves’ ophtalmopathy. The serum levels of TSH, free T4, free T3, TRAb, TPOAb, and TgAb were measured with third generation ECLIA assays (Roche Diagnostics, Switzerland). Thyroid ultrasound was performed with a Fukuda-Denshi 550 device (Fukuda Corp., Japan) and an Ultrasonix device (Ultrasonix Medical Corp., Canada). Statistical analyses were done using the SPSS 23.0 statistical package (Chicago, IL). Results: 64% of the patients were TPOAb+ and 36% − TgAb+. One third were only TRAb+, 1/3 had two positive antibodies (TRAb + second antibody) and 1/3 – all three positive antibodies. Patients with more positive antibodies tended to be younger, had higher fT4, TRAb levels, thyroid volume but rarely had nodules on US and accompanying GO. Positive TPOAb antibodies were found in younger patients, with higher fT4 and TRAb levels, higher thyroid volume and lower prevalence of nodules and GO. The same trends were found in patients with positive TgAb. Conclusion: The different characteristics of GD patients with varying thyroid antibody profiles may be due to a variation in the pathogenesis of the disease. An individualized clinical approach may be suitable in those cases.

scholarly journals Adipokine Profile and Urinary Albumin Excretion in Isolated Growth Hormone Deficiency

2010 ◽  
Vol 95 (2) ◽  
pp. 693-698 ◽  
Author(s):  
Carla R. P. Oliveira ◽  
Roberto Salvatori ◽  
Rafael A. Meneguz-Moreno ◽  
Manuel H. Aguiar-Oliveira ◽  
Rossana M. C. Pereira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Urinary Albumin Excretion ◽  
Receptor Gene ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Urinary Albumin ◽  
Hormone Deficiency ◽  
Cross Sectional ◽  
Albumin Excretion ◽  
Reactive Protein

Abstract Background: GH deficiency (GHD) is often associated with cardiovascular risk factors, including abdominal fat accumulation, hypercholesterolemia, and increased C-reactive protein. Despite the presence of these risk factors, adults with congenital lifetime isolated GHD (IGHD) due to an inactivating mutation in the GHRH receptor gene do not have premature atherosclerosis. Objective: The aim was to study the serum levels of adiponectin and leptin (antiatherogenic and atherogenic adipokine, respectively), and the urinary albumin excretion (UAE) in these IGHD individuals. Design and Patients: We conducted a cross-sectional study of 20 IGHD individuals (seven males; age, 50.8 ± 14.6 yr) and 22 control subjects (eight males; age, 49.9 ± 11.5 yr). Main Outcome Measures: Anthropometric factors, body composition, blood pressure, serum adiponectin, leptin, and UAE were measured. Results: Adiponectin was higher [12.8 (7.1) vs. 9.7 (5) ng/ml; P = 0.041] in IGHD subjects, whereas no difference was observed in leptin [7.3 (6.3) vs. 9.3 (18.7 ng/ml] and UAE [8.6 (13.8) vs. 8.5 (11.1) μg/min]. Conclusions: Subjects with lifetime untreated IGHD have an adipokine profile with high adiponectin and normal leptin levels that may delay vascular damage and lesions of the renal endothelium.

scholarly journals Longevity in Untreated Congenital Growth Hormone Deficiency Due to a Homozygous Mutation in the GHRH Receptor Gene

2010 ◽  
Vol 95 (2) ◽  
pp. 714-721 ◽  
Author(s):  
Manuel H. Aguiar-Oliveira ◽  
Francielle T. Oliveira ◽  
Rossana M. C. Pereira ◽  
Carla R. P. Oliveira ◽  
Amanda Blackford ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Receptor Gene ◽  
Hormone Deficiency ◽  
Homozygous Mutation ◽  
Ghrh Receptor

IL-10-592 A/C Gene Polymorphism and Cytokine Levels are Associated with Susceptibility to Drug Resistance in Tuberculosis

2020 ◽  
Vol 8 (3) ◽  
pp. 103-112
Author(s):  
Atefeh SADEGHI SHERMEH ◽  
Majid KHOSHMIRSAFA ◽  
Ali-Akbar DELBANDI ◽  
Payam TABARSI ◽  
Esmaeil MORTAZ ◽  
...  
Keyword(s):  
Serum Levels ◽  
World Health ◽  
Control Group ◽  
Drug Resistant ◽  
Nucleotide Polymorphisms ◽  
Genotype Frequencies ◽  
Cytokine Levels ◽  
Ifn Γ ◽  
Health Organization ◽  
And Function

Introduction: Tuberculosis (TB) and especially resistant forms of it have a substantial economic burden on the community health system for diagnosis and treatment each year. Thus, investigation of this field is a priority for the world health organization (WHO). Cytokines play important roles in the relationship between the immune system and tuberculosis. Genetic variations especially single nucleotide polymorphisms (SNPs) impact cytokine levels and function against TB. Material and Methods: In this research SNPs in IFN-γ (+874 T/A) and IL-10 (-592 A/C) genes, and the effects of these SNPs on cytokine levels in a total of 87 tuberculosis patients and 100 healthy controls (HCs) were studied. TB patients divided into two groups: 1) 67 drug-sensitive (DS-TB) and 2) 20 drug-resistant (DR-TB) according to drug sensitivity test using polymerase chain reaction (PCR). For the genotyping of two SNPs, the PCR-based method was used and IFN-γ and IL-10 levels were measured by ELISA in pulmonary tuberculosis (PTB) and control group. Results: In -592A/C SNP, only two genotypes (AA, AC) were observed and both genotypes showed statistically significant differences between DR-TB and HCs (p=0.011). IL-10 serum levels in PTB patients were higher than HCs (p=0.02). The serum levels of IFN-γ were significantly higher in DS-TB patients than that of the other two groups (p<0.001); however, no significant differences were observed for allele and genotype frequencies in IFN-γ +874. Conclusions: Our results suggest that the SNP at -592 position of IL-10 gene may be associated with the susceptibility to DR-TB. However, further investigation is necessary. Keywords: Polymorphism, IFN-γ, IL-10, tuberculosis, drug-resistant tuberculosis

Sign in / Sign up

Export Citation Format

Share Document