Effects of free fatty acids on insulin secretion in obesity

2002 ◽  
Vol 3 (2) ◽  
pp. 103-112 ◽  
Author(s):  
S. Zraika ◽  
M. Dunlop ◽  
J. Proietto ◽  
S. Andrikopoulos
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids

scholarly journals Associations of Free Fatty Acids With Insulin Secretion and Action Among African-American and European-American Girls and Women

Obesity ◽  
2010 ◽  
Vol 18 (2) ◽  
pp. 247-253 ◽  
Author(s):  
Laura Lee T. Goree ◽  
Betty E. Darnell ◽  
Robert A. Oster ◽  
Marian A. Brown ◽  
Barbara A. Gower
Keyword(s):  
Fatty Acids ◽  
African American ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
European American

scholarly journals Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets

2006 ◽  
Vol 119 (7) ◽  
pp. 574-580 ◽  
Author(s):  
Jing-yan TIAN ◽  
Guo LI ◽  
Yan-yun GU ◽  
Hong-li ZHANG ◽  
Wen-zhong ZHOU ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
Rat Islets ◽  
Isolated Rat Islets ◽  
Isolated Rat

GLUCOSE, FREE FATTY ACIDS, AND INSULIN SECRETION

2009 ◽  
Vol 28 (4) ◽  
pp. 93-95
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids

scholarly journals Hole of plasma free fatty acids in the control of insulin secretion in man

Diabetologia ◽  
1973 ◽  
Vol 9 (2) ◽  
pp. 145-151 ◽  
Author(s):  
E. O. Balasse ◽  
H. A. Ooms
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
Plasma Free Fatty Acids

Effects of Long Chain Free Fatty Acids on Glucose-Induced Insulin Secretion in the Perfused Rat Pancreas

1993 ◽  
Vol 25 (11) ◽  
pp. 596-597 ◽  
Author(s):  
O. Mokuda ◽  
Y. Sakamoto ◽  
H.-Y. Hu ◽  
R. Kawagoe ◽  
N. Shimizu
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Long Chain

scholarly journals Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells

Diabetes ◽  
2000 ◽  
Vol 49 (5) ◽  
pp. 735-740 ◽  
Author(s):  
G. Patane ◽  
S. Piro ◽  
A. M. Rabuazzo ◽  
M. Anello ◽  
R. Vigneri ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
Beta Cells ◽  
High Glucose ◽  
Pancreatic Beta Cells ◽  
Chronic Exposure

Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from β-cells through activation of GPR40

2007 ◽  
Vol 263 (1-2) ◽  
pp. 173-180 ◽  
Author(s):  
Susanne Schnell ◽  
Michael Schaefer ◽  
Christof Schöfl
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
Free Calcium ◽  
Β Cells ◽  
Cytosolic Free Calcium ◽  
Stimulate Insulin Secretion

scholarly journals Stimulation of Insulin Secretion by Long-Chain Free Fatty Acids. A DIRECT PANCREATIC EFFECT

1973 ◽  
Vol 52 (8) ◽  
pp. 1979-1984 ◽  
Author(s):  
Stephen R. Crespin ◽  
William B. Greenough ◽  
Daniel Steinberg
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
Long Chain ◽  
Stimulation Of

Circulating lipids are lowered but pancreatic islet lipid metabolism and insulin secretion are unaltered in exercise-trained female rats

2007 ◽  
Vol 32 (2) ◽  
pp. 241-248 ◽  
Author(s):  
Julien Lamontagne ◽  
Pellegrino Masiello ◽  
Mariannick Marcil ◽  
Viviane Delghingaro-Augusto ◽  
Yan Burelle ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Free Fatty Acids ◽  
Fatty Acid Oxidation ◽  
Female Rats ◽  
Acid Oxidation ◽  
Β Cell ◽  
Glucose Stimulated Insulin Secretion

Deteriorating islet β-cell function is key in the progression of an impaired glucose tolerance state to overt type 2 diabetes (T2D), a transition that can be delayed by exercise. We have previously shown that trained rats are protected from heart ischemia–reperfusion injury in correlation with an increase in cardiac tissue fatty-acid oxidation. This trained metabolic phenotype, if induced in the islet, could also prevent β-cell failure in the pathogenesis of T2D. To assess the effect of training on islet lipid metabolism and insulin secretion, female Sprague–Dawley rats were exercised on a treadmill for 90 min/d, 4 d/week, for 10 weeks. Islet fatty-acid oxidation, the expression of key lipid metabolism genes, and glucose-stimulated insulin secretion were determined in freshly isolated islets from trained and sedentary control rats after a 48 h rest period from the last exercise. Although this moderate training reduced plasma glycerol, free fatty acids, and triglyceride levels by about 40%, consistent with reduced lipolysis from adipose tissue, it did not alter islet fatty-acid oxidation, nor the islet expression of key transcription factors and enzymes of lipid metabolism. The training also had no effect on glucose-stimulated insulin secretion or its amplification by free fatty acids. In summary, chronic exercise training did not cause an intrinsic change in islet lipid metabolism. Training did, however, substantially reduce the exposure of islets to exogenous lipid, thereby providing a potential mechanism by which exercise can prevent islet β-cell failure leading to T2D.

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