scholarly journals Case Report of Isolated Hepatic Tuberculosis

2015 ◽  
Vol 26 (1) ◽  
pp. 43-45 ◽  
Author(s):  
Mohammad Rafiqul Islam ◽  
Maria Maksud ◽  
Prianka Baral ◽  
Mahbub Hossain ◽  
Ahmedul Kabir
Keyword(s):  
Case Report ◽  
Clinical Manifestations ◽  
Common Disease ◽  
Pulmonary Tb ◽  
Common Diseases ◽  
Hepatic Tuberculosis ◽  
History Of ◽  
Space Occupying Lesion

Tuberculosis is one of the most common diseases in Bangladesh and has variable clinical manifestations. Isolated Hepatic tuberculosis is not a common disease; in fact the presentation of hepatic tuberculosis may be without having history of any active Pulmonary TB or military TB. Patient usually present without having any typical symptoms; so it is difficult for a physician to diagnose the disease quickly. Patient presenting with space occupying lesion in liver is confused with abscess, hepatoma or metastases. Here we are presenting a case report of isolated hepatic tuberculosis.Bangladesh J Medicine Jan 2015; 26 (1) : 43-45

scholarly journals Diagnosis Based on Detection of CXCL10 in Urine as Biomarker for The Determining Diagnosis of Active Lung Tuberculosis

2021 ◽  
Vol 9 (1) ◽  
pp. 57
Author(s):  
Ni Made Mertaniasih ◽  
I Gede Yogi Prema Ananda ◽  
Soedarsono Soedarsono ◽  
Deby Kusumaningrum
Keyword(s):  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Urine Samples ◽  
Laboratory Research ◽  
Future Research ◽  
Cross Sectional ◽  
Pulmonary Tb ◽  
Lung Tuberculosis ◽  
History Of ◽  
Tuberculosis Diagnosis

Tuberculosis diagnosis is an important component in decreasing TB incidence and prevalence. Because of the difficulty to collect sputum in some cases, urine specimens are used as it is easier to garner. One of the biomarkers in urine that can be used to diagnose pulmonary TB is IP-10, which can be represented by the CXCL10 gene. The study aims to determine the accuracy of diagnosis based on detection of the CXCL10 gene in urine as a biomarker for the patients with suspected pulmonary TB in Dr. Soetomo Hospital in Surabaya from November 2019 until March 2020. Thus, this is an observative laboratory research with a cross-sectional study. CXCL10 gene was examined using PCR for 36 urine samples, and then, the data, together with the medical records of clinical manifestations of pulmonary TB, GeneXpert MTB /RIF, blood count, and thorax radiograph, were processed using IBM SPSS Statistics 26. The results of the GeneXpert MTB/RIF and thorax radiograph criteria show positive results of pulmonary TB, which were 44.4% and 69.4% respectively. CXCL10 gene was not found in all urine of healthy people (negative), while 2.8% (1/36 samples) positive CXCL10 gene was found in a patient with positive GeneXpert, also with negative clinical manifestations and urine culture. In this study, the accuracy of diagnosis based on detection of the CXCL10 gene in urine for diagnosis of active pulmonary TB was 2.8%. Future research is needed to improve the methods, among them are bigger size of urine samples and clearer medical history of patients. 

Esthesioneuroblastoma (ENB): A case report

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 15546-15546
Author(s):  
E. Troncoso ◽  
S. Bonicatto ◽  
A. Mainella ◽  
A. Barbero ◽  
M. Lavezzaro ◽  
...  
Keyword(s):  
Case Report ◽  
Maxillary Sinus ◽  
Soft Palate ◽  
Sensory System ◽  
Clinical Manifestations ◽  
Response To Therapy ◽  
Nasal Fossa ◽  
History Of ◽  
Left Maxillary Sinus ◽  
The Right

