scholarly journals Study of the destructive activity of microorganisms isolated from soil contaminated by pesticides

2019 ◽  
Vol 122 ◽  
pp. 05007
Author(s):  
Azhar Malik ◽  
Gulzhamal Abdieva ◽  
Perizat Ualieva ◽  
Nuraly Akimbekov
Keyword(s):  
Plant Protection ◽  
Plant Protection Products ◽  
Term Treatment ◽  
Chemical Pollution ◽  
Toxic Substances ◽  
Long Term Treatment ◽  
Living Organisms ◽  
High Level ◽  
Organic Pesticides

Chemical pollution of natural and agricultural habitats is a growing global problem and a serious threat to the sustainability and health of people. Among various chemical ecotoxicants of anthropogenic origin, organochlorine pesticides are among the most stable and dangerous for the environment and humans. Pesticides are chemical plant protection products, the intensive and not always justified the use of which has led to the fact that recently they are also considered among the most dangerous pollutants. One of the serious environmental problems is the pollution of natural objects with organic pesticides with high toxicity and persistence. Toxic substances can enter the environment and pose a threat to all living organisms, including the microbial population of the soil. Microorganisms isolated from ecosystems exposed to long-term treatment with pesticides can quickly decompose these compounds. The problem related to the decomposition of pesticide residues in the soil is an important environmental issue. Microorganisms are able to most effectively decompose xenobiotic substances foreign to the biosphere. The ability of microorganisms to decompose pesticides is associated with biochemical reactions and a high level of their adaptation. In this study, the microbial diversity of the soil in the territories adjacent to the pesticide burial sites was studied.

scholarly journals The effect of long-term treatment with steroid hormones or tamoxifen on oestrogen receptors (alpha and beta) in the endometrium of ovariectomized cynomolgus macaques

2002 ◽  
Vol 175 (3) ◽  
pp. 673-681 ◽  
Author(s):  
H Wang ◽  
E Isaksson ◽  
B Von Schoultz ◽  
JM Cline ◽  
L Sahlin
Keyword(s):  
Hormone Treatment ◽  
Term Treatment ◽  
Response To Treatment ◽  
Oestrogen Receptors ◽  
Minor Variation ◽  
Protein Levels ◽  
Long Term Treatment ◽  
High Level ◽  
Er Alpha

The effects of oestrogen are mediated by two specific intracellular receptors, oestrogen receptors (ER) alpha and beta, which function as ligand-activated transcriptional regulators. Ovariectomized macaques (Macaca fascicularis) were used to study the regulation of ERalpha and ERbeta in the endometrium by immunohistochemistry and in situ hybridization after long-term hormone treatment. Animals were treated continuously for 35 Months with either conjugated equine oestrogen (CEE), medroxyprogesterone acetate (MPA), combined CEE/MPA, or tamoxifen (TAM). Treatment with CEE/MPA down-regulated ERalpha in the superficial glands. In the superficial stroma the ERalpha level was lower in the CEE/MPA group than in the CEE and MPA groups. ERbeta immunostaining was faint with minor variation in response to treatment, but increased in the superficial stroma after MPA treatment. The ratio of ERbeta/ERalpha increased in superficial stroma and gland after CEE/MPA treatment, and also in stroma after MPA and TAM. Cystic endometrial hyperplasia was observed in TAM-treated animals, in combination with a high level of ERalpha protein expression. The present data show that long-term hormone treatment affects the ERalpha and ERbeta protein levels in the endometrium. The balance between ERalpha and ERbeta seems to be important for the proliferative response to oestrogen.

EVIDENCE FOR PLASMIN-MEDIATED FIBRINOLYSIS AFTER /RELEASE OF TISSUE PLASMINOGEN ACTIVATOR BY DESMOPRESSIN INFUSION

1987 ◽  
Author(s):  
G D O Lowe ◽  
J T Douglas ◽  
M Small ◽  
C Kluft ◽  
C D Forbes
Keyword(s):  
Plasminogen Activator ◽  
Venous Blood ◽  
Term Treatment ◽  
Fibrin Plate ◽  
Long Term Treatment ◽  
Post Infusion ◽  
Control Of Diabetes ◽  
High Level

