Novel approach to the analysis and synthesis of modulation processes in power convertors

1975 ◽  
Vol 122 (5) ◽  
pp. 507 ◽  
Author(s):  
S.R. Bowes ◽  
B.M. Bird
Keyword(s):  
Novel Approach ◽  
Analysis And Synthesis

scholarly journals Directed Reachability for Infinite-State Systems

2021 ◽  
pp. 3-23
Author(s):  
Michael Blondin ◽  
Christoph Haase ◽  
Philip Offtermatt
Keyword(s):  
Petri Nets ◽  
Program Analysis ◽  
Infinite Graphs ◽  
Reachability Problem ◽  
Graph Exploration ◽  
Concurrent Program ◽  
Domain Specific ◽  
Novel Approach ◽  
Distance Oracles ◽  
Analysis And Synthesis

AbstractNumerous tasks in program analysis and synthesis reduce to deciding reachability in possibly infinite graphs such as those induced by Petri nets. However, the Petri net reachability problem has recently been shown to require non-elementary time, which raises questions about the practical applicability of Petri nets as target models. In this paper, we introduce a novel approach for efficiently semi-deciding the reachability problem for Petri nets in practice. Our key insight is that computationally lightweight over-approximations of Petri nets can be used as distance oracles in classical graph exploration algorithms such as $$\mathsf {A}^{*}$$ A ∗ and greedy best-first search. We provide and evaluate a prototype implementation of our approach that outperforms existing state-of-the-art tools, sometimes by orders of magnitude, and which is also competitive with domain-specific tools on benchmarks coming from program synthesis and concurrent program analysis.

scholarly journals A NOVEL APPROACH TO STUTTERED SPEECH CORRECTION

2016 ◽  
Vol 9 (2) ◽  
pp. 80 ◽  
Author(s):  
Alim Sabur Ajibola ◽  
Nahrul Khair Bin Alang Md. Rashid ◽  
Wahju Sediono ◽  
Nik Nur Wahidah Nik Hashim
Keyword(s):  
Mean Square Error ◽  
Likelihood Ratio ◽  
Mean Square ◽  
Novel Approach ◽  
Three Samples ◽  
Reconstruction Quality ◽  
Analysis And Synthesis ◽  
Original Speech ◽  
Speech Reconstruction ◽  
Speech Correction

Stuttered speech is a dysfluency rich speech, more prevalent in males than females. It has been associated with insufficient air pressure or poor articulation, even though the root causes are more complex. The primary features include prolonged speech and repetitive speech, while some of its secondary features include, anxiety, fear, and shame. This study used LPC analysis and synthesis algorithms to reconstruct the stuttered speech. The results were evaluated using cepstral distance, Itakura-Saito distance, mean square error, and likelihood ratio. These measures implied perfect speech reconstruction quality. ASR was used for further testing, and the results showed that all the reconstructed speech samples were perfectly recognized while only three samples of the original speech were perfectly recognized.

scholarly journals ABSTRACT PHYSICS REPRESENTATION OF A BALANCED TWO-WHEEL SCOOTER IN GRAPH-BASED DESIGN LANGUAGES

2020 ◽  
Vol 1 ◽  
pp. 1057-1066 ◽  
Author(s):  
M. Ramsaier ◽  
R. Stetter ◽  
M. Till ◽  
S. Rudolph
Keyword(s):  
The Novel ◽  
Level Of Abstraction ◽  
Important Link ◽  
Novel Approach ◽  
Analysis And Synthesis ◽  
Design Languages ◽  
Technical Systems ◽  
Physical Phenomena ◽  
Holistic Description ◽  
Digital Engineering

AbstractThis paper presents a novel approach to include a holistic description of abstract physics in a digital engineering framework. Physical phenomena realize the numerous functions of technical systems and are an important link between rather abstract product functions and the concrete product geometry and material. Until now, a possibility to integrate the analysis and synthesis on this level of abstraction into a holistic engineering frameworks is not existing. The novel approach employs graph-based design languages using UML for this endeavour; the product example is a two-wheel scooter.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

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