15546 Background: ENB is a rare embrionary tumor derived from neuroblasts of the olfactory sensory system. Polypoid mass with epistaxis or nasal obstruction are the most common clinical manifestations of this tumor. It’s invasive and it frequently causes regional and distant metastasis. ENB requires a multimodality therapy. The objective of this study is to describe the form of presentation, diagnosis, treatment and evolution of this tumor on a female patient (pt), as a casuistic contribution. Methods and Case Report: A 61 year old woman with a four month history of epistaxis, nasal pain and anosmia. CT shows nasal mass invading the entire nasal cavity and upper maxillary. Pt underwent nasal resection and reconstruction with frontal flaps. Anatomopathology: ENB invading the bone. Cromogranin (+), sinaptofisin (+), CK (−), NSE (−). Three months later: lesion on the right wing nasal and a mass in the soft palate. MRI: mass on the floor of the nasal fossa that involve the left maxillary sinus and the bone palate. Kadish stage C. We treated her with three cycles of chemotherapy using cisplatin 30 mg/sqM d 1–3 iv and etoposide 100 mg/sqM d 1–3 iv. After that, remission was observed in the wing nasal lesion but the the soft palate mass shows progression. MRI: mass in nasal fossa that destroys the left maxillary sinus and causes lysis of the upper maxillary and orbital floor. Pt was treated with radiotherapy (6000 cGy) showing complete remission of the nasal lession and partial response on the soft palate, verified by physical examination and RMI. Four months after the end of radiotherapy, she continues under control and maintains the response to therapy without evidence of progression. Conclusion: ENB is an unfrequent tumor without any standard treatment. In our case, the combination of surgery, CH and RT has been effective for local control of the disease with good tolerance and acceptable quality of life. No significant financial relationships to disclose.

Unilateral Multiple Extramedullary Plasmacytoma of the Choroid and Conjunctiva: A Case Report

2019 ◽  
Vol 4 (2) ◽  
pp. 152-156
Author(s):  
Shymaa Mohamed ◽  
Truman Silvasi ◽  
Anthony Kubat ◽  
Thomas Aaberg
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Radiation Dose ◽  
Poor Prognosis ◽  
Clinical Manifestations ◽  
Excisional Biopsy ◽  
Extramedullary Plasmacytoma ◽  
Eye Pain ◽  
History Of ◽  
Conjunctival Nodule

Purpose: We report a case of multiple extramedullary plasmacytoma (EMP) of the choroid and conjunctiva as a sign of multiple myeloma (MM) relapse. Methods: An observational case report with clinicopathologic correlation is presented. Results: A 45-year-old man with a 2.5-year history of MM presented with left eye pain. Examination revealed a conjunctival nodule and choroidal infiltrate in the left eye. Excisional biopsy demonstrated plasmacytoma of the conjunctiva and choroid. Despite radiotherapy and chemotherapy, multiple EMP recurred and the patient died 8 months after initial presentation. Conclusions: Multiple EMP of the choroid and conjunctiva has a poor prognosis and can present as a sign of MM relapse. Our imaging demonstrates the clinical manifestations of this tumor and can aid future diagnoses. Our radiation dose (20 Gy) was inadequate, which is an important reportable factor for future patients.

scholarly journals Dieulafoy’s lesion of the rectum: a case report and review of the literature

2017 ◽  
Vol 05 (09) ◽  
pp. E939-E942 ◽  
Author(s):  
Mo Wang ◽  
Xiang Bu ◽  
Jing Zhang ◽  
Shanshan Zhu ◽  
Ying Zheng ◽  
...  
Keyword(s):  
Case Report ◽  
Clinical Practice ◽  
Gastrointestinal Bleeding ◽  
Gastrointestinal Disease ◽  
Relevant Literature ◽  
Clinical Manifestations ◽  
Review Of The Literature ◽  
Dieulafoy’S Lesion ◽  
Surgical Interventions ◽  
History Of

AbstractOne patient with Dieulafoy’s lesion (DL) of the rectum who had a history of anal receptive intercourse is described and the relevant literature reviewed. DL is rare in clinical practice and is extremely rare in the rectum. It often affects patients with no history of cirrhosis or gastrointestinal disease and occurs with abrupt or recurrent gastrointestinal bleeding. Visible vessels can usually be found by endoscopy and coinstantaneous treatments are essential while surgical interventions can occur when necessary. The diagnosis of DL is mainly based on clinical manifestations and endoscopic features, and endoscopic treatment is the first option for hemostasis.