A relationship between tPA activity and plasmin-mediated fibrinolysis in vivo (plasma levels of Bβ15-42-containing peptides) has been suggested by our previous studies: inverse correlations of Bβ15-42 levels with obesity and triglyceride levels (both associated with high tPA inhibition) in an epidemiological study; and increased levels of Bβ15-42 following improved control of diabetes, or treatment with oral or intramuscular stanozolol (which decrease tPA inhibition). The aim of the present study was to establish whether or not intravenous infusion of desamino-D-arginine vasopressin (DDAVP, desmopressin) is followed by increases in plasmin-mediated fibrinolysis in vivo (plasma Bβ15-42 levels). Desmopressin (0.3 μg/kg body weight) was infused intravenously over 15 mins in 22 subjects. Venous blood was obtained by separate venepuncture before and 15 mins after the end of the infusion, for assay of plasminogen activator activity of the euglobulin fraction on fibrin plates, tPA activity, and Bβ15-42 levels (RIA,IMCO). 18 subjects showed normal increases in fibrin plate lysis and in tPA activity after desmopressin (median tPA activity 120 mU/ml pre-, 5000 mU/ml post-infusion, p<0.001). In these 18 subjects, Bβ15-42 levels rose significantly (median 1.5pmol/ml pre-, 4.2 pmol/ml post-infusion, p<0.001). Four subjects showed no significant increases in fibrin plate lysis or in tPA activity after desmopressin (non-responders): all had significantly elevated levels of tPA-inhibition. In these 4 subjects no increases in Bβ15-42 levels were observed. In one nonresponder, who suffered a large myocardial infarction due to angiographic thrombosis with no atheroma at the age of 22 years, long-term treatment with stanozolol normalised the high level of tPA-inhibition, as well as the fibrin plate lysis and tPA activity responses to desmopressin: Bβ15-42 level then showed a normal response after desmopressin infusion (2.2 to 5 pmol/ml). We conclude that desmopressin infusion increases plasmin-mediated fibrinolysis in vivo, but only in the presence of normal increases in tPA activity.

Long-Term Treatment Effects of Sensory Motor Retuning in a Pianist with Focal Dystonia

2011 ◽  
Vol 26 (2) ◽  
pp. 106-107 ◽  
Author(s):  
Jaume Rosset-Llobet ◽  
Sílvia Fàbregas-Molas
Keyword(s):  
Behavioral Treatment ◽  
Term Treatment ◽  
Illness Onset ◽  
Focal Hand Dystonia ◽  
Long Term Treatment ◽  
Sensory Motor ◽  
High Level ◽  
Hand Dystonia ◽  
Piano Playing

Here we present the case of a pianist suffering from unilateral focal hand dystonia for 10 yrs which affected his piano playing as well as other activities of daily life. The treatment applied was sensory motor retuning (SMR), a behavioral treatment for focal hand dystonia. Improvement was clearly achieved from the beginning of therapy. After 10 mos of treatment, performance levels were comparable to those before illness onset. The patient returned to high-level piano playing, and after 8 yrs of follow-up, performance remains normal.

IL-3 and ribavirin induce high level expression of megakaryocytic markers and messages during long-term treatment of a megakaryocytic leukemia cell line

1994 ◽  
Vol 160 (1) ◽  
pp. 29-39 ◽  
Author(s):  
Alokes Majumdar ◽  
Stephen Kerby ◽  
Brian Mullikin ◽  
Michael M. Seidman ◽  
Paula E. Stenberg ◽  
...  
Keyword(s):  
Cell Line ◽  
Leukemia Cell ◽  
Term Treatment ◽  
Leukemia Cell Line ◽  
High Level Expression ◽  
Long Term Treatment ◽  
High Level

Complete Suppression of the Symptoms of Congenital Erythropoietic Porphyria by Long-Term Treatment with High-Level Transfusions

1986 ◽  
Vol 314 (16) ◽  
pp. 1029-1031 ◽  
Author(s):  
Sergio Piomelli ◽  
Maureen B. Poh-Fitzpatrick ◽  
Carol Seaman ◽  
Lawrence M. Skolnick ◽  
Walter E. Berdon
Keyword(s):  
Term Treatment ◽  
Complete Suppression ◽  
Long Term Treatment ◽  
Congenital Erythropoietic Porphyria ◽  
High Level

scholarly journals A report from XIX Schizophrenia Forum Conference in Warsaw

2016 ◽  
Vol 17 (2) ◽  
pp. 118-123
Author(s):  
Ewelina Dziwota ◽  
Kamila Dziwota ◽  
Marcin Olajossy
Keyword(s):  
Psychotic Disorders ◽  
Treatment Guidelines ◽  
Term Treatment ◽  
Scientific Conference ◽  
Long Term Treatment ◽  
History Of ◽  
Clinical Thinking ◽  
High Level ◽  
Conference Centre

