scholarly journals Compositional and micromorphological features of hypoplastic enamel in children’s permanent teeth

2020 ◽  
Vol 22 ◽  
pp. 02013
Author(s):  
Natalya Ozhgikhina ◽  
Daria Kiseleva ◽  
Evgeny Shagalov ◽  
Evgenia Bimbas ◽  
Natalya Myagkova
Keyword(s):  
Protein Structures ◽  
Clinical Manifestations ◽  
Local Environment ◽  
Comparative Investigation ◽  
Permanent Teeth ◽  
Common Disease ◽  
Enamel Hypoplasia ◽  
Globular Structure ◽  
Prismatic Structure ◽  
Irregular Structure

Enamel hypoplasia is the most common disease of hard tooth tissues of non-carious origin emerging before their eruption. It develops as a result of a delayed and perverse function of ameloblasts leading to the violation of the processes of formation and mineralization of tooth protein structures. The clinical manifestations of enamel hypoplasia are spots, defects in the form of pits, cup-shaped depressions, grooves on various surfaces of child’s teeth. The work is devoted to a comparative investigation of microstructural and compositional features of intact and hypoplastic enamel in children’s permanent teeth using analytical scanning electron microscopy with energy-dispersive X-ray spectroscopy. The hypoplastic enamel is enriched in organic substance and has an irregular structure without keyhole-shaped prismatic structure. Mineral deposition is indicated for hypoplastic enamel including hydroxyapatite with globular structure and calcite and halite, which might have been caused by the violation of extracellular local environment probably due to the enamel hypoplasia development.

Tetracycline syrups and children’s teeth

1984 ◽  
Vol 22 (14) ◽  
pp. 55-56
Keyword(s):  
At Risk ◽  
In Utero ◽  
Permanent Teeth ◽  
Deciduous Teeth ◽  
Enamel Hypoplasia ◽  
Yellow Colour ◽  
Paediatric Patients ◽  
Short Course

It has been known for over 25 years that treatment with oral tetracyclines can permanently stain children’s teeth1 yet these drugs are still needlessly being prescribed for children. In 1982 over 75,000 prescriptions for a liquid tetracycline preparation were dispensed, most of which were probably for children; up to one third of paediatric patients have been affected,2–6 although the proportion has fallen over the last 10 years.7 Even a short course of tetracycline can stain both the permanent3,8 and deciduous teeth9 a disfiguring greyish-brown or yellow colour. Children are at risk from the 14th week in utero, when calcification of deciduous teeth begins, to their 7th year when calcification of the permanent teeth is complete. Whether tetracyclines produce enamel hypoplasia10 or promote caries11 is disputed.12

scholarly journals Frequency and chronological distribution of linear enamel hypoplasia (LEH) in the Late Neolithic and Early Bronze Age population from Żerniki Górne (Poland) – preliminary report

2012 ◽  
Vol 75 (1) ◽  
pp. 61-73 ◽  
Author(s):  
Jacek Tomczyk ◽  
Maria Tomczyk-Gruca ◽  
Marta Zalewska
Keyword(s):  
Bronze Age ◽  
Physiological Stress ◽  
Economic Status ◽  
Permanent Teeth ◽  
Early Bronze Age ◽  
Enamel Hypoplasia ◽  
Late Neolithic ◽  
Linear Enamel Hypoplasia ◽  
Tool Stress ◽  
Health Related

Abstract Linear enamel hypoplasia (LEH) is treated as a nonspecific indicator of stress, but even so, many authors consider it the most reliable tool stress in anthropological research. Its analysis allows the reconstruction of health related to the socio-economic status of the group. This study documents and interprets patterns of LEH in Żerniki Górne (Poland), a settlement which was functional in the Late Neolithic and the Early Bronze Age. We examined two successive cultures: the Corded Ware Culture (CWC; 3200-2300BC) and the Trzciniec Culture (TC; 1500-1300BC). In total, there were 1486 permanent teeth (124 adult individuals). The frequency of LEH in the examined cultures shows a small rising trend. In these series from Żernik Górne, males showed a higher occurrence of LEH (16.5%) than females (13.4%). The earliest LEH appeared at similar ages at about 2.0/2.2 years and the last LEH occurred at about 4.2 years of age in both cultures. However, it is worth noting that periods associated with physiological stress were more common but not very long (four months on average) in the CWC. Longer stress periods (nine months on average) were associated with the TC.

scholarly journals Case Report of Isolated Hepatic Tuberculosis

2015 ◽  
Vol 26 (1) ◽  
pp. 43-45 ◽  
Author(s):  
Mohammad Rafiqul Islam ◽  
Maria Maksud ◽  
Prianka Baral ◽  
Mahbub Hossain ◽  
Ahmedul Kabir
Keyword(s):  
Case Report ◽  
Clinical Manifestations ◽  
Common Disease ◽  
Pulmonary Tb ◽  
Common Diseases ◽  
Hepatic Tuberculosis ◽  
History Of ◽  
Space Occupying Lesion