scholarly journals A case report of open appendectomy in treating acute perforated appendicitis with necrotizing fasciitis of the abdominal wall: a rare complication of a common disease*

2021 ◽  
Author(s):  
Rezvan Hosseinzadeh ◽  
Mohsen Rakhsha ◽  
Kataneh kazemi ◽  
Morteza behnamfar
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Rare Complication ◽  
Open Appendectomy ◽  
Perforated Appendicitis ◽  
Common Disease ◽  
Mild Abdominal Pain ◽  
History Of ◽  
Radiographic Data ◽  
Significant Weakness

We present a case of a 37-year-old woman referred to our hospital with a 1-week history of significant weakness, anorexia, and mild abdominal pain. According to laboratory and radiographic data, the patient was diagnosed with perforated appendicitis and gangrene.

scholarly journals Prolonged Fever and Exaggerated Hypercoagulopathy in Malaria Vivax Relapse and COVID-19 Co-infection: A Case Report

2021 ◽  
Author(s):  
Tri Pudy Asmarawati ◽  
Okla Sekar Martani ◽  
Bramantono Bramantono ◽  
Muhammad Vitanata Arifianto
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Malaria Infection ◽  
Treatment Guidelines ◽  
Clinical Manifestations ◽  
Malaria Prevalence ◽  
Nasopharyngeal Swab ◽  
Delayed Treatment ◽  
History Of ◽  
Endemic Areas

Abstract BackgroundCoronavirus disease 2019 (COVID-19) often causes atypical clinical manifestations similar to other infectious diseases. In malaria-endemic areas, the pandemic situation will very likely result in co-infection of COVID-19 and Malaria, although reports to date are still few. Meanwhile, in areas with low malaria prevalence, this disease will be challenging to diagnose because the symptoms closely resemble COVID-19.Case presentationA 23-year-old male patient presented to hospital with fever, anosmia, headache, and nausea since one week before. He was diagnosed with COVID-19 and treated for approximately ten days then discharged to continue self-quarantine at home. Two weeks later, he came back to the hospital with fever that was raised intermittently every two days, and was marked by a chilling-fever-sweating cycle. We conducted a laboratory test for malaria and nasopharyngeal swab for SARS CoV-2 PCR which confirmed both of the diagnosis. The laboratory examination showed markedly elevated D-dimer. He was treated with Dihydroartemisinin-Piperaquine (DHP) 4 tablets per day for three days and Primaquine 2 tablets per day for 14 days according to Indonesian national anti-malarial treatment guidelines. After six days of treatment, the patient had no complaints, and the results of laboratory tests had improved. This report describes the key points in considering the differential diagnosis and prompt treatment of malaria infection during the pandemic of COVID-19 in an endemic country to prevent the worse clinical outcomes. COVID-19 and malaria may also cause hypercoagulable state, so a co-infection of those diseases may impact on the prognosis of the disease.ConclusionThis case report shows that considering the possibility of a co-infection in COVID-19 patient who presents with fever can prevent delayed treatment that can worsen the disease outcome. Paying more attention to a history of travel to malaria-endemic areas, a history of previous malaria infection, and exploring anamnesis regarding the fever patterns in patients are important points in making a differential diagnosis of malaria infection during the COVID-19 pandemic.