AbstractOn 10-11th March in Warsaw, in the Conference Center Muranow, there was held a scientific conference “Schizophrenia-Forum”, organized for the nineteenth time. In this edition, particular attention was paid to educational aspects, by virtue of the fact that among the participants of the Conference there was a large number of young physicians specializing in psychiatry.The formula of the two-day Conference based on the experts’ debates in a particular way affected the participants, so the conference was very interesting, it enabled the exchange of experiences and reflections on the problems of schizophrenia. The conference was attended by leading scientists and clinicians, for example: Marek Jarema, Janusz Rybakowski, Andrzej Czernikiewicz, Jerzy Samochowiec, Dominika Dudek and others, which is why it allowed to enrich the knowledge of the diagnosis and treatment of psychotic disorders and good presentation of mature clinical thinking. The organizer of the Conference was the Foundation III Department of Psychiatry, “Syntonia” and the guest of honor was Dr. Peter Falkai - Head of the Department of Psychiatry and Psychotherapy Ludwig Maximilian University in Munich. The lecture by Professor Falkaia entitled Schizophrenia treatment guidelines, at a plenary lecture, was presented in English, translated simultaneously, and was divided into parts: the characteristics of schizophrenia, guidelines for pharmacotherapy of schizophrenia, pharmacotherapy of schizophrenia - states of acute pharmacotherapy of schizophrenia - long-term treatment, side effects of long-term pharmacotherapy and conclusions. After a two-day Conference the hugely popular workshop sessions took place. They were addressed to physicians during specialization. All workshop sessions were very popular, as well as the entire conference, which became a forum for the exchange of information, ideas and experiences, sometimes intriguing, inspiring and innovative but never blank. At the end of the Conference the certificates were distributed and there was the opportunity for guests - visiting the permanent exhibition “1000 years of history of Polish Jews,” Polin, located at the Conference Centre Muranow. XIX Conference on Schizophrenia Forum 2016 was an interesting event cognitively and it maintained a high level of scientific and substantive jurisdiction important events in Polish psychiatry.

"Is Intensity Decisive?" Changes in Levels of Self-efficacy, Stages of Change and Physical Activity for Two Different Forms of Prescribed Exercise

2011 ◽  
Vol 20 (3-4) ◽  
pp. 85-112
Author(s):  
Thomas Bredahl ◽  
John Singhammer ◽  
Kirsten Roessler
Keyword(s):  
Physical Activity ◽  
Treatment Group ◽  
Stages Of Change ◽  
Self Efficacy ◽  
Best Practice ◽  
Term Treatment ◽  
Activity Level ◽  
Long Term Treatment ◽  
High Level

"Is Intensity Decisive?" Changes in Levels of Self-efficacy, Stages of Change and Physical Activity for Two Different Forms of Prescribed Exercise This study explores the long-term treatment effect on levels of self efficacy, stages of change and physical activity of prescribed exercise (EoP) for two different groups: a treatment group (TG) which includes patients with hypertension and a prevention group (PG). This study is an evaluation of best practice. Analyses were conducted at baseline and after 4, 10 and 16 months. The TG received group-based training and motivational counseling. The PG received motivational counseling only. No significant change in self-efficacy across time and no differences between groups were found. A significantly greater probability of reporting high level of stages of change was observed for the TG. No differences were observed between the groups across time. A significant increase in physical activity level across time was found, but no differences between the groups were found. EoP improves participants' level of physical activity and stages of change, regardless of the intensity of the intervention.

Hypnotherapy is effective in the long-term treatment of functional dyspepsia

2001 ◽  
Vol 120 (5) ◽  
pp. A115-A115 ◽  
Author(s):  
E CALVERT ◽  
L HOUGHTON ◽  
P COOPER ◽  
P WHORWELL
Keyword(s):  
Functional Dyspepsia ◽  
Term Treatment ◽  
Long Term Treatment
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