Tuberculosis is one of the most common diseases in Bangladesh and has variable clinical manifestations. Isolated Hepatic tuberculosis is not a common disease; in fact the presentation of hepatic tuberculosis may be without having history of any active Pulmonary TB or military TB. Patient usually present without having any typical symptoms; so it is difficult for a physician to diagnose the disease quickly. Patient presenting with space occupying lesion in liver is confused with abscess, hepatoma or metastases. Here we are presenting a case report of isolated hepatic tuberculosis.Bangladesh J Medicine Jan 2015; 26 (1) : 43-45

scholarly journals ENAMEL HYPOPLASIA (EH) OF PERMANENT TEETH IN COELIAC DISEASE (CD)

1986 ◽  
Vol 20 (7) ◽  
pp. 696-696
Author(s):  
L Aine ◽  
M Mäki ◽  
E Aine ◽  
J K Visakorpi
Keyword(s):  
Coeliac Disease ◽  
Permanent Teeth ◽  
Enamel Hypoplasia

scholarly journals Leptospirosis presented with erythema nodosum on four limbs: an unusual presenting

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Lotfollah Davoodi ◽  
Armaghan Kazeminejad ◽  
Hamed Jafarpour ◽  
Alireza Razavi
Keyword(s):  
Rare Case ◽  
Erythema Nodosum ◽  
Clinical Manifestations ◽  
Common Disease ◽  
Clinical Form ◽  
Case Presentation ◽  
Typical Form ◽  
Wide Range ◽  
Adipose Inflammation ◽  
Subcutaneous Adipose

Abstract Leptospirosis is a common disease between humans and animals characterized by a wide range of clinical manifestations. Erythema nodosum (EN) is a common clinical form of panniculitis or subcutaneous adipose inflammation caused by hypersensitivity responses to antigens, but the presence of EN in a subject with leptospirosis is a very rare case presentation. We will present a 42-year-old man with a headache, myalgia, nausea and rigid tender on the shin and both forearms, which was a typical form of EN lesions.

Novel and Recurring NOTCH3 Mutations in Two Chinese Patients with CADASIL

2019 ◽  
Vol 19 (1) ◽  
pp. 35-42
Author(s):  
Xiangyu Chen ◽  
Sheng Deng ◽  
Hongbo Xu ◽  
Deren Hou ◽  
Pengzhi Hu ◽  
...  
Keyword(s):  
Autosomal Dominant ◽  
Novel Mutation ◽  
Clinical Manifestations ◽  
Han Chinese ◽  
Notch Receptor ◽  
Chinese Patients ◽  
Common Disease ◽  
Common Mutation ◽  
Notch3 Gene ◽  
Genetic Causes

Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal-dominant, inherited, systemic, vascular disorder primarily involving the small arteries. It is characterized by migraine, recurrent ischemic strokes, cognitive decline, and dementia. Mutations in the Notch receptor 3 gene (NOTCH3) and the HtrA serine peptidase 1 gene (HTRA1) are 2 genetic causes for CADASIL. The NOTCH3 gene, located on chromosome 19p13.12, is the most common disease-causing gene in CADASIL. Objective: To investigate genetic causes in 2 unrelated Han-Chinese patients with presentations strongly suggestive of CADASIL. Methods: Exome sequencing was performed on both patients and potential pathogenic mutations were validated by Sanger sequencing. Results: This study reports on 2 unrelated Han-Chinese patients with presentations strongly suggestive of CADASIL, identifying that NOTCH3 mutations were the genetic cause. A common mutation, c.268C>T (p.Arg90Cys), and a novel mutation, c.331G>T (p.Gly111Cys) in the NOTCH3 gene, were detected and confirmed in the patients, respectively, and were predicted to be deleterious based on bioinformation analyses. Conclusions: We identified 2 NOTCH3 mutations as likely genetic causes for CADASIL in these 2 patients. Our findings broaden the mutational spectrum of the NOTCH3 gene accountable for CADASIL. Clinical manifestations supplemented with molecular genetic analyses are critical for accurate diagnosis, the provision of genetic counseling, and the development of therapies for CADASIL.

Hypohidrotic ectodermal dysplasia: dental, clinical, genetic and dermatoglyphic findings of three cases

2002 ◽  
Vol 26 (1) ◽  
pp. 5-12 ◽  
Author(s):  
B. Kargül ◽  
T. Alcan ◽  
U. Kabalay ◽  
M. Atasu
Keyword(s):  
Ectodermal Dysplasia ◽  
Oral Surgery ◽  
Clinical Manifestations ◽  
Pediatric Dentistry ◽  
Permanent Teeth ◽  
Maxillofacial Radiology ◽  
Hypohidrotic Ectodermal Dysplasia ◽  
Clinical Genetic ◽  
Osseointegrated Implants ◽  
Removable Prosthesis

Patients with hypohidrotic ectodermal dysplasia (HED) are characterized by the clinical manifestations of hypodontia, hypohidrosis, hypotrichosis and a highly characteristic facial physiognomy. This disorder is inherited as an X- linked trait. This report presents three cases with HED in which the clinical evaluation (intraoral and radiological), genetic findings and SEM examination of hair. Boys 6 to 14 year old and a 11 year old girl were referred to the Marmara University, Faculty of Dentistry, complaining of oligodontia in the maxillary and mandibular arches and delay in eruption of other teeth. Peg-shaped teeth have been observed. The dermatoglyphs of the patients were striking. SEM exmimation of hair demostrated a distinctly abnormal longitudinal groving along the entire length of each hair and a desquamation of the surface cuticles. The treatment was planned in a multidisciplinary odontological group involving pediatric dentistry, orthodontics, prosthodontics and oral surgery and maxillofacial radiology of future dental habilitation. A specially designed overdenture, a removable prosthesis and osseointegrated implants were constructed. Periodic recall visits were advised, to monitor the dentures and implants during periods of growth and development, and eruption of the permanent teeth.

scholarly journals Dental Anomalies in Permanent Teeth after Trauma in Primary Dentition

2017 ◽  
Vol 41 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Elena Bardellini ◽  
Francesca Amadori ◽  
Stefania Pasini ◽  
Alessandra Majorana
Keyword(s):  
Retrospective Study ◽  
Study Design ◽  
Primary Teeth ◽  
Primary Dentition ◽  
Permanent Teeth ◽  
Dental Anomalies ◽  
Enamel Hypoplasia ◽  
White Spots ◽  
The Status

Objective: This retrospective study aims to evaluate the prevalence of dental anomalies in permanent teeth as a result of a trauma concerning the predecessor primary teeth. Study design: A total of 241 records of children (118 males and 123 females, mean age 3.62 ± 1.40) affected by trauma on primary teeth were analyzed. All patients were recalled to evaluate the status of the permanent successor teeth by clinical and radiographic investigations. Results: Out of 241 patients, 106 patients (for a total of 179 traumatized primary teeth) presented at the recall. Dental anomalies on successor permanent teeth were detected in 21 patients (19.8%), for a total of 26 teeth (14.5%) and 28 anomalies. Anomalies of the eruptive process were the most observed disturbances (60.7%), followed by enamel hypoplasia (25%) and white spots (14.3%). A higher percentage of anomalies on permanent teeth was observed when trauma occurred at an age less than 36 months (38.5% of cases). Intrusive and extrusive luxation were related with the most cases of clinical disturbances in the successor permanent teeth. Conclusions: The results of this study highlight the risk of dental anomalies after a trauma in primary dentition, especially in early-aged children and in case of intrusive luxation.

scholarly journals Toxocariasis: Clinical Aspects, Epidemiology, Medical Ecology, and Molecular Aspects

2003 ◽  
Vol 16 (2) ◽  
pp. 265-272 ◽  
Author(s):  
Dickson Despommier
Keyword(s):  
Clinical Manifestations ◽  
Local Environment ◽  
Nematode Species ◽  
Larva Migrans ◽  
Clinical Aspects ◽  
Urban Centers ◽  
Larval Stages ◽  
Health Initiatives ◽  
Molecular Aspects ◽  
And Control

SUMMARY Toxocariasis is caused by a series of related nematode species (ascarids) that routinely infect dogs and cats throughout the world. The eggs from these ascarids are common environmental contaminants of human habitation, due largely to the fact that many kinds of dogs and cats serve as pets, while countless others run wild throughout the streets of most urban centers. The eggs, present in dog and cat feces, become infectious within weeks after they are deposited in the local environment (e.g., sandboxes, city parks, and public beaches, etc.). Humans, particularly children, frequently ingest these eggs by accident and become infected. Infection in humans, in contrast to their definitive hosts, remains occult, often resulting in disease caused by the migrating larval stages. Visceral larva migrans (VLM) and ocular larva migrans (OLM) are two clinical manifestations that result in definable syndromes and present as serious health problems wherever they occur. Diagnosis and treatment of VLM and OLM are difficult. These issues are summarized in this review, with emphasis on the ecology of transmission and control of spread to both humans and animals through public health initiatives employing treatment of pets and environmental intervention strategies that limit the areas that dogs and cats are allowed within the confines of urban centers.

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