Alkaptonuria – Many questions answered, further challenges beckon

2019 ◽  
Vol 57 (2) ◽  
pp. 106-120
Author(s):  
AS Davison ◽  
AT Hughes ◽  
AM Milan ◽  
N Sireau ◽  
JA Gallagher ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Human Subjects ◽  
Clinical Manifestations ◽  
Homogentisic Acid ◽  
Common Disease ◽  
Clinical Complications ◽  
Disease Modifying Therapy ◽  
Treatment Measures ◽  
History Of ◽  
Collagenous Tissues

Alkaptonuria is an iconic rare inherited inborn error of metabolism affecting the tyrosine metabolic pathway, resulting in the accumulation of homogentisic acid in the circulation, and significant excretion in urine. Dating as far back as 1500 BC in the Egyptian mummy Harwa, homogentisic acid was shown to be central to the pathophysiology of alkaptonuria through its deposition in collagenous tissues in a process termed ochronosis. Clinical manifestations occurring as a consequence of this are typically observed from the third decade of life, are lifelong and significantly affect the quality of life. In large supportive and palliative treatment measures are available to patients, including analgesia, physiotherapy and joint replacement. Studying the natural history of alkaptonuria, in a murine model and human subjects, has provided key insights into the biochemical and molecular mechanisms underlying the pathophysiology associated with the disease, and has enabled a better understanding of the common disease osteoarthritis. In the last decade, a major focus has been on an unlicensed disease-modifying therapy called nitisinone. This has been shown to be highly efficacious in reducing homogentisic acid, and it is hoped this will halt ochronosis, thus limiting the clinical complications associated with the disease. A well-documented metabolic consequence of nitisinone therapy is hypertyrosinaemia, the clinical implications of which are uncertain. Recent metabolomic studies have helped understand the wider metabolic consequences of nitisinone therapy.

scholarly journals Tattoos and human papilloma virus: A case report of tattoo-associated flat warts (verrucae planae)

2019 ◽  
Vol 7 ◽  
pp. 2050313X1985741
Author(s):  
Mark G Kirchhof ◽  
Se Mang Wong
Keyword(s):  
Case Report ◽  
Human Papilloma Virus ◽  
Clinical Manifestations ◽  
Human Papilloma Virus Infection ◽  
Virus Infections ◽  
Papilloma Virus ◽  
Long Latency ◽  
History Of ◽  
The Right ◽  
Flat Warts

The prevalence of tattoos is increasing and as such every physician must be aware of the potential adverse events associated with tattooing. Here we present a 36-year-old man with a recent history of skin-coloured papules appearing suddenly in a 20-year-old tattoo on the right forearm. Biopsy and histologic examination confirmed a diagnosis of verrucae planae or flat warts. Tattoo-associated human papilloma virus infections develop clinical manifestations after long latency periods and are often difficult to treat. The risk of tattoo-related human papilloma virus infection should be discussed when considering acquiring a tattoo.

scholarly journals Ectopic ganglion in cauda equina: case report

2016 ◽  
Vol 24 (6) ◽  
pp. 937-940
Author(s):  
Andrew K. Conner ◽  
Kar-Ming Fung ◽  
Jo Elle G. Peterson ◽  
Chad A. Glenn ◽  
Michael D. Martin
Keyword(s):  
Urinary Incontinence ◽  
Case Report ◽  
Spinal Dysraphism ◽  
Cauda Equina ◽  
Pathological Finding ◽  
Clinical Findings ◽  
Leg Pain ◽  
Open Biopsy ◽  
History Of ◽  
Space Occupying Lesion

Macroscopic ectopic or heterotopic ganglionic tissue within the cauda equina is a very rare pathological finding and is usually associated with spinal dysraphism. However, it may mimic genuine neoplasms of the cauda equina. The authors describe a 29-year-old woman with a history of back pain, right leg pain, and urinary incontinence in whom imaging demonstrated an enhancing mass located in the cauda equina at the L1–2 interspace. The patient subsequently underwent biopsy and was found to have a focus of ectopic ganglionic tissue that was 1.3 cm in greatest dimension. To the authors' knowledge, ectopic or heterotopic ganglionic tissue within the cauda equina in a patient without evidence of spinal dysraphism has never been reported. This patient presented with imaging and clinical findings suggestive of a neoplasm, and an open biopsy proved the lesion to be ectopic ganglionic tissue. The authors suggest that ectopic ganglionic tissue be added to the list of differential diagnoses of a space-occupying lesion arising from the cauda equina.

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