GaInN/GaN heterostructures grown in production scale MOVPE reactors

The removal of slag from melt surface of hot metal and steel ladles is a necessary condition to provide a deep desulphurization and dephosphorization of hot metal and steel in the process of their processing. A review of methods of slag skimming presented, mainly based on slag mechanical shoveling and its removal out of ladles by vacuum sucking. It was shown, that manipulators design for the slag skimming working instrument moving depends on the production scale, mass of the processed heats, amount and properties of the slag to be removed, production process intensity and ecological requirements. Peculiarities of designs and technical parameters of machines for slag skimming presented, designed by Irkutsk plant of heavy machinery, Scientific and Production Enterprise n.a. M.I. Platov, VNIIMETMASH, Kuznetsk and Novolipetsk steel plants. Technological methods of control of slag composition and physical properties considered, first of all of viscosity and fluidity, which have significant effect on selection of a method of slag skimming. Advantages and drawbacks of actions, aimed at more complete slag removal from metal surface by a scraper noted including bath blowing off by an inert gas, liquid slag tapping into am intermediate settling tank following its removal into a slag bowl. In case of satisfactory fluidity it is possible to slag removal by vacuum sucking, which at the same time promoted the melt degassing. Work done in this area abroad noted. Methods of vacuum slag removal developed in the USA and Japan described.

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Upscaling of foam forming technology for pilot scale

TAPPI Journal ◽

10.32964/tj18.8.461 ◽

2019 ◽

Vol 18 (8) ◽

Cited By ~ 1

Author(s):

JANI LEHMONEN ◽

TIMO RANTANEN ◽

KARITA KINNUNEN-RAUDASKOSKI

Keyword(s):

Production Efficiency ◽

Strength Loss ◽

Pilot Scale ◽

Foam Density ◽

Forming Process ◽

Production Scale ◽

Forming Technology ◽

Wet Pressing ◽

Foam Forming ◽

Board Industry

The need for production cost savings and changes in the global paper and board industry during recent years have been constants. Changes in the global paper and board industry during past years have increased the need for more cost-efficient processes and production technologies. It is known that in paper and board production, foam typically leads to problems in the process rather than improvements in production efficiency. Foam forming technology, where foam is used as a carrier phase and a flowing medium, exploits the properties of dispersive foam. In this study, the possibility of applying foam forming technology to paper applications was investigated using a pilot scale paper forming environment modified for foam forming from conventional water forming. According to the results, the shape of jet-to-wire ratios was the same in both forming methods, but in the case of foam forming, the achieved scale of jet-to-wire ratio and MD/CD-ratio were wider and not behaving sensitively to shear changes in the forming section as a water forming process would. This kind of behavior would be beneficial when upscaling foam technology to the production scale. The dryness results after the forming section indicated the improvement in dewatering, especially when foam density was at the lowest level (i.e., air content was at the highest level). In addition, the dryness results after the pressing section indicated a faster increase in the dryness level as a function of foam density, with all density levels compared to the corresponding water formed sheets. According to the study, the bonding level of water- and foam-laid structures were at the same level when the highest wet pressing value was applied. The results of the study show that the strength loss often associated with foam forming can be compensated for successfully through wet pressing.

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The Analysis of Potential of Straw Mushroom Development by Using Empty Fruit Bunches Material in Lampung Province

Journal of Engineering and Scientific Research ◽

10.23960/jesr.v1i2.16 ◽

2019 ◽

Vol 1 (2) ◽

Author(s):

Sarono Sarono

Keyword(s):

Palm Oil ◽

Efficiency Ratio ◽

Crude Palm Oil ◽

Production Scale ◽

Empty Fruit Bunches ◽

Straw Mushroom

The empty fruit bunches (EFB) are by-product of crude palm oil (CPO) production, and it is not widely used optimally. One of products produced from EFB with development potentials is straw mushroom. The objective of this research was to analyze the potentials of EFB material and straw mushroom based on EFB material in Lampung province. The result showed that the EFB potential in Lampung province was 111,144 ton annually and straw mushroom was 4,835 ton annually. The biology efficiency ratio of EFB into straw mushroom in production scale was averagely 3.93%. Districts having potentials for developing straw mushroom business by using EFB material were Mesuji, Middle Lampung, Tulang Bawang, Way Kanan, and North Lampung.

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AM-Serienproduktion für die Automobilindustrie/AM series production for the automotive industry

wt Werkstattstechnik online ◽

10.37544/1436-4980-2020-11-12-16 ◽

2020 ◽

Vol 110 (11-12) ◽

pp. 752-757

Author(s):

Lukas Weiser ◽

Marco Batschkowski ◽

Niclas Eschner ◽

Benjamin Häfner ◽

Ingo Neubauer ◽

...

Keyword(s):

Additive Manufacturing ◽

Automotive Industry ◽

Series Production ◽

Production Scale ◽

Additive Fertigung ◽

Small Series ◽

Start Up ◽

3D Printed ◽

Component Quality

Die additive Fertigung schafft neue Gestaltungsfreiheiten. Im Rahmen des Prototypenbaus und der Kleinserienproduktion kann das Verfahren des selektiven Laserschmelzens genutzt werden. Die Verwendung in der Serienproduktion ist bisher aufgrund unzureichender Bauteilqualität, langen Anlaufzeiten sowie mangelnder Automatisierung nicht im wirtschaftlichen Rahmen möglich. Das Projekt „ReAddi“ möchte eine erste prototypische Serienfertigung entwickeln, mit der additiv gefertigte Bauteile für die Automobilindustrie wirtschaftlich produziert werden können. Additive manufacturing (AM) offers new freedom of design. The selective laser-powderbed fusion (L-PBF) process can be used for prototyping and small series production. So far, it has not been economical to use it on a production scale due to insufficient component quality, long start-up times and a lack of automation. The project ReAddi aims to develop a first prototype series production to cost-effectively manufacture 3D-printed components for the automotive industry.

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Models to inform neutralizing antibody therapy strategies during pandemics: the case of SARS-CoV-2

Antibody Therapeutics ◽

10.1093/abt/tbab006 ◽

2021 ◽

Vol 4 (1) ◽

pp. 60-71

Author(s):

Donovan Guttieres ◽

Anthony J Sinskey ◽

Stacy L Springs

Keyword(s):

Value Chain ◽

Neutralizing Antibodies ◽

Resource Constraints ◽

Antibody Therapy ◽

Neutralizing Antibody ◽

Epidemiological Data ◽

Production Costs ◽

Production Scale ◽

Design And Optimization ◽

Critical Components

Abstract Background Neutralizing antibodies (nAbs) against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) can play an important role in reducing impacts of the COVID-19 pandemic, complementing ongoing public health efforts such as diagnostics and vaccination. Rapidly designing, manufacturing and distributing nAbs requires significant planning across the product value chain and an understanding of the opportunities, challenges and risks throughout. Methods A systems framework comprised of four critical components is presented to aid in developing effective end-to-end nAbs strategies in the context of a pandemic: (1) product design and optimization, (2) epidemiology, (3) demand and (4) supply. Quantitative models are used to estimate product demand using available epidemiological data, simulate biomanufacturing operations from typical bioprocess parameters and calculate antibody production costs to meet clinical needs under various realistic scenarios. Results In a US-based case study during the 9-month period from March 15 to December 15, 2020, the projected number of SARS-CoV-2 infections was 15.73 million. The estimated product volume needed to meet therapeutic demand for the maximum number of clinically eligible patients ranged between 6.3 and 31.5 tons for 0.5 and 2.5 g dose sizes, respectively. The relative production scale and cost needed to meet demand are calculated for different centralized and distributed manufacturing scenarios. Conclusions Meeting demand for anti-SARS-CoV-2 nAbs requires significant manufacturing capacity and planning for appropriate administration in clinical settings. MIT Center for Biomedical Innovation’s data-driven tools presented can help inform time-critical decisions by providing insight into important operational and policy considerations for making nAbs broadly accessible, while considering time and resource constraints.

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Green Hydrogen Catapult targets 50-fold global production scale-up in next six years

Fuel Cells Bulletin ◽

10.1016/s1464-2859(20)30549-6 ◽

2020 ◽

Vol 2020 (12) ◽

pp. 1

Keyword(s):

Scale Up ◽

Production Scale

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Impact of Solidification on Inclusion Morphology in ESR and PESR Remelted Martensitic Stainless Steel Ingots

Metals ◽

10.3390/met11030408 ◽

2021 ◽

Vol 11 (3) ◽

pp. 408

Author(s):

Ewa Sjöqvist Persson ◽

Sofia Brorson ◽

Alec Mitchell ◽

Pär G. Jönsson

Keyword(s):

Stainless Steel ◽

Martensitic Stainless Steel ◽

Dendritic Structure ◽

Steel Grade ◽

Solidification Structure ◽

Production Scale ◽

Steel Grades ◽

Steel Ingots ◽

Columnar Dendritic Structure ◽

The Impact

This study focuses on the impact of solidification on the inclusion morphologies in different sizes of production-scale electro-slag remelting (ESR) and electro-slag remelting under a protected pressure-controlled atmosphere, (PESR), ingots, in a common martensitic stainless steel grade. The investigation has been carried out to increase the knowledge of the solidification and change in inclusion morphologies during ESR and PESR remelting. In order to optimize process routes for different steel grades, it is important to define the advantages of different processes. A comparison is made between an electrode, ESR, and PESR ingots with different production-scale ingot sizes, from 400 mm square to 1050 mm in diameter. The electrode and two of the smallest ingots are from the same electrode charge. The samples are taken from both the electrode, ingots, and rolled/forged material. The solidification structure, dendrite arm spacing, chemical analyzes, and inclusion number on ingots and/or forged/rolled material are studied. The results show that the larger the ingot and the further towards the center of the ingot, the larger inclusions are found. As long as an ingot solidifies with a columnar dendritic structure (DS), the increase in inclusion number and size with ingot diameter is approximately linear. However, at the ingot size (1050 mm in diameter in this study) when the center of the ingot converts to solidification in the equiaxial mode (EQ), the increase in number and size of the inclusions is much higher. The transition between a dendritic and an equiaxial solidification in the center of the ingots in this steel grade takes place in the region between the ingot diameters of 800 and 1050 mm.

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Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand

Vaccines ◽

10.3390/vaccines9010003 ◽

2020 ◽

Vol 9 (1) ◽

pp. 3

Author(s):

Zoltán Kis ◽

Cleo Kontoravdi ◽

Robin Shattock ◽

Nilay Shah

Keyword(s):

Production Process ◽

Messenger Rna ◽

Vaccination Campaign ◽

Vaccine Dose ◽

Economic Feasibility ◽

Small Scale ◽

Production Scale ◽

Working Volume ◽

Global Demand ◽

The Impact

To overcome pandemics, such as COVID-19, vaccines are urgently needed at very high volumes. Here we assess the techno-economic feasibility of producing RNA vaccines for the demand associated with a global vaccination campaign. Production process performance is assessed for three messenger RNA (mRNA) and one self-amplifying RNA (saRNA) vaccines, all currently under clinical development, as well as for a hypothetical next-generation saRNA vaccine. The impact of key process design and operation uncertainties on the performance of the production process was assessed. The RNA vaccine drug substance (DS) production rates, volumes and costs are mostly impacted by the RNA amount per vaccine dose and to a lesser extent by the scale and titre in the production process. The resources, production scale and speed required to meet global demand vary substantially in function of the RNA amount per dose. For lower dose saRNA vaccines, global demand can be met using a production process at a scale of below 10 L bioreactor working volume. Consequently, these small-scale processes require a low amount of resources to set up and operate. RNA DS production can be faster than fill-to-finish into multidose vials; hence the latter may constitute a bottleneck